Chinese Experience with Global G3 Standard-Setting

China’s growth strategy as set out in the 11th 5-year plan in 2005 called for upgrading of product quality, the development of an innovation society, and reduced reliance on foreign intellectual property with high license fees. Consistent with this policy, China has been involved in recent years with the development of a Chinese standard in third generation (3G) mobile phone technology, both in negotiating the standard and seeing it through to commercialization. This is the first case of a developing country both originating and successfully negotiating a telecommunications standard and this experience raises issues for China’s future development strategy based on product and process upgrading in manufacturing. We argue that while precedent setting from an international negotiating point of view, the experience has thus far is unproven commercially. But the lessons learned will benefit future related efforts in follow-on technologies if similar Chinese efforts are made.This paper documents Chinese standard-setting efforts from proposal submission to ITU to the current large-scale trial network deployment in China and overseas trial networks deployment. We discuss the underlying objectives for this initiative, evaluate its effectiveness, and assess its broader implications for Chinese development policy.

Imaging and variability studies of CTA~102 during the 2016 January γ\gamma-ray flare

The $\gamma$-ray bright blazar CTA 102 is studied using imaging (new 15 GHz and archival 43 GHz Very Long Baseline Array, VLBA data) and time variable optical flux density, polarization degree and electric vector position angle (EVPA) spanning between 2015 June 1 and 2016 October 1, covering a prominent $\gamma$-ray flare during 2016 January. The pc-scale jet indicates expansion with oscillatory features upto 17 mas. Component proper motions are in the range 0.04 - 0.33 mas/yr with acceleration upto 1.2 mas followed by a slowing down beyond 1.5 mas. A jet bulk Lorentz factor $\geq$ 17.5, position angle of 128.3 degrees, inclination angle $\leq$ 6.6 degrees and intrinsic half opening angle $\leq$ 1.8 degrees are derived from the VLBA data. These inferences are employed in a helical jet model to infer long term variability in flux density, polarization degree, EVPA and a rotation of the Stokes Q and U parameters. A core distance of $r_{\rm core,43 \ GHz}$ = 22.9 pc, and a magnetic field strength at 1 pc and the core location of 1.57 G and 0.07 G respectively are inferred using the core shift method. The study is useful in the context of estimating jet parameters and in offering clues to distinguish mechanisms responsible for variability over different timescales.Comment: 20 pages, 7 figures, 3 tables; accepted for publication in Ap

Chinese experience with global G3 standard-setting

China's growth strategy as set out in the 11th 5-year plan in 2005 called for upgrading of product quality, the development of an innovation society, and reduced reliance on foreign intellectual property with high license fees. Consistent with this policy, China has been involved in recent years with the development of a Chinese standard in third generation (3G) mobile phone technology, both in negotiating the standard and seeing it through to commercialization. This is the first case of a developing country both originating and successfully negotiating a telecommunications standard and this experience raises issues for China's future development strategy based on product and process upgrading in manufacturing. We argue that while precedent setting from an international negotiating point of view, the experience has thus far is unproven commercially. But the lessons learned will benefit future related efforts in follow-on technologies if similar Chinese efforts are made. This paper documents Chinese standard-setting efforts from proposal submission to ITU to the current large-scale trial network deployment in China and overseas trial networks deployment. We discuss the underlying objectives for this initiative, evaluate its effectiveness, and assess its broader implications for Chinese development policy.

Education in inpatient children and young people’s mental health services

<p>As a chronic disease, osteoarthritis (OA) leads to the degradation of both cartilage and subchondral bone, its development being mediated by proinflammatory cytokines like interleukin-1β. In the present study, the anti-inflammatory effect of specnuezhenide (SPN) in OA and its underlying mechanism were studied in vitro and in vivo. The results showed that SPN decreases the expression of cartilage matrix-degrading enzymes and the activation of NF-κB and wnt/β-catenin signaling, and increases chondrocyte-specific gene expression in IL-1β-induced inflammation in chondrocytes. Furthermore, SPN treatment prevents the degeneration of both cartilage and subchondral bone in a rat model of OA. To the best of our knowledge, this study is the first to report that SPN decreases interleukin-1β-induced inflammation in rat chondrocytes by inhibiting the activation of the NF-κB and wnt/β-catenin pathways, and, thus, has therapeutic potential in the treatment of OA.</p

Source-Frequency Phase-Referencing Observation of AGNs with KaVA Using Simultaneous Dual-Frequency Receiving

The KVN(Korean VLBI Network)-style simultaneous multi-frequency receiving mode is demonstrated to be promising for mm-VLBI observations. Recently, other Very long baseline interferometry (VLBI) facilities all over the globe start to implement compatible optics systems. Simultaneous dual/multi-frequency VLBI observations at mm wavelengths with international baselines are thus possible. In this paper, we present the results from the first successful simultaneous 22/43 GHz dual-frequency observation with KaVA(KVN and VERA array), including images and astrometric results. Our analysis shows that the newly implemented simultaneous receiving system has brought a significant extension of the coherence time of the 43 GHz visibility phases along the international baselines. The astrometric results obtained with KaVA are consistent with those obtained with the independent analysis of the KVN data. Our results thus confirm the good performance of the simultaneous receiving systems for the non-KVN stations. Future simultaneous observations with more global stations bring even higher sensitivity and micro-arcsecond level astrometric measurements of the targets.Comment: 8 pages, 6 figures, Published in JKA

Tailoring the Direct Current Modulation Response of Electrically Pumped Semiconductor Nano-Laser Arrays

Semiconductor nano-lasers have been a topic of interest from the perspective of advancing the capabilities of photonic integration. Nano-lasers are perceived as the means to achieve improved functionality in photonic integrated circuits. The properties and performance of nano-lasers have been examined by means of simulations and laboratory measurements. Nano-lasers lend themselves to integration to form dense arrays in both one and two dimensions. In a recent work, a theoretical treatment was presented for the dynamic behaviour of stand-alone electrically pumped nano-laser arrays. In this work, the response of nano-laser arrays to direct current modulation is examined. As in previous works, attention is given to two prototype array geometries: a linear three-element linear array and an equilateral triangular array. Large one-dimensional arrays can be built by repeating this elementary linear array. Two-dimensional photonic integrated circuits can incorporate the triangular arrays studied here. Such prototypical configurations offer opportunities to tailor the modulation response of the nano-laser arrays. The principal factors which provide that capability are the coupling strengths between lasers in the arrays and the direct modulation parameters. The former are fixed at the design and manufacture stage of the array whilst the latter can be chosen. In addition, the enhancement of the spontaneous emission rate via the so-called Purcell effect in nano-lasers offers a device-specific means for accessing a range of modulation responses. Two-dimensional portraits of the regimes of differing modulation responses offer a convenient means for determining the dynamics that may be accessed by varying the laser drive current. It is shown by these means that a rich variety of modulation responses can be accessed in both linear and triangular arrays

Pleckstrin Homology (PH) Domain Leucine-Rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C

The proper establishment of epithelial polarity allows cells to sense and respond to signals that arise from the microenvironment in a spatiotemporally controlled manner. Atypical PKCs (aPKCs) are implicated as key regulators of epithelial polarity. However, the molecular mechanism underlying the negative regulation of aPKCs remains largely unknown. In this study, we demonstrated that PH domain leucine-rich repeat protein phosphatase (PHLPP), a novel family of Ser/Thr protein phosphatases, plays an important role in regulating epithelial polarity by controlling the phosphorylation of both aPKC isoforms. Altered expression of PHLPP1 or PHLPP2 disrupted polarization of Caco2 cells grown in 3D cell cultures as indicated by the formation of aberrant multi-lumen structures. Overexpression of PHLPP resulted in a decrease in aPKC phosphorylation at both the activation loop and the turn motif sites; conversely, knockdown of PHLPP increased aPKC phosphorylation. Moreover, in vitro dephosphorylation experiments revealed that both aPKC isoforms were substrates of PHLPP. Interestingly, knockdown of PKCζ, but not PKCι, led to similar disruption of the polarized lumen structure, suggesting that PKCζ likely controls the polarization process of Caco2 cells. Furthermore, knockdown of PHLPP altered the apical membrane localization of aPKCs and reduced the formation of aPKC-Par3 complex. Taken together, our results identify a novel role of PHLPP in regulating aPKC and cell polarity