10,510 research outputs found
Cosmic e^\pm, \bar p, \gamma and neutrino rays in leptocentric dark matter models
Dark matter annihilation is one of the leading explanations for the recently
observed excesses in cosmic rays by PAMELA, ATIC, FERMI-LAT and HESS.
Any dark matter annihilation model proposed to explain these data must also
explain the fact that PAMELA data show excesses only in spectrum but
not in anti-proton. It is interesting to ask whether the annihilation mode into
anti-proton is completely disallowed or only suppressed at low energies. Most
models proposed have negligible anti-protons in all energy ranges. We show that
the leptocentric dark matter model can explain the
excesses with suppressed anti-proton mode at low energies, but at higher
energies there are sizable anti-proton excesses. Near future data from PAMELA
and AMS can provide crucial test for this type of models. Cosmic ray
data can further rule out some of the models. We also show that this model has
interesting cosmic neutrino signatures.Comment: Latex 20 pages and five figures. References adde
Perspective of Galactic dark matter subhalo detection on Fermi from the EGRET observation
The perspective of the detectability of Galactic dark matter subhaloes on the
Fermi satellite is investigated in this work. Under the assumptions that dark
matter annihilation accounts for the "GeV excess" of the Galactic diffuse
-rays discovered by EGRET and the -ray flux is dominated by the
contribution from subhaloes of dark matter, we calculate the expected number of
dark matter subhaloes that Fermi may detect. We show that Fermi may detect a
few tens to several hundred subhaloes in 1-year all sky survey. Since EGRET
observation is taken as a normalization, this prediction is independent of the
particle physics property of dark matter. The uncertainties of the prediction
are discussed in detail. We find that the major uncertainty comes from the mass
function of subhaloes, i.e., whether the subhaloes are "point like" (high-mass
rich) or "diffuse like" (low-mass rich). Other uncertainties like the
background estimation and the observational errors will contribute a factor of
.Comment: 16 pages, 4 figures and 1 table, accepted for publication in Chinese
Physics
Diffuse -rays and flux from dark matter annihilation -- a model for consistent results with EGRET and cosmic ray data
In this work we develop a new propagation model for the Galactic cosmic rays
based on the GALPROP code, including contributions from dark matter
annihilation. The model predicts compatible Galactic diffuse ray
spectra with EGRET data in all sky regions. It also gives consistent results of
the diffuse ray longitude and latitude distributions. Further the
results for B/C, Be/Be, proton, electron and antiproton spectra are
also consistent with cosmic ray measurements. In the model we have taken a
universal proton spectrum throughout the Galaxy without introducing large
fluctuation for the proton energy loss is negligible. The dark matter
annihilation signals are `boosted' after taking the contribution from subhalos
into account. Another interesting feature of the model is that it gives better
description of the diffuse rays when taking the source distribution
compatible with supernova remnants data, which is different from previous
studies.Comment: 29 pages, 13 figures; the published versio
Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis.
BackgroundIn multiple sclerosis (MS) and its widely used animal model, experimental autoimmune encephalomyelitis (EAE), autoreactive T cells contribute importantly to central nervous system (CNS) tissue damage and disease progression. Promoting apoptosis of autoreactive T cells may help eliminate cells responsible for inflammation and may delay disease progression and decrease the frequency and severity of relapse. Programmed cell death 5 (PDCD5) is a protein known to accelerate apoptosis in response to various stimuli. However, the effects of recombinant human PDCD5 (rhPDCD5) on encephalitogenic T cell-mediated inflammation remain unknown.MethodsWe examined the effects of intraperitoneal injection of rhPDCD5 (10 mg/kg) on EAE both prophylactically (started on day 0 post-EAE induction) and therapeutically (started on the onset of EAE disease at day 8), with both of the treatment paradigms being given every other day until day 25. Repeated measures two-way analysis of variance was used for statistical analysis.ResultsWe showed that the anti-inflammatory effects of rhPDCD5 were due to a decrease in Th1/Th17 cell frequency, accompanied by a reduction of proinflammatory cytokines, including IFN-γ and IL-17A, and were observed in both prophylactic and therapeutic regimens of rhPDCD5 treatment in EAE mice. Moreover, rhPDCD5-induced apoptosis of myelin-reactive CD4+ T cells, along with the upregulation of Bax and downregulation of Bcl-2, and with activated caspase 3.ConclusionsOur data demonstrate that rhPDCD5 ameliorates the autoimmune CNS disease by inhibiting Th1/Th17 differentiation and inducing apoptosis of predominantly pathogenic T cells. This study provides a novel mechanism to explain the effects of rhPDCD5 on neural inflammation. The work represents a translational demonstration that rhPDCD5 has prophylactic and therapeutic properties in a model of multiple sclerosis
Higgs Decay with Minimal Flavor Violation
We consider the tentative indication of flavor-violating Higgs boson decay
recently reported in the CMS experiment within the framework of
minimal flavor violation. Specifically, we adopt the standard model extended
with the seesaw mechanism involving right-handed neutrinos plus effective
dimension-six operators satisfying the minimal flavor violation principle in
the lepton sector. We find that it is possible to accommodate the CMS
signal interpretation provided that the right-handed neutrinos
couple to the Higgs boson in some nontrivial way. We take into account
empirical constraints from other lepton-flavor-violating processes and discuss
how future searches for the decay and conversion in
nuclei may further probe the lepton-flavor-violating Higgs couplings.Comment: 15 pages, no figures, minor errors corrected, references added,
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