Causal effects of specific gut microbiota on musculoskeletal diseases: a bidirectional two-sample Mendelian randomization study

BackgroundRecent observational studies and clinical trials demonstrated an association between gut microbiota and musculoskeletal (MSK) diseases. Nonetheless, whether the gut microbiota composition has a causal effect on the risk of MSK diseases remains unclear.MethodsBased on large-scale genome-wide association studies (GWAS), we performed a two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between gut microbiota and six MSK diseases, namely osteoporosis (OP), fracture, sarcopenia, low back pain (LBP), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). Instrumental variables for 211 gut microbiota taxa were obtained from the largest available GWAS meta-analysis (n = 18,340) conducted by the MiBioGen consortium. And the summary-level data for six MSK diseases were derived from published GWAS. The inverse-variance weighted (IVW) method was conducted as a primary analysis to estimate the causal effect, and the robustness of the results was tested via sensitivity analyses using multiple methods. The Bonferroni-corrected test was used to determine the strength of the causal relationship between gut microbiota and various MSK diseases. Finally, a reverse MR analysis was applied to evaluate reverse causality.ResultsAccording to the IVW method, we found 57 suggestive causal relationships and 3 significant causal relationships between gut microbiota and MSK diseases. Among them, Genus Bifidobacterium (β: 0.035, 95% CI: 0.013–0.058, p = 0.0002) was associated with increased left handgrip strength, Genus Oxalobacter (OR: 1.151, 95% CI: 1.065–1.245, p = 0.0003) was correlated with an increased risk of LBP, and Family Oxalobacteraceae (OR: 0.792, 95% CI: 0.698–0.899, p = 0.0003) was linked with a decreased risk of RA. Subsequently, sensitivity analyses revealed no heterogeneity, directional pleiotropy, or outliers for the causal effect of specific gut microbiota on MSK diseases (p > 0.05). Reverse MR analysis showed fracture may result in a higher abundance of Family Bacteroidales (p = 0.030) and sarcopenia may lead to a higher abundance of Genus Sellimonas (p = 0.032).ConclusionGenetic evidence suggested a causal relationship between specific bacteria taxa and six MSK diseases, which highlights the association of the “gut-bone/muscle” axis. Further exploration of the potential microbiota-related mechanisms of bone and muscle metabolism might provide novel insights into the prevention and treatment of MSK diseases

Analysis of the influencing factors of vitality and built environment of shopping centers based on mobile-phone signaling data.

Nowadays, shopping centers not only provides commercial function but also serve as a public space. In this article, we take Nanshan district of Shenzhen as an example, based on the characteristics information of people activities provided by Mobile-phone Signaling Data, using the standard deviation ellipse method to classify the direction of people in shopping centers, and then applying the entropy weighting method to analyze the vitality factors of shopping centers from three perspectives: visitors' density, revisit rate, and the average length of stay. Finally, we analyzed the influence factors of the surrounding built environment based on correlation analysis to discuss the results with field survey data. The results show that (1) shopping centers in Nanshan District are classified into wide-area type and geo-regional type according to the gathering of visitors. The shopping centers with high comprehensive vitality are basically wide-area type. (2) The factors influencing the vitality of shopping centers are different between wide-area type and geo-regional type. The vitality of wide-area type is mainly influenced by the traffic accessibility and whether they are located in adjacent to large public spaces such as squares and green public; the vitality of geo-regional type shopping centers is mainly influenced by the number of people within a 15-minute walking circle, and the high-vitality of geo-regional shopping centers are generally located in densely populated areas

Vivaldi Antenna for Railway Cutting Monitoring

A planar Vivaldi antenna was reconstructed and assessed as a candidate for a short range, high range resolution railway cutting monitoring radar. The initial flare section of the Vivaldi antenna was found to control the return loss of this type of antenna at lower frequencies, and a compact antenna for 120% fractional bandwidth was demonstrated experimentally. Group delay was used as a UWB antenna assessment method, and the prototype antenna gave reasonable performance across the lower half of the band considered

Preferences in Farmland Eco-Compensation Methods: A Case Study of Wuhan, China

Successful farmland eco-compensation projects need to reflect the heterogeneous preferences both from suppliers and beneficiaries. This paper tries to answer this question by investigating both citizen and farmer preferences for different farmland eco-compensation methods in Wuhan, China, and explore some of the socio-demographic characteristics that contribute to their preferences. Based on the data of 288 citizens and 331 farmers, the multinomial logit model was employed to analyze their preferences for the four farmland eco-compensation methods (monetary compensation, in-kind compensation, technology compensation and policy compensation), respectively. The results show that: (1) Monetary compensation is the most welcomed farmland eco-compensation method among both citizens and farmers. (2) Despite farmers and citizens both putting a high value on monetary compensation methods, citizens are more likely to provide compensation methods that can help farmers improve their living standards in a sustainable method (in-kind compensation, technology compensation and policy compensation). Farmers are less likely to choose the in-kind compensation method. (3) The preference for farmland eco-compensation systems of farmers and citizens are influenced by different socio-demographic characteristics. The results can help the government to design more aimed farmland eco-compensation methods for farmers with different socio-demographic characteristics

Preferences in Farmland Eco-Compensation Methods: A Case Study of Wuhan, China

Successful farmland eco-compensation projects need to reflect the heterogeneous preferences both from suppliers and beneficiaries. This paper tries to answer this question by investigating both citizen and farmer preferences for different farmland eco-compensation methods in Wuhan, China, and explore some of the socio-demographic characteristics that contribute to their preferences. Based on the data of 288 citizens and 331 farmers, the multinomial logit model was employed to analyze their preferences for the four farmland eco-compensation methods (monetary compensation, in-kind compensation, technology compensation and policy compensation), respectively. The results show that: (1) Monetary compensation is the most welcomed farmland eco-compensation method among both citizens and farmers. (2) Despite farmers and citizens both putting a high value on monetary compensation methods, citizens are more likely to provide compensation methods that can help farmers improve their living standards in a sustainable method (in-kind compensation, technology compensation and policy compensation). Farmers are less likely to choose the in-kind compensation method. (3) The preference for farmland eco-compensation systems of farmers and citizens are influenced by different socio-demographic characteristics. The results can help the government to design more aimed farmland eco-compensation methods for farmers with different socio-demographic characteristics

Current situation of building types around Mixc World.

Current situation of building types around Mixc World.</p