A Common Genetic Variant (97906C>A) of DAB2IP/AIP1 Is Associated with an Increased Risk and Early Onset of Lung Cancer in Chinese Males

DOC-2/DAB2 interactive protein (DAB2IP) is a novel identified tumor suppressor gene that inhibits cell growth and facilitates cell apoptosis. One genetic variant in DAB2IP gene was reported to be associated with an increased risk of aggressive prostate cancer recently. Since DAB2IP involves in the development of lung cancer and low expression of DAB2IP are observed in lung cancer, we hypothesized that the variations in DAB2IP gene can increase the genetic susceptibility to lung cancer. In a case-control study of 1056 lung cancer cases and 1056 sex and age frequency-matched cancer-free controls, we investigated the association between two common polymorphisms in DAB2IP gene (−1420T>G, rs7042542; 97906C>A, rs1571801) and the risk of lung cancer. We found that compared with the 97906CC genotypes, carriers of variant genotypes (97906AC+AA) had a significant increased risk of lung cancer (adjusted odds ratio [OR] = 1.33, 95%CI = 1.04–1.70, P = 0.023) and the number of variant (risk) allele worked in a dose-response manner (Ptrend = 0.0158). Further stratification analysis showed that the risk association was more pronounced in subjects aged less than 60 years old, males, non-smokers, non-drinkers, overweight groups and in those with family cancer history in first or second-degree relatives, and the 97906A interacted with overweight on lung cancer risk. We further found the number of risk alleles (97906A allele) were negatively correlated with early diagnosis age of lung cancer in male patients (P = 0.003). However, no significant association was observed on the −1420T>G polymorphism. Our data suggested that the 97906A variant genotypes are associated with the increased risk and early onset of lung cancer, particularly in males

From concept to action: a united, holistic and One Health approach to respond to the climate change crisis

It is unequivocal that human influence has warmed the planet, which is seriously affecting the planetary health including human health. Adapting climate change should not only be a slogan, but requires a united, holistic action and a paradigm shift from crisis response to an ambitious and integrated approach immediately. Recognizing the urgent needs to tackle the risk connection between climate change and One Health, the four key messages and recommendations that with the intent to guide further research and to promote international cooperation to achieve a more climate-resilient world are provided

Stabilizing a Rotary Inverted Pendulum Based on Logarithmic Lyapunov Function

The stabilization of a Rotary Inverted Pendulum based on Lyapunov stability theorem is investigated in this paper. The key of designing control laws by Lyapunov control method is the construction of Lyapunov function. A logarithmic function is constructed as the Lyapunov function and is compared with the usual quadratic function theoretically. The comparative results show that the constructed logarithmic function has higher numerical accuracy and faster convergence speed than the usual quadratic function. On this basis, the control law of stabilizing Rotary Inverted Pendulum is designed based on the constructed logarithmic function by Lyapunov control method. The effectiveness of the designed control law is verified by experiments and is compared with LQR controller and the control law designed based on the quadratic function. Moreover, the system robustness is analyzed when the system parameters contain uncertainties under the designed control law

Analytic solution of field distribution and demagnetization function of ideal hollow cylindrical field source

The Halbach type hollow cylindrical permanent magnet array (HCPMA) is a volume compact and energy conserved field source, which have attracted intense interests in many practical applications. Here, using the complex variable integration method based on the Biot-Savart Law (including current distributions inside the body and on the surfaces of magnet), we derive analytical field solutions to an ideal multipole HCPMA in entire space including the interior of magnet. The analytic field expression inside the array material is used to construct an analytic demagnetization function, with which we can explain the origin of demagnetization phenomena in HCPMA by taking into account an ideal magnetic hysteresis loop with finite coercivity. These analytical field expressions and demagnetization functions provide deeper insight into the nature of such permanent magnet array systems and offer guidance in designing optimized array system

Creation of periodic subwavelength ripples on tungsten surface by ultra-short laser pulses

