A Trust Model Based on Service Classification in Mobile Services

Internet of Things (IoT) and B3G/4G communication are promoting the pervasive mobile services with its advanced features. However, security problems are also baffled the development. This paper proposes a trust model to protect the user's security. The billing or trust operator works as an agent to provide a trust authentication for all the service providers. The services are classified by sensitive value calculation. With the value, the user's trustiness for corresponding service can be obtained. For decision, three trust regions are divided, which is referred to three ranks: high, medium and low. The trust region tells the customer, with his calculated trust value, which rank he has got and which authentication methods should be used for access. Authentication history and penalty are also involved with reasons.Comment: IEEE/ACM Internet of Things Symposium (IOTS), in conjunction with GreenCom 2010, IEEE, Hangzhou, China, December 18-20, 201

Gene Transfer of Calcitonin Gene-Related Peptide Inhibits Macrophages and Inflammatory Mediators in Vein Graft Disease

Vein graft disease is a chronic inflammatory disease and limits the late results of coronary revascularization. Calcitonin gene-related peptide (CGRP) inhibits macrophages infiltrated and inflammatory mediators, we hypothesized that transfected CGRP gene inhibits macrophages infiltrated and inflammatory mediators in vein graft disease. Autologous rabbit jugular vein grafts were incubated ex vivo in a solution of mosaic adeno-associated virus vectors containing CGRP gene (AAV2/1.CGRP) 、escherichia coli lac Z gene (AAV2/1.LacZ) or saline and then interposed in the carotid artery. Intima/media ratio were evaluated at postoperative 4 weeks, Macrophages were marked with CD68 antibody by immunocytochemistry. Inflammatory mediators were mensurated with real-time PCR. Neointimal thickening was significantly suppressed in AAV2/1.CGRP group. Macrophages infiltrated and inflammatory mediators monocyte chemoattractant protein-1 (MCP-1)、tumor necrosis factorα(TNF-α)、inducible nitricoxide synthase (iNOS)、matrix metalloproteinase-9 (MMP-9) was significantly suppressed in AAV2/1.CGRP group.Gene transfected AAV2/1.CGRP suppressed neointimal hyperplasia in vein graft disease by suppressed macrophages infiltrated and inflammatory mediators

2,6-Bis(4-methoxy­phen­yl)-4-phenyl­pyridine

In the title compound, C25H21NO2, which was synthesized by the condensation of 2,6-bis­(4-methoxy­phen­yl)-4-phenyl­pyridinium tetra­fluoro­borate with ammonia under microwave irradiation and solvent-free conditions, the angles between the central pyridine ring and the three benzene rings are 22.3 (2), 35.3 (2) and 19.8 (2)°. In the crystal, inter­molecular C—H⋯π hydrogen-bond inter­actions link the mol­ecules

Exploring Bilingual Books with Five Chinese First Graders: Children’s Responses and Biliteracy Development

This qualitative case study examines how five Chinese first graders responded to bilingual English/Chinese picture books and how bilingual books used during an eight-week study session impacted their bilingual and biliteracy development. Reader response and socio-cultural theories were the theoretical perspectives that underpin this study. Four bilingual picture books were selected for the five participating Chinese children to read during an eight-week period. The researchers specifically sought answers to two questions: (1) How do Chinese children respond to the bilingual books? (2) What impact do the bilingual book study sessions have on children’s bilingual and biliteracy development? The findings suggested these children responded positively by becoming engaged, making connections, activating cultural and background knowledge, and showing unnoticed talent. In addition, bilingual books, combined with appropriate instruction, can be a powerful resource to promote bilingual and biliteracy development

Differential effects of dosing regimen on the safety and efficacy of dasatinib: retrospective exposure-response analysis of a Phase III study.

PurposeDasatinib is a prototypic short half-life BCR-ABL1 tyrosine kinase inhibitor. The recommended dose of dasatinib for chronic myeloid leukemia in chronic phase was changed from 70 mg twice daily to 100 mg once daily following a Phase III dose-optimization study. To better understand the superior benefit-risk profile of dasatinib 100 mg once daily, exposure-response was characterized for efficacy (major cytogenetic response) and safety (pleural effusion).Patients and methodsDasatinib exposure in patients with chronic myeloid leukemia in chronic phase was determined by population pharmacokinetic analysis of data from seven dasatinib clinical studies (N = 981), including the Phase III dose-optimization study (n = 567). Data from the Phase III study were then used to characterize exposure-response relationships for the four dasatinib treatment regimens investigated (100 mg once daily, 50 mg twice daily, 140 mg once daily, and 70 mg twice daily).ResultsMajor cytogenetic response was significantly (P < 0.01) associated with weighted average steady-state dasatinib plasma concentrations, and pleural effusion was significantly associated with trough concentration. Major cytogenetic response was also significantly associated with maintenance of uninterrupted dosing. The 100 mg once daily arm had the lowest steady-state trough concentration of the four dose arms investigated in the Phase III study, and although this arm also had the lowest weighted average steady-state dasatinib plasma concentration, it had the highest dose maintenance.ConclusionDasatinib dose optimization to 100 mg once daily from 70 mg twice daily significantly minimizes adverse events while maintaining efficacy by exploiting differences in the measures of exposure associated with efficacy and safety

Investigating NCE Preservice Candidates and Graduates’ Visual Literacy Practices in Middle and High School Science and Social Studies Classrooms

The study investigates whether secondary education science and social studies candidates transferred what they learned about visual literacy in their teacher preparation program to their practicum/student teaching classrooms. The study included qualitative and quantitative methods to document the candidates’ visual literacy knowledge and practices. The findings indicate that the candidates did employ visual literacy strategies as visuals had already been regularly used in their classrooms. But, they had limited success in implementing the strategies learned in their methods courses. In addition, they showed a good working knowledge of what visual literacy is and acknowledged its value in the classroom. They also stated that the use of visuals and visual literacy would be integral parts of their teaching in the future