24,843 research outputs found

    SDF1 Gene Variation Is Associated with Circulating SDF1 alpha Level and Endothelial Progenitor Cell Number-The Bruneck Study

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    BACKGROUND: Stromal cell-derived factor-1 (SDF1) and its receptor CXC chemokine receptor 4 (CXCR4) play a critical role in progenitor cell homing, mobilization and differentiation. It would be interesting to assess the predictive value of SDF-1alpha level for EPC number, and to ascertain whether there is a relationship between SDF1 gene variation, plasma SDF-1alpha level, and the number and function of circulating EPCs. We also tested whether EPC number and function was related to CXCR4 gene variation. METHODOLOGY AND PRINCIPAL FINDINGS: We genotyped a cohort of individuals who participated in the Bruneck Study for single nucleotide polymorphisms (SNPs) in the SDF1 and CXCR4 genes, and measured blood SDF1alpha level as well as EPC number and function. SDF1alpha levels were correlated with age, gender, alcohol consumption, circulating reticulocyte numbers, and concentrations of matrix metalloproteinase-9, C-reactive protein, cystatin C, fibrinogen and homocytein. In blood samples taken in 2005, EPC number was inversely associated with SDF1alpha level (p<0.001). EPC number in 2005 was also inversely associated with SDF1alpha level in 2000 (p = 0.009), suggesting a predictive value of plasma SDF1alpha level for EPC number. There was an association between the SDF1 gene rs2297630 SNP A/A genotype, increased SDF1alpha level (p = 0.002) and lower EPC number (p = 0.006). CONCLUSIONS: Our data indicate that a SDF1 gene variation (rs2297630) has an influence on SDF1alpha level and circulating EPC number, and that plasma SDF1alpha level is a predictor of EPC number

    Theoretical spin-wave dispersions in the antiferromagnetic phase AF1 of MnWO4_4 based on the polar atomistic model in P2

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    The spin wave dispersions of the low temperature antiferromagnetic phase (AF1) MnWO4_4 have been numerically calculated based on the recently reported non-collinear spin configuration with two different canting angles. A Heisenberg model with competing magnetic exchange couplings and single-ion anisotropy terms could properly describe the spin wave excitations, including the newly observed low-lying energy excitation mode Ο‰2\omega_2=0.45 meV appearing at the magnetic zone centre. The spin wave dispersion and intensities are highly sensitive to two differently aligned spin-canting sublattices in the AF1 model. Thus this study reinsures the otherwise hardly provable hidden polar character in MnWO4_4.Comment: 7 pages, 5 figure

    Excitation of nonlinear ion acoustic waves in CH plasmas

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    Excitation of nonlinear ion acoustic wave (IAW) by an external electric field is demonstrated by Vlasov simulation. The frequency calculated by the dispersion relation with no damping is verified much closer to the resonance frequency of the small-amplitude nonlinear IAW than that calculated by the linear dispersion relation. When the wave number kΞ»De k\lambda_{De} increases, the linear Landau damping of the fast mode (its phase velocity is greater than any ion's thermal velocity) increases obviously in the region of Ti/Te<0.2 T_i/T_e < 0.2 in which the fast mode is weakly damped mode. As a result, the deviation between the frequency calculated by the linear dispersion relation and that by the dispersion relation with no damping becomes larger with kΞ»Dek\lambda_{De} increasing. When kΞ»Dek\lambda_{De} is not large, such as kΞ»De=0.1,0.3,0.5k\lambda_{De}=0.1, 0.3, 0.5, the nonlinear IAW can be excited by the driver with the linear frequency of the modes. However, when kΞ»Dek\lambda_{De} is large, such as kΞ»De=0.7k\lambda_{De}=0.7, the linear frequency can not be applied to exciting the nonlinear IAW, while the frequency calculated by the dispersion relation with no damping can be applied to exciting the nonlinear IAW.Comment: 10 pages, 9 figures, Accepted by POP, Publication in August 1

    Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study

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    BACKGROUND AND PURPOSE: Previous work has shown that soluble heat shock protein 60 (HSP60; sHSP60), present in circulating blood, is associated with carotid atherosclerosis. In the current evaluation, we tested the hypothesis that sHSP60 levels are associated with the progression of carotid arteriosclerosis, prospectively. METHODS: The association of sHSP60 with early atherogenesis (5-year development and progression of nonstenotic carotid plaques) was investigated as part of the population-based prospective Bruneck Study. The current study focused on the follow-up period between 1995 and 2000 and, thus, included 684 subjects. RESULTS: sHSP60 levels measured in 1995 and 2000 were highly correlated (r=0.40; P<0.001), indicating consistency over a 5-year period. Circulating HSP60 levels were significantly correlated with antilipopolysaccharide and anti-HSP60 antibodies. It was also elevated in subjects with chronic infection (top quintile group of HSP60, among subjects with and without chronic infection: 23.8% versus 17.0%; P=0.003 after adjustment for age and sex). HSP60 levels were significantly associated with early atherogenesis, both in the entire population (multivariate odds ratio, for a comparison between quintile group V versus I+II: 2.0 [1.2 to 3.5] and the subgroup free of atherosclerosis at the 1995 baseline: 3.8 [1.6 to 8.9]). The risk of early atherogenesis was additionally amplified when high-sHSP60 and chronic infection were present together. CONCLUSIONS: Our study provides the first prospective data confirming an association between high levels of sHSP60 and early carotid atherosclerosis. This possibly indicates an involvement of sHSP60 in activating proinflammatory processes associated with early vessel pathology

    Exotic phase diagram of a topological quantum system

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    We study the quantum phase transitions (QPTs) in the Kitaev spin model on a triangle-honeycomb lattice. In addition to the ordinary topological QPTs between Abelian and non-Abelian phases, we find new QPTs which can occur between two phases belonging to the same topological class, namely, either two non-Abelian phases with the same Chern number or two Abelian phases with the same Chern number. Such QPTs result from the singular behaviors of the nonlocal spin-spin correlation functions at the critical points.Comment: 10 pages, 5 figure
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