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Chiral Phosphoric Acid Catalyzed Enantioselective Decarboxylative Alkylation of β‑Keto Acids with 3‑Hydroxy-3-indolyloxindoles
A chiral phosphoric acid catalyzed
enantioselective decarboxylative
alkylation of β-keto acids with 3-hydroxy-3-indolyloxindoles
is described in this context. This method tolerates a series of aromatic
and aliphatic β-keto acids as well as substituted 3-hydroxy-3-indolyloxindoles,
affording the corresponding chiral 3-functionalized 3-indolyloxindoles
in high yields (up to 98%) and enantioselectivities (up to 99% ee)