RETRATO SIN IDENTIFICAR [Material gráfico]

Copia digital. Madrid : Ministerio de Educación, Cultura y Deporte, 201

Ginsenoside Rb1 Prevents H2O2-Induced HUVEC Senescence by Stimulating Sirtuin-1 Pathway

We have previously reported that Ginsenoside Rb1 may effectively prevent HUVECs from senescence, however, the detailed mechanism has not demonstrated up to now. Recent studies have shown that sirtuin-1 (Sirt1) plays an important role in the development of endothelial senescence. The purpose of this study was to explore whether Sirt1 is involved in the action of Ginsenoside Rb1 regarding protection against H2O2-induced HUVEC Senescence.Senescence induced by hydrogen peroxide (H2O2) in human umbilical vein endothelial cells (HUVECs) was examined by analyzing plasminogen activator inhibitor-1 (PAI-1) expression, cell morphology, and senescence-associated beta-galactosidase (SA-β-gal) activity. The results revealed that 42% of control-treated HUVECs were SA-β-gal positive after treatment by 60 µmol/L H2O2, however, this particular effect of H2O2 was decreased more than 2-fold (19%) in the HUVECs when pretreated with Rb1 (20 µmol/L) for 30 min. Additionally, Rb1 decreased eNOS acetylation, as well as promoted more NO production that was accompanied by an increase in Sirt1 expression. Furthermore, upon knocking down Sirt1, the effect of Rb1 on HUVEC senescence was blunted.The present study indicated that Ginsenoside Rb1 acts through stimulating Sirt1 in order to protect against endothelial senescence and dysfunction. As such, Sirt1 appears to be of particular importance in maintaining endothelial functions and delaying vascular aging

Social Integration and Residence Intention of Foreigners in Western China: Evidence from Xi’an

Since “Belt and Road Initiative” (BRI) of 2014, the number of foreigners in China has increased rapidly and China has become an importing country for immigrants, a change ongoing since the beginning of the 21st century. To respond to the rapidly increasing number of foreigners in China, the government frequently revised the immigration policies and issued new regulations for foreigners. However, scholars understand very little about how the foreigners perceive their integration into Chinese society or decide to pursue long-term residency or lawful permanent resident status. While some pioneering studies touch on this, with samples from the coastal megacities, no empirical evidence has been collected from smaller, inner cities. Three new findings about the foreigners in Xi’an, a major city in western China, fill this literature gap. First, the level of subjective social integration is largely influenced by the local networks. Second, the level of objective social integration depends largely on local and hometown networks. Third, the intention to obtain long-term and permanent residency in China is more evident in those foreigners who come from countries covered by the BRI and who consider China to be a better place to live than their home country