Formation <span class="hitHilite">of</span> <span class="hitHilite">periodic</span> <span class="hitHilite">subwavelength</span> <span class="hitHilite">ripples</span> <span class="hitHilite">on</span> a metallic <span class="hitHilite">tungsten</span> <span class="hitHilite">surface</span> is investigated through a line-scribing method under the irradiation <span class="hitHilite">of</span> 800 nm, 50 fs to 8 ps <span class="hitHilite">ultra</span>-<span class="hitHilite">short</span> <span class="hitHilite">laser</span> <span class="hitHilite">pulses</span>. The distinctive features <span class="hitHilite">of</span> the induced ripple structures are described in detail with different <span class="hitHilite">laser</span> parameters. Experimental measurements reveal that with gradual decrease <span class="hitHilite">of</span> the <span class="hitHilite">laser</span> fluence, the pulse duration or the scanning speed, the ripple period is inclined to reduce but the ripple depth tends to become pronounced. Theoretical analyses suggest that the transient dielectric function change <span class="hitHilite">of</span> the <span class="hitHilite">tungsten</span> <span class="hitHilite">surface</span> mainly originates from the nonequilibrium distribution <span class="hitHilite">of</span> electrons due to the d-band transitions. A sandwich-like physical model <span class="hitHilite">of</span> air-plasma-target is proposed and the excitation <span class="hitHilite">of</span> a <span class="hitHilite">surface</span> plasmon polaritonic (SPP) wave is supposed to occur <span class="hitHilite">on</span> the interface between the metallic target and the electron plasma layer. Formation <span class="hitHilite">of</span> <span class="hitHilite">ripples</span> can be eventually attributed to the <span class="hitHilite">laser</span>-SPP interference. Theoretical interpretations are consistent with the experimental observations

Rapid Discrimination and Prediction of Ginsengs from Three Origins Based on UHPLC-Q-TOF-MS Combined with SVM

Ginseng, which contains abundant ginsenosides, grows mainly in the Jilin, Liaoning, and Heilongjiang in China. It has been reported that the quality and traits of ginsengs from different origins were greatly different. To date, the accurate prediction of the origins of ginseng samples is still a challenge. Here, we integrated ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) with a support vector machine (SVM) for rapid discrimination and prediction of ginseng from the three main regions where it is cultivated in China. Firstly, we develop a stable and reliable UHPLC-Q-TOF-MS method to obtain robust information for 31 batches of ginseng samples after reasonable optimization. Subsequently, a rapid pre-processing method was established for the rapid screening and identification of 69 characteristic ginsenosides in 31 batches ginseng samples from three different origins. The SVM model successfully distinguished ginseng origin, and the accuracy of SVM model was improved from 83% to 100% by optimizing the normalization method. Six crucial quality markers for different origins of ginseng were screened using a permutation importance algorithm in the SVM model. In addition, in order to validate the method, eight batches of test samples were used to predict the regions of cultivation of ginseng using the SVM model based on the six selected quality markers. As a result, the proposed strategy was suitable for the discrimination and prediction of the origin of ginseng samples

Data_Sheet_3_Understanding the China-Tanzania Malaria Control Project: lessons learned from a multi-stakeholder qualitative study.PDF

BackgroundTanzania is among the countries with the highest malaria cases and deaths worldwide, where vulnerable populations have been severely affected due to poverty and weakness in health system and infrastructure. The China-Tanzania Malaria Control Project (the Project) was a two-phase global health intervention project implemented between 2015 and 2021 that aimed to transfer project-designated intervention experience in malaria elimination to the Tanzanian health system. This study aims to identify the barriers and facilitators encountered during the Project and to improve our understanding of the emerging phenomenon of South-South global health collaboration.MethodsWe conducted thematic analysis of qualitative data collected from a purposive sample of 14 participants from multiple stakeholders including project management office, project implementation agency, funding partners and external evaluators of the Project. A conceptual framework was developed to construct the interviews guides. The interviews were transcribed verbatim, crossover checked, translated into English, and analyzed with NVivo 12.0. We conducted the open coding followed by the axial coding based on the Grounded Theory to generate themes and subthemes, and identified key influencing factors that aided or hindered the malaria control in Tanzania.ResultsThe findings suggested that malaria control strategies should largely be tailored due to varied socioeconomic contexts. The perceived enablers in practice include project-designated intervention experiences and technologies, professional and self-learning capabilities of the implementation team, sustainable financial assistance, and support from the international partners. The barriers include the shortage of global health talents, existing gaps to meet international standards, defects in internal communication mechanisms, inadequacy of intergovernmental dialogue, and limitations in logistical arrangements. A checklist and policy implications for China's future engagement in malaria control in resource-limited settings have been proposed.ConclusionsThe initiative of Health Silk Road has generated strong global interest in promoting development assistance in health. In the hope of generalizing the evidence-based interventions to high malaria-endemic countries in Africa, the need for China to carefully face the challenges of funding gaps and the lack of support from recipient governments remains ongoing. It is recommended that China should form an institutionalized scheme and sustainable funding pool to ensure the steady progress of development assistance in health.</p