Computational fluid dynamics modeling of symptomatic intracranial atherosclerosis may predict risk of stroke recurrence.

BackgroundPatients with symptomatic intracranial atherosclerosis (ICAS) of ≥ 70% luminal stenosis are at high risk of stroke recurrence. We aimed to evaluate the relationships between hemodynamics of ICAS revealed by computational fluid dynamics (CFD) models and risk of stroke recurrence in this patient subset.MethodsPatients with a symptomatic ICAS lesion of 70-99% luminal stenosis were screened and enrolled in this study. CFD models were reconstructed based on baseline computed tomographic angiography (CTA) source images, to reveal hemodynamics of the qualifying symptomatic ICAS lesions. Change of pressures across a lesion was represented by the ratio of post- and pre-stenotic pressures. Change of shear strain rates (SSR) across a lesion was represented by the ratio of SSRs at the stenotic throat and proximal normal vessel segment, similar for the change of flow velocities. Patients were followed up for 1 year.ResultsOverall, 32 patients (median age 65; 59.4% males) were recruited. The median pressure, SSR and velocity ratios for the ICAS lesions were 0.40 (-2.46-0.79), 4.5 (2.2-20.6), and 7.4 (5.2-12.5), respectively. SSR ratio (hazard ratio [HR] 1.027; 95% confidence interval [CI], 1.004-1.051; P = 0.023) and velocity ratio (HR 1.029; 95% CI, 1.002-1.056; P = 0.035) were significantly related to recurrent territorial ischemic stroke within 1 year by univariate Cox regression, respectively with the c-statistics of 0.776 (95% CI, 0.594-0.903; P = 0.014) and 0.776 (95% CI, 0.594-0.903; P = 0.002) in receiver operating characteristic analysis.ConclusionsHemodynamics of ICAS on CFD models reconstructed from routinely obtained CTA images may predict subsequent stroke recurrence in patients with a symptomatic ICAS lesion of 70-99% luminal stenosis

Eclipsing Binaries From the CSTAR Project at Dome A, Antarctica

The Chinese Small Telescope ARray (CSTAR) has observed an area around the Celestial South Pole at Dome A since 2008. About $20,000$ light curves in the i band were obtained lasting from