Chen, Lin

Cheng, Cailian

Liu, Dinghui

Qian, Xiaoxian

Song, Zhiming

Zheng, Zhenda

Elsevier - Publisher Connector 

GW26-e1259 Significance of Soluble Urokinase-type Plasminogen Activator Receptor in Patients with Coronary Heart Disease 

C144 J O U R N A L O F T H E A M E R I C A N C O L L E G E O F C A R D I O L O G Y , V O L . 6 6 , N O . 1 6 , S U P P L S , 2 0 1 5CONCLUSIONS 1. The most common type of SCF is simultaneous
three-vessel involvement; The most common vascular involvement is
LAD.
2. The speed of coronary ﬂow slows down with the increasing of the
diameter of coronary.
3. The increasing of PCV, D-D, BUN, the diameter of left main and
the proximal RCA may be risk factors of SCF.
GW26-e1259
Signiﬁcance of Soluble Urokinase-type Plasminogen Activator Receptor in
Patients with Coronary Heart Disease
Zhenda Zheng, Cailian Cheng, Dinghui Liu, Zhiming Song, Lin Chen,
Xiaoxian Qian
The Third Afﬁliated Hospital, SUN Yat-sen University, Guangzhou
510630, China
OBJECTIVES To uncover the clinical roles of Soluble Urokinase-type
Plasminogen Activator Receptor (su-PAR) in different types of coro-
nary heart disease.
METHODS We divided all the cases into four groups: 30 cases in NCAD
group, 20 cases in SA group, 25 cases in UA group, 30 cases in AMI
group. In all these groups, the plasma levels of su-PAR in plasma were
measured with a solid phase enzyme-linked immuneosorbent assay
(ELISA) when the cases were brought into this study and two weeks
after they were brought into this study.
RESULTS All the samples taken from the peripheral vessels were
immediately analyzed after the cases were brought into this study in
the 4 groups, the difference of the plasma levels of su-PAR was sig-
niﬁcant. The AMI group were higher than the UA group [(4.530.57)
mg/L vs. (3.230.48) mg/L, P<0.001]; the UA group were higher than
the SA group [(3.230.48) mg/L vs. (1.450.27) mg/L, P<0.001];
however the different between the SA group and the NCAD group was
not signiﬁcant [(1.450.27) mg/L vs. (1.400.25) mg/L, P>0.05]; the
difference of the plasma levels of su-PAR between the cases were
brought into this study and two weeks after was not signiﬁcant
(0.0050.05,P>0.05).
CONCLUSIONS The change of su-PAR are different in different types
of coronary heart disease patients. There is an ascending trend of
su-PAR in the SA group, the ascending trend is more signiﬁcant in the
UA group, and the most signiﬁcant in the AMI group.GW26-e2273
Cardiac Troponin I and Longitudinal Strain Predict for Prediction of Clinical
Outcomes in Patients with ST-segment Elevation
Zhongling Mo, Yin Wang, Liping Chen
Department of Echocardiography, Cardiovascular Disease Center, 1st
Hospital of Jilin University
OBJECTIVES Cardiac biomarkers including the levels of cardiac
troponin I (cTnI) after ST-segment elevation myocardial infarction
(STEMI) is associated with infarct size and left ventricular remodeling
and dysfunction. But the relationship between the biochemical mea-
sures and the global cardiac function is less well deﬁned. This study is
aim to observe the level of cTnI and longitudinal strain by speckling
tracking in prediction of the outcomes.
METHODS 115 patients admitted with acute ST-elevation myocardial
infarction (STEMI) in left descending artery and received percuta-
neous coronary intervention (PCI) in our study. Forty age-matched
persons without prior MI, arrhythmia, hypertension, valvular disease
and DM with normal coronary artery detected by coronary angiog-
raphy were control group. The level of cTnI was studied from venous
blood samples within 1 hour, 6 hours 12 hours and 18 hours. Within
72 hours of the onset of STEMI and 3 months follow-up, two-dimen-
sional echocardiography was performed within 72 hours, 3 months
follow-up.
RESULTS Biochemical markers showed a peak at 6 hours
(159.74122.0) for cTnI. Multivariable analysis revealed that the peak
systolic longitudinal strain was independently related to structural
changes which showed the 15% increase in diastolic dimension at
3-month follow-up compared with baseline.CONCLUSIONS Our study showed cardiac troponin I and reduced
systolic longitudinal strain were related to the outcomes of STEMI.
cTnI levels are a useful risk stratiﬁcation tool in STEMI patient.GW26-e5428
A performance comparison of ﬁve different DECT image sets for Detecting
Myocardial Perfusion Defects compared with 13NH3 PET
Wenhuan Li, Kuncheng Li
Xuanwu Hospital of Capital Medical University
OBJECTIVES To identify the optimal dual energy computed tomog-
raphy (DECT) image set for the detection of myocardial perfusion
defects, by comparing diagnostic performance of ﬁve different DECT
image sets (iodine mapping, monoenergetic images, nonlinearly
blended images, linearly blended images, and 100 KV images), using
13NH3 positron emission tomography (PET) as reference standard.
METHODS Forty-nine consecutive patients, with known or strongly
suspected of coronary artery disease, were prospectively enrolled in
our study. Cardiac DECT was performed at rest state using a second-
generation 128-slice dual-source CT. The DECT data were recon-
structed to iodine mapping, monoenergetic images, nonlinearly
blended images, linearly blended images, and 100KV images by
different postprocessing techniques. The myocardial perfusion de-
fects on DECT images were visually assessed by two observers, using
standard 17-segment model. Diagnostic accuracy of ﬁve different im-
age sets was assessed using 13NH3 PET as the gold standard.
Discrimination was quantiﬁed using the area under the receiver
operating characteristic (ROC) curve (AUC), and AUCs were compared
using the method of DeLong.
RESULTS The DECT and PET examinations were successfully
completed in 30 patients and a total of 510 segments were analyzed.
Cardiac PET revealed myocardial perfusion defects in 209 segments
(41%). In ROC curve analysis, iodine mapping showed signiﬁcantly
better performance (AUC, 0.922) than monoenergetic images (AUC,
0.813), 100 kV images (AUC, 0.779), nonlinearly blended images (AUC,
0.763), and linearly blended images (AUC, 0.728) (P <.001 for each
comparison).
CONCLUSIONS DECT iodine mapping correlates well with 13NH3 PET
and is superior to other DECT image sets for the detection of
myocardial perfusion defects in the ﬁrst-pass myocardial perfusion.GW26-e4456
The clinical and the angiographic characteristics of the Korean-Chinese
nationality and Han nationality with coronary heart disease of Yanbian area
in China
Lan Cui, Chunzi Jin
Yan Bian University Hospital
OBJECTIVES To compare the clinical and the angiographic charac-
teristics of the Korean-Chinese and Han nationality with coronary
heart disease (CHD) in Yanbian area in China.
METHODS The risk factors and distribution of culprit vessels of
coronary artery were retrospectively analyzed in 753 cases of
CHD. The levels of plasma nitric oxide (NO) and the protein of endo-
thelial nitric oxide synthase (eNOS) were measured by Elisa kit
(Cusabio).
RESULTS Alcohol consumption was signiﬁcantly higher in Korean-
Chinese than in Han patients. No difference was observed in other risk
factors between two groups. The numbers of stenotic coronary ar-
teries were signiﬁcantly higher in Korean-Chinese patients. Plasma
NO and eNOS were signiﬁcantly lower in Korean - Chinese patients.
CONCLUSIONS There are signiﬁcant differences in the angiographic
characteristics and the levels of plasma NO and eNOS between
Korean-Chinese and Han patients with CHD in Yanbian area in China.
Reduced eNOS may be responsible for increased stenotic coronary
arteries in Korean-Chinese CHD patients compared to Han in Yanbian
area in China. Mechanistic link between alcohol consumption and
eNOS/NO deﬁciency or angiographic abnormality needs further
investigation.


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GW26-e1259 Significance of Soluble Urokinase-type Plasminogen Activator Receptor in Patients with Coronary Heart Disease

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