Mechanism Analysis and Simulation of Coplanar Multi-Electrode Capacitive Ice Thickness Measuring Sensor

In this paper, we use the coplanar multi-electrode for designing a rod-shaped sensor for measuring the ice thickness. In order to analyze and study mechanism and feasibility of ice thickness measurements using this technique, we use modes of mathematical model derivation and software simulation to study coplanar multi-electrode capacitance sensors. It uses MAXWELL software to simulate the coplanar multi-electrode capacitance sensor under the models which are being approached by three different media, namely ice, air and water. Both mathematical model derivation and simulation results show that the sensor designed with coplanar multi-electrode capacitance can be used to level the automated measurement of sea ice or river ice thickness. The accuracy is ± 1 cm

The Role of CD1d and MR1 Restricted T Cells in the Liver

The liver is one of the most important immunological organs that remains tolerogenic in homeostasis yet promotes rapid responses to pathogens in the presence of a systemic infection. The composition of leucocytes in the liver is highly distinct from that of the blood and other lymphoid organs, particularly with respect to enrichment of innate T cells, i.e., invariant NKT cells (iNKT cells) and Mucosal-Associated Invariant T cells (MAIT cells). In recent years, studies have revealed insights into their biology and potential roles in maintaining the immune-environment in the liver. As the primary liver-resident immune cells, they are emerging as significant players in the human immune system and are associated with an increasing number of clinical diseases. As such, innate T cells are promising targets for modifying host defense and inflammation of various liver diseases, including viral, autoimmune, and those of tumor origin. In this review, we emphasize and discuss some of the recent discoveries and advances in the biology of innate T cells, their recruitment and diversity in the liver, and their role in various liver diseases, postulating on their potential application in immunotherapy

Solution to the problem of the threshold segmentation of tomographic data

Описано решение проблемы пороговой сегментации томографических данных. Получение уровня сегментации одного среза данных позволяет проводить бинаризацию остальных срезов данных

Analysis of Characteristic Quality Indexes of Gaoyou Duck Eggs

To explore the quality characteristics of Gaoyou duck eggs, metabolomics was used to analyze the quality indexes, basic nutritional indexes and small molecule metabolites. The results showed that the mass, egg shape index, egg yolk color, Haugh unit, egg white height, egg yolk index and crude protein content of Gaoyou duck eggs were higher than those of the other studied breeds. The contents of total amino acids, umami amino acids, branched-chain amino acids, total fatty acids and unsaturated fatty acids were higher, and the content of saturated fatty acids was lower, indicating that sensory quality parameters, amino acids and fatty acids can characterize the quality of Gaoyou duck eggs. The characteristic components of Gaoyou duck eggs were uncovered by metabolomic fingerprinting, principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and hierarchical cluster analysis (HCA). Totally 252 compounds and 22 differential compounds were identified in egg yolk, and 184 compounds and 40 differential compounds in egg white. Among them, uridine 5’-monophosphate, guanosine 5’-monophosphate, and N-acetyl-D-glucosamine were the main differential nutrients, and arachidonic acid in egg yolk was the unique nutrient of Gaoyou duck eggs, while indole was not detected in the egg white of Gaoyou duck eggs

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

ASH1L histone methyltransferase plays a crucial role in the pathogenesis of different diseases, including acute leukemia. While ASH1L represents an attractive drug target, developing ASH1L inhibitors is challenging, as the catalytic SET domain adapts an inactive conformation with autoinhibitory loop blocking the access to the active site. Here, by applying fragment-based screening followed by medicinal chemistry and a structure-based design, we developed first-in-class small molecule inhibitors of the ASH1L SET domain. The crystal structures of ASH1L-inhibitor complexes reveal compound binding to the autoinhibitory loop region in the SET domain. When tested in MLL leukemia models, our lead compound, AS-99, blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo. This work validates the ASH1L SET domain as a druggable target and provides a chemical probe to further study the biological functions of ASH1L as well as to develop therapeutic agents

High-Efficient Micro Reacting Pipe with 3D Internal Structure: Design, Flow Simulation, and Metal Additive Manufacturing

The micro reacting pipe with 3D internal structure, which is a micromixer with the shape of the pipe, has shown great advantages regarding mass transfer and heat transfer. Since the fluid flow is mostly laminar at the micro-scale, which is unfavorable to the diffusion of reactants, it is important to understand the influence of the geometry of the microchannel on the fluid flow for improving the diffusion of the reactants and mixing efficiency. On the other hand, it is a convenient method to manufacture a micro reacting pipe in one piece through metal additive manufacturing without many post-processing processes. In this paper, a basis for the design of a micromixer model was provided by combining the metal additive manufacturing process constraints with computational fluid dynamics (CFD) simulation. The effects of microchannel structures on fluid flow and mixing efficiency were studied by CFD simulation whose results showed that the internal micro-structure had a significantly positive effect on the mixing efficiency. Based on the simulation results, the splitting-collision mechanism was discussed, and several design rules were obtained. Two different materials were selected for manufacturing with the laser powder bed fusion (L-PBF) technology. After applying pressure tests to evaluate the quality of the formed parts and comparing the corrosion-resistance of the two materials, one material was picked out for the industrial application. Additionally, the chemical experiment was conducted to evaluate the accuracy of the simulation. The experimental results showed that the mixing efficiency of the micro reacting pipe increased by 56.6%, and the optimal determining size of the micro reacting pipe was 0.2 mm. The study can be widely used in the design and manufacture of a micromixer, which can improve efficiency and reacting stability in this field

Design and Application of a Standalone Hybrid Wind–Solar System for Automatic Observation Systems Used in the Polar Region

Continuous power supply for unmanned and automatic observation systems without suitable energy-storage capabilities in the polar regions is an urgent problem and challenge. However, few power-supply systems can stably operate over the long term in extreme environments, despite excellent performance under normal environments. In this study, a standalone hybrid wind⁻solar system is proposed, based on operation analysis of the observing system in the Arctic Ocean, the polar environments, and renewable-energy distribution in the polar regions. Energy-storage technology suitable for cold regions is introduced to support the standalone hybrid wind⁻solar system. Mathematical models of the power system at low temperature are also proposed. The low-temperature performance and characteristics of lead⁻acid battery are comprehensively elucidated, and a dedicated charging strategy is developed. A hybrid wind⁻solar charging circuit is developed using a solar charging circuit, a wind turbine charging circuit, a driver circuit, a detection circuit, an analog-to-digital converter (ADC) circuit, and an auxiliary circuit. The low temperature stability of charging circuit is test from −50 °C to 30 °C. Temperature correction algorithm is designed to improve the efficiency of the power supply system. The power generation energy of the power system was simulated based on the monthly average renewable energy data of Zhongshan Station. A case study was applied to examine the technical feasibility of the power system in Antarctica. The five-month application results indicate that the power system based on renewable energy can maintain stable performance and provide sufficient power for the observing system in low ambient temperatures. Therefore, this power system is an ideal solution to achieve an environmentally friendly and reliable energy supply in the polar regions

A Study of a Standalone Renewable Energy System of the Chinese Zhongshan Station in Antarctica

China has built four stations in Antarctica so far, and Zhongshan Station is the largest station among them. Continuous power supply for manned stations mainly relies on fuel. With the gradual increase in energy demand at the station and cost of fuel traffic from China to Zhongshan station in Antarctica, reducing fuel consumption and increasing green energy utilization are urgent problems. This research considers a standalone renewable energy system. The polar environments and renewable energy distribution of area of Zhongshan station are analyzed. The physical model, operation principle, and mathematical modeling of the proposed power system were designed. Low-temperature performance and state of charge (SOC) estimation method of the lead–acid battery were comprehensively tested and evaluated. A temperature control strategy was adopted to prevent the battery from low-temperature loss of the battery capacity. Energy management strategy of the power system was proposed by designing maximum power point tracking (MPPT) control strategies for wind turbine and PV array. The whole power system is broadly composed of a power generator (wind turbine and PV array), an uploading circuit, a three-phase rectifier bridge, an interleaved Buck circuit, a DC/DC conversion circuit, a switch circuit, a power supply circuit, an amplifier, a driver circuit, a voltage and current monitoring, a load, battery units and a control system. A case study in Antarctica was applied and can examine the technical feasibility of the proposed system. The results of the case study reveal that the scheme of standalone renewable energy system can satisfy the power demands of Zhongshan Station in normal operation