2,432 research outputs found
ROC Surfaces in the Presence of Verification Bias
In diagnostic medicine, the Receiver Operating Characteristic (ROC) surface is one of the established tools for assessing the accuracy of a diagnostic test in discriminating three disease states, and the volume under the ROC surface has served as a summary index for diagnostic accuracy. In practice, the selection for definitive disease examination may be based on initial test measurements, and induces verification bias in the assessment. We propose here a nonparametric likelihood-based approach to construct the empirical ROC surface in the presence of differential verification, and to estimate the volume under the ROC surface. Estimators of the standard deviation are derived by both the Fisher\u27s Information and Jack-knife method, and their relative accuracy is evaluated in an extensive simulation study. The methodology is further extended to incorporate discrete baseline covariates in the selection process, and to compare the accuracy of a pair of diagnostic tests. We apply the proposed method to compare the diagnostic accuracy between Mini-Mental State Examination and clinical evaluation of dementia, in discriminating among three disease states of Alzheimer\u27s disease
1,3-Bis(2-nitrophenoxy)propan-2-ol
In the title compound, C15H14N2O7, the planes of the two benzene rings form a dihedral angle of 33.16 (17)°. In the crystal, intermolecular hydrogen bonds involveing the OH group and nitro O atoms link the molecules into chains propagating along the a axis
Cooling mechanical resonators to quantum ground state from room temperature
Ground-state cooling of mesoscopic mechanical resonators is a fundamental
requirement for test of quantum theory and for implementation of quantum
information. We analyze the cavity optomechanical cooling limits in the
intermediate coupling regime, where the light-enhanced optomechanical coupling
strength is comparable with the cavity decay rate. It is found that in this
regime the cooling breaks through the limits in both the strong and weak
coupling regimes. The lowest cooling limit is derived analytically at the
optimal conditions of cavity decay rate and coupling strength. In essence,
cooling to the quantum ground state requires , with being the mechanical quality factor and
being the thermal phonon number. Remarkably, ground-state
cooling is achievable starting from room temperature, when mechanical
-frequency product , and both of the
cavity decay rate and the coupling strength exceed the thermal decoherence
rate. Our study provides a general framework for optimizing the backaction
cooling of mesoscopic mechanical resonators
Plant diversity of Southeast Asia-II
The special issue of plant diversity in Southeast Asia will focus on the documentation of new discoveries in SE Asia. There are four global biodiversity hotspots in Southeast Asia. Although there are many plans to protect this rich biodiversity, however, the rich biodiversity in SE Asia is under threat due to economic development and population growth. There is a huge gap between our knowledge and biodiversity in SE Asia. During the last six investigations, many new taxa, including new species, new genera, have been discovered. This special issue will bring the rich but little known biodiversity to the public and protect them
Description of a Sulfitobacter Strain and Its Extracellular Cyclodipeptides
A marine bacterium M44 was separated from 30 m deep seawater in the East China Sea (26° 28.3′ N 122° 29.0′ E) in 2006. 16S rDNA gene sequence comparison showed that the strain M44 was a member of the genus Sulfitobacter and highly similar to KMM 3554T. A series of experiments demonstrated that this strain M44 had many distinctive characteristics: its cells were gram-negative and mesophilic; its colonies were slightly yellowish, round, convex, and smooth; and it could grow at 10–28°C, pH 6.0–10.0, and in the presence of 0–12.5% (w/v) NaCl; the optimum growth conditions were 25°C and pH 7.0, and the optimum Na+ concentration was 2.5%. In addition, strain M44 contained 18 : 1 ω7c, 11 methyl 18 : 1 ω7c and 16 : 0 fatty acids as major fatty acids, and the genomic DNA G+C content was 58.04 mol%. According to our results of the secondary metabolites, six cyclodipeptides were isolated from the strain M44, which were Cyclo (Val-Leu), Cyclo (Phe-Val), Cyclo (Phe-Leu), Cyclo (Leu-Ile), Cyclo (Phe-Ile), and Cyclo (Trp-Pro). It is the first study of secondary metabolites isolated from this genus
Quantum electrodynamics in a whispering-gallery microcavity coated with a polymer nanolayer
Quasi-transverse-electric and -transverse-magnetic fundamental whispering
gallery modes in a polymer-coated silica microtoroid are theoretically
investigated and demonstrated to possess very high-quality factors. The
existence of a nanometer-thickness layer not only evidently reduces the cavity
mode volume but also draws the maximal electric field's position of the mode to
the outside of the silica toroid, where single quantum dots or nanocrystals are
located. Both effects result in a strongly enhanced coherent interaction
between a single dipole (for example, a single defect center in a diamond
crystal) and the quantized cavity mode. Since the coated microtoroid is highly
feasible and robust in experiments, it may offer an excellent platform to study
strong-coupling cavity quantum electrodynamics, quantum information, and
quantum computation
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