2-(5,6-Dibromo-7-methyl-3H-imidazo[4,5-b]pyridin-2-yl)phenol

In the title compound, C13H9Br2N3O, the mol­ecular skeleton, influenced by an intra­molecular O—H⋯N hydrogen bond, is roughly planar, with a mean deviation of 0.033 Å. In the crystal, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into chains propagating in [100]. Weak inter­molecular π–π inter­actions [centroid–centroid distances = 3.760 (3) and 3.723 (3) Å] further consolidate the packing

Corporate Turnarounds in the High-tech Industry in UK

Prior research on corporate turnaround relates to those organizations that have managed to move from poor performance to high performance within a relatively short time period by a case-study approach. The study also explores the role of leadership as a key factor in making turnaround successful as characterized by the change in CEO and in the board of directors. Finally, it explores the incentive systems of those firms during the turnaround. This study analyzed six public companies which consist of 3 cases of turnaround and 3 cases of sustained good performance cases in the UK High-tech industry, over a period of 2000-2008. In the case study, I found the success of turnaround is primarily due to the rational utilization of appropriate turnaround strategies (i.e. new product development and/or acquisition) to reflect those external and/or internal changes that have a significant influent on corporate decline. Also it discovered that there is a positive relationship between the changes of the board members and firm performance during turnaround attempts. Finally, no any change has been appeared in the incentive system during the turnaround. Key words: Strategy, Turnaround, Leadership, High-tech industr

Corporate Turnarounds in the High-tech Industry in UK

Prior research on corporate turnaround relates to those organizations that have managed to move from poor performance to high performance within a relatively short time period by a case-study approach. The study also explores the role of leadership as a key factor in making turnaround successful as characterized by the change in CEO and in the board of directors. Finally, it explores the incentive systems of those firms during the turnaround. This study analyzed six public companies which consist of 3 cases of turnaround and 3 cases of sustained good performance cases in the UK High-tech industry, over a period of 2000-2008. In the case study, I found the success of turnaround is primarily due to the rational utilization of appropriate turnaround strategies (i.e. new product development and/or acquisition) to reflect those external and/or internal changes that have a significant influent on corporate decline. Also it discovered that there is a positive relationship between the changes of the board members and firm performance during turnaround attempts. Finally, no any change has been appeared in the incentive system during the turnaround. Key words: Strategy, Turnaround, Leadership, High-tech industr

Dynamic analysis of reciprocating compressor system with translational clearance and time-varying load

Dynamic behavior of reciprocating compressor system, with translational clearance between the crosshead and guide under time-varying cylinder load, is investigated. In order to analyze the dynamic response of the system with translational clearance, a novel nonlinear dynamic model is established based on the Lagrangian approach. The numerical solution of the dynamic equation is calculated by the Runge-Kutta method. The results show that the translational clearance has a great effect on the reciprocating compressor, and the more the translational clearance, the great the influence. Moreover, the phase space of the crosshead reveals that the reciprocating compressor system with translational clearance has chaotic characteristics

Simultaneous Determination of Co-formulated Matrine and Secnidazole in Suppositories by Reverse Phase High Performance Liquid Chromatography

Purpose: To develop and validate a new, simple, sensitive and accurate high performance liquid chromatographic (HPLC) method for the simulataneous determination of matrine and secnidazole in suppositories.Methods: The method involved using a SinoChoom ODS-BP C18 column (5 ƒÊm, 4.6 mm ~ 200 mm) and mobile phase consisting of  acetonitrile.triethylamine (0.05 %) in 0.025 mol/L KH2PO4 (20:80, v/v).The flow rate was 1 mL/min and detection was monitored at 210 and 311 nm for matrine and secnidazole, respectively. Total run time was 10 min and the column was maintained at 35 oC.Results: The excipients in the suppository did not interfere with the drug peaks. Matrine was eluted at a retention time (RT) of 4.30 min while linearity for the quantification of drug was obtained in the concentration range of 10.0 - 100.0 ƒÊg/mL (r2 = 0.9991). Secnidazole was eluted at a retention time (tr) of 6.69 min and linearity for the quantification of the drug was obtained in the concentration range of 10.0 - 150.0 ƒÊg/mL (r2 = 0.9993). Intra- and inter-day variations were < 1.0 % for both matrine andsecnidazole.Conclusion: The developed HPLC method was validated according to International Conference on Harmonisation (ICH) guidelines and proved to be suitable for the simultaneous determination of matrine and secnidazole in suppositories.Keywords: Matrine, Secnidazole, Suppository, HPLC, Assa

On Kalman Smoothing for Wireless Sensor Networks Systems with Multiplicative Noises

The paper deals with Kalman (or H2) smoothing problem for wireless sensor networks (WSNs) with multiplicative noises. Packet loss occurs in the observation equations, and multiplicative noises occur both in the system state equation and the observation equations. The Kalman smoothers which include Kalman fixed-interval smoother, Kalman fixedlag smoother, and Kalman fixed-point smoother are given by solving Riccati equations and Lyapunov equations based on the projection theorem and innovation analysis. An example is also presented to ensure the efficiency of the approach. Furthermore, the proposed three Kalman smoothers are compared

Selection of variant viruses during replication and transmission of H7N1 viruses in chickens and turkeys

AbstractThe influence of different glycosylation patterns of the haemagglutinin glycoprotein of H7N1 avian influenza viruses on virus replication in vivo was examined. Experimental infection of chickens and turkeys was carried out with H7N1 avian influenza viruses with alternative sites of glycosylation in the haemagglutinin and infected birds were sampled daily by swabbing the buccal and cloacal cavities. cDNAs of the HA1 coding region of the HA gene were prepared from the swabs and cloned into plasmids. Sequencing multiple plasmids made from individual swabs taken over the period of virus shedding showed that viruses with specific patterns of glycosylation near the receptor binding site were stable when birds were infected with a single variant, but when presented with a mixed population of viruses encoding differing patterns of glycosylation a specific variant was rapidly selected in the infected host

Multi-normal-mode splitting of a cavity in the presence of atoms -- towards the superstrong coupling regime

Multi-normal-mode splitting peaks are experimentally observed in a system with Doppler-broadened two-level atoms inside a relatively long optical cavity. In this system, the atoms-cavity interaction can reach the ``superstrong coupling" condition with atoms-cavity coupling strength $g\sqrt{N}$ to be near or larger than the cavity free-spectral range $\Delta_{FSR}$. In such case, normal-mode splitting can occur in many cavity longitudinal modes to generate the multi-normal-mode splitting peaks, which can be well explained by the linear dispersion enhancement due to the largely increased atomic density in the cavity. Many new interesting phenomena might come out of this superstrong atoms-cavity coupling regime.Comment: 4 pages, 5 figures. appear in Phys. Rev.

Determination, source analysis and preliminary risk assessment of benzoic acid in rice wine

Objective To analyze the concentration and source of benzoic acid in rice wine and evaluate the health risk of dietary benzoic acid intake from rice wine among adult consumers in China. Methods 231 samples of rice wine and 15 samples of raw materials were collected from five main rice wine production areas in China, including Shandong, Zhejiang, Jiangsu, Fujian and Shanghai; the content of benzoic acid and its precursors were determined by high performance liquid chromatography; the sources of benzoic acid in rice wine were analyzed by the benzaldehyde and phenylalanine simulation test and the real sample acceleration test; the benzoic acid intake among adult consumers was evaluated by simple distribution assessment method. Results In all rice wine samples, the detection rate of benzoic acid was 99.13% (229/231), the concentration range of benzoic acid was ND (not detectable) -37.00 mg/L, and the average was 2.28 mg/L. In 98 end products, the detection rate of benzoic acid was 100.00% (98/98), the concentration range of benzoic acid was ND-1.60 mg/L, and the average was 0.52 mg/L; in 133 base wine samples, the detection rate of benzoic acid was 98.50% (131/133), the content range of benzoic acid was ND-37.00 mg/L, and the average was 3.58 mg/L. The result of source analysis showed that the benzoic acid in rice wine mainly came from raw materials, degradation of phenylalanine and oxidation of benzaldehyde. Exposure assessment result showed that the average exposure of benzoic acid for rice wine consumers in China was 0.001 mg/kg BW, accounting for 0.02% of the acceptable daily intake (ADI); and the 95th percentile was 0.005 mg/kg BW, accounting for 0.1% of the ADI. Conclusion The detection rate of benzoic acid in rice wine was high but the concentration was low. Source analysis result indicated that benzoic acid in rice wine mainly came from raw materials, degradation of phenylalanine and oxidation of benzaldehyde; the health risk of benzoic acid exposure to adult rice wine consumers in China was low