Ring roads and urban biodiversity: distribution of butterflies in urban parks in Beijing city and correlations with other indicator species

The capital of China, Beijing, has a history of more than 800 years of urbanization, representing a unique site for studies of urban ecology. Urbanization can severely impact butterfly communities, yet there have been no reports of the species richness and distribution of butterflies in urban parks in Beijing. Here, we conducted the first butterfly survey in ten urban parks in Beijing and estimated butterfly species richness. Subsequently, we examined the distribution pattern of butterfly species and analyzed correlations between butterfly species richness with park variables (age, area and distance to city center), and richness of other bioindicator groups (birds and plants). We collected 587 individual butterflies belonging to 31 species from five families; 74% of the species were considered cosmopolitan. The highest butterfly species richness and abundance was recorded at parks located at the edge of city and species richness was significantly positively correlated with distance from city center (p  0.05). Our study provides the first data of butterfly species in urban Beijing, and serves as a baseline for further surveys and conservation efforts

MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3

Steroid-induced osteonecrosis of femoral head (ONFH) is a serious complication of glucocorticoid (GC) use. We investigated the differential expression of miRs in the mesenchymal stem cells (MSCs) of patients with ONFH, and aimed to explain the relationship between GC use and the development of MSC dysfunction in ONFH. Cells were collected from bone marrow of patients with ONFH. Samples were assigned to either GCs Group or Control Group at 1:1 matched with control. We then used miRNA microarray analysis and real-time PCR to identify the differentially expressed miRs. We also induced normal MSCs with GCs to verify the differential expression above. Subsequently, we selected some of the miRs for further studies, including miRNA target and pathway prediction, and functional analysis. We discovered that miR-708 was upregulated in ONFH patients and GC-treated MSCs. SMAD3 was identified as a direct target gene of miR-708, and functional analysis demonstrated that miR-708 could markedly suppress osteogenic differentiation and adipogenesis differentiation of MSCs. Inhibition of miR-708 rescued the suppressive effect of GC on osteonecrosis. Therefore, we determined that GC use resulted in overexpression of miR-708 in MSCs, and thus, targeting miR-708 may serve as a novel therapeutic biomarker for the prevention and treatment of ONFH

Research on the Method of Feature-Based Multi-scale Vector Data Model

International audienceMulti-scale representation of spatial data is a research focus in GIS, while building multi-scale data model is a key to implementing multi-scale representation of vector data. In view of the shortcomings of existing multi-scale data model in geographical cognition and special analysis, this paper puts forward a method of feature-based, and studies on it qualitatively from definition, description and extraction. Compared to conventional single-scale E-R model, in this paper, the key strategies of building multi-scale conceptual model are put forward. Deeply study and analysis are applied on abstraction and expression of multiple geometric characteristics, of multi-attribution, and of semantic relation among different scales,and the design of feature-based multi-scale conceptual model is realized. Finally, the object-oriented multi-scale logic model is researched, which lays a theoretical foundation for building the feature-based multi-scale vector data model

Synergistic neuroprotective effects of two herbal ingredients via CREB-dependent pathway

As two natural oligosaccharide esters, 3,6’-Disinapoyl sucrose (DISS) and tenuifolisideA (TFSA) are originating from the root of Polygala tenuifolia Willd, a traditional Chinese medicine used in treatment of mental disorders. Previous reports have shown that both of them possess in vitro neuroprotective effects by stimulating different upstream pathways related with cyclic AMP-responsive element-binding protein (CREB). In the present study, we investigated the additive neuroprotective effects of DISS and TFSA on Glu-induced damage of SY5Y cells and purposed the possible underlying mechanism. The interaction between DISS and TFSA showed a clear-cut synergistic effect as evidenced by combination index (CI). Additional evidence from biochemical (NOS activity) assays confirmed their additive inhibition on the Glu-induced NOS hyperactivation. Moreover, we showed that co-treatment of DISS and TFSA resulted in an additively up-regulated phosphorylation of CREB as well as increased expressions of CRTC1 and BDNF. Neuroprotective effects of DISS and TFSA on Glu-induced decrease in cell viability were blocked by MAPK/ERK1/2 inhibitor (U0126) and PI3-K inhibitor (LY290042). Nevertheless, the CRTC1 or BDNF expression induced by these two compounds was significantly reduced in the presence of either ERK or PI3-K inhibitor, indicating that the two oligosaccharide esters shared some common pathways in the regulation of CREB-BDNF pathway. Taken together, we, for the first time, showed that DISS and TFSA exerted the additive neuroprotective effects on CREB-BDNF signaling pathway through complementary mechanisms

Magnetic Flux Circulation in the Saturnian Magnetosphere as Constrained by Cassini Observations in the Inner Magnetosphere

In steady state, magnetic flux conservation must be maintained in Saturn- s magnetosphere. The Enceladus plumes add mass to magnetic flux tubes in the inner magnetosphere, and centrifugal force pulls the mass- loaded flux tubes outward. Those flux tubes are carried outward to the magnetotail where they deposit their mass and return to the mass loading region. It may take days for the magnetic flux to be carried outward to the tail, but the return of the nearly empty flux tubes can last only several hours, with speeds of inward motion around 200 km/s. Using time sequences of Cassini particle count rate, the difference in curvature drift and gradient drift is accounted for to determine the return speed, age, and starting dipole L- shell of return flux tubes. Determination of this flux- return process improves our understanding of the magnetic flux circulation at Saturn and provides insight into how other giant planets remove the mass added by their moons.Key PointsTo determine the flux return process, the count rate distributions of ions/electrons inside a flux tube have been studiedWe use a stretched dipolar magnetosphere model and account for the difference in curvature and gradient driftWe estimate the starting dipole L shell of the return flux tubes to be greater than 45Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/171026/1/jgra56837.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/171026/2/jgra56837_am.pd

Exploration of the Ice Giant Systems: A White Paper for NASA's Planetary Science and Astrobiology Decadal Survey 2023-2032

Ice giants are the only unexplored class of planet in our Solar System. Much that we currently know about these systems challenges our understanding of how planets, rings, satellites, and magnetospheres form and evolve. We assert that an ice giant Flagship mission with an atmospheric probe should be a priority for the decade 2023-2032