Fundamental study of central crack mechanism and criterion in cross wedge rolling

Cross wedge rolling (CWR), a novel metal forming process for manufacturing axisymmetric stepped shafts, is widely applied in transport industries. Central crack, the cavity formed in the product centre, is a critical problem, preventing its development in safety-critical industries. However, the understanding of the central crack mechanism is insufficient, and there is not yet a robust fracture criterion to predict its occurrence. This study aims to establish a fundamental understanding of the central crack mechanism and build a robust physically-based fracture criterion. An innovative CWR physical model with plasticine billets was built in house, which allowed the dies to be rapidly 3D printed and the workpiece with specific mechanical properties to be efficiently manufactured. The effects of the stress variables and initial material properties (ductility) on central cracking were investigated by varying the die geometries and billet material compositions, respectively. It is found that the maximum shear stress plays a dominant role in the central crack formation, and with the increase of the material ductility, the central crack transitions from brittle fracture to ductile fracture. A robust physically-based damage model set was proposed, along with a novel material constant calibration method. The reliability of the proposed model was validated quantitively by 60 groups of CWR tests with different materials and die geometries. The proposed calibration method will significantly benefit the industry due to the extremely simplified die geometries. To further understand the central crack mechanism in the practical industry, the microstructural characteristics (e.g., inclusion, grain size and phase composition) of two high-strength steel CWR billets (with/without high possibility to crack) were quantitatively analysed and compared. It is found that central cracking can be effectively avoided by controlling the inclusion content in the CWR billets.Open Acces

Forming-based geometric correction methods for thin-walled metallic components:a selective review

Geometric correction processes contribute to zero-defect manufacturing for improved product quality. Thin-walled metallic components are widely used in numerous applications such as electric vehicles and aircraft due to the lightweight feature, facilitating to achieve zero-emission goals. However, many components suffer geometric imperfections and inaccuracies such as undesired curvatures and twists, seriously affecting subsequent manufacturing operations, for example, automatic welding and assembly. Geometric correction techniques have been established to address these issues, but they have drawn little attention in the scientific community despite their wide applications and urgent demands in the industry. Due to the strict geometric tolerances demanded in high-volume automated production, it is urgent to increase the knowledge needed to develop new techniques to address future industrial challenges. This review paper presents an overview of typical geometric defects in thin-walled components and clarifies the associated underlying generation mechanisms. Attempts have also been made to discuss and categorize geometric correction techniques based on different forming mechanisms. The challenges in correcting complex thin-walled products are discussed. This review paper also provides researchers and engineers with directions to find and select appropriate geometric correction methods to achieve high geometric accuracy for thin-walled metallic components.</p

Involved-field irradiation or elective-nodal irradiation in neoadjuvant chemo-radiotherapy for locally-advanced esophageal cancer: comprehensive analysis for dosimetry, treatment-related complications, impact on lymphocyte, patterns of failure and survival

PurposeTo compare the differences between involved-field irradiation (IFI) and elective nodal irradiation (ENI) in selecting the optimal target area for neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC).Materials and methodsWe retrospectively analyzed 267 patients with LA-ESCC, of whom 165 underwent ENI and 102 underwent IFI. Dosimetry, treatment-related complications, pathological responses, recurrence/metastasis patterns, and survival were compared between the two groups.ResultsThe median follow-up duration was 27.9 months. The R0 resection rates in the IFI and ENI groups were 95.1% and 92.7%, respectively (p=0.441), while the pathological complete response (pCR) rates were 42.2% and 34.5%, respectively (p=0.12). The ENI group received higher radiation doses to the heart (HV30:23.9% vs. 18%, p=0.033) and lungs (LV30:7.7% vs. 4.9%, p&lt;0.001) than the IFI group. Consequently, the ENI group showed a higher incidence of grade 2 or higher radiation pneumonitis (30.3% vs. 17.6%, p=0.004) and pericardial effusion (26.7% vs. 11.8%, p=0.021) than the IFI group. Post-operation fistulas were observed in 3 (2.9%) and 17 cases (10.3%) in the IFI and ENI groups, respectively (p=0.026). In the multivariate analysis, smoking, positive lymph node involvement (pN+), and anastomotic fistula were independent predictors of overall survival (OS). The pN+ patients exhibited a greater propensity for recurrence compared to pN- patients, especially in the first year of follow-up (6.67% vs. 0.56%, p=0.003).ConclusionThe ENI group had a higher incidence of radiation-induced adverse events compared to the IFI group, likely due to the higher radiation doses to normal tissues. Considering the similar disease-free survival (DFS) and OS rates in the two groups, IFI may be suitable for nCRT in patients with LA-ESCC, although further prospective studies are warranted

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase&nbsp;1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation&nbsp;disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age&nbsp; 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score&nbsp; 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc&nbsp;= 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N&nbsp;= 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in&nbsp;Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in&nbsp;Asia&nbsp;and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Experiment and Simulation Verification on the Composite Mode of Enhanced Glulam

The structural glulam used in bridge engineering is huge, which exists many defects by full-scale experimental method to research its relevant properties. Both experiment and simulation verification of ABAQUS were carried to forecast the enhanced composite structure and to reveal the composite enhancement effect of glulam made up of plantation eucalyptus veneers with the reinforced materials of fiberglass mesh and aluminium foil, and the basic mechanical properties were viewed as the evaluation index. The results show that the simulation model is feasible and rational to be applied to choose the better composite mode, and the best enhanced composite structure of glulam is the central seven layers eucalyptus veneers with criss-cross assembling structure, the outer three layers eucalyptus veneers with parallel assembling structure and fiberglass mesh and aluminum foil interval distributed among every two veneers