Rad54: the Swiss Army knife of homologous recombination?

Homologous recombination (HR) is a ubiquitous cellular pathway that mediates transfer of genetic information between homologous or near homologous (homeologous) DNA sequences. During meiosis it ensures proper chromosome segregation in the first division. Moreover, HR is critical for the tolerance and repair of DNA damage, as well as in the recovery of stalled and broken replication forks. Together these functions preserve genomic stability and assure high fidelity transmission of the genetic material in the mitotic and meiotic cell divisions. This review will focus on the Rad54 protein, a member of the Snf2-family of SF2 helicases, which translocates on dsDNA but does not display strand displacement activity typical for a helicase. A wealth of genetic, cytological, biochemical and structural data suggests that Rad54 is a core factor of HR, possibly acting at multiple stages during HR in concert with the central homologous pairing protein Rad51

Harmonics of Parton Saturation in Lepton-Jet Correlations at the EIC

Parton saturation is one of the most intriguing phenomena in the high energy nuclear physics research frontier, especially in the upcoming era of the Electron-Ion Collider (EIC). The lepton-jet correlation in deep inelastic scattering provides us with a new gateway to the parton saturation at the EIC. In particular, we demonstrate that azimuthal angle anisotropies of the lepton-jet correlation are sensitive to the strength of the saturation momentum in the EIC kinematic region. In contrast to the predictions based on the collinear framework calculation, significant nuclear modification of the anisotropies is observed when we compare the saturation physics results in e + p and e + Au scatterings. By measuring these harmonic coefficients at the EIC, one can conduct quantitative analysis in different collisional systems and unveil compelling evidence for saturation effects.Comment: 7 pages, 3 figure

Mitigating Pooling Bias in E-commerce Search via False Negative Estimation

Efficient and accurate product relevance assessment is critical for user experiences and business success. Training a proficient relevance assessment model requires high-quality query-product pairs, often obtained through negative sampling strategies. Unfortunately, current methods introduce pooling bias by mistakenly sampling false negatives, diminishing performance and business impact. To address this, we present Bias-mitigating Hard Negative Sampling (BHNS), a novel negative sampling strategy tailored to identify and adjust for false negatives, building upon our original False Negative Estimation algorithm. Our experiments in the Instacart search setting confirm BHNS as effective for practical e-commerce use. Furthermore, comparative analyses on public dataset showcase its domain-agnostic potential for diverse applications.Comment: Submitted to WWW'24 Industry Trac

Bis(μ-3-hydroxy­benzoato-κ3 O,O′:O)bis­[aqua­(3-hydroxy­benzoato-κ2 O,O′)(1,10-phenanthroline-κ2 N,N′)lead(II)] monohydrate

In the centrosymmetric binuclear title complex, [Pb2(C7H5O3)4(C12H8N2)2(H2O)2]·H2O, each Pb atom is eight-coordinated in a PbO6N2 environment by two N atoms from the 1,10-phenanthroline (phen) ligand, five carboxylate O atoms from four 3-hydroxy­benzoate anions and one O atom from the coordinated water mol­ecule in a distorted bicapped trigonal-prismatic geometry. The benzoate groups coordinate each PbII atom in two different ways. Two benzoate ions behave as bidentate ligands to the Pb atom, and another benzoate ion bridges the Pb atoms, forming a binuclear structure. The dimeric units are packed via O—H⋯O hydrogen bonds and π–π inter­actions between the aromatic rings of neighboring mol­ecules, with centroid–centroid distances of 3.552 (2) and 3.641 (2) Å

CosAvatar: Consistent and Animatable Portrait Video Tuning with Text Prompt

Recently, text-guided digital portrait editing has attracted more and more attentions. However, existing methods still struggle to maintain consistency across time, expression, and view or require specific data prerequisites. To solve these challenging problems, we propose CosAvatar, a high-quality and user-friendly framework for portrait tuning. With only monocular video and text instructions as input, we can produce animatable portraits with both temporal and 3D consistency. Different from methods that directly edit in the 2D domain, we employ a dynamic NeRF-based 3D portrait representation to model both the head and torso. We alternate between editing the video frames' dataset and updating the underlying 3D portrait until the edited frames reach 3D consistency. Additionally, we integrate the semantic portrait priors to enhance the edited results, allowing precise modifications in specified semantic areas. Extensive results demonstrate that our proposed method can not only accurately edit portrait styles or local attributes based on text instructions but also support expressive animation driven by a source video.Comment: Project page: https://ustc3dv.github.io/CosAvatar