Chiral Phosphoric Acid Catalyzed Enantioselective Decarboxylative Alkylation of β‑Keto Acids with 3‑Hydroxy-3-indolyloxindoles

Abstract

A chiral phosphoric acid catalyzed enantioselective decarboxylative alkylation of β-keto acids with 3-hydroxy-3-indolyloxindoles is described in this context. This method tolerates a series of aromatic and aliphatic β-keto acids as well as substituted 3-hydroxy-3-indolyloxindoles, affording the corresponding chiral 3-functionalized 3-indolyloxindoles in high yields (up to 98%) and enantioselectivities (up to 99% ee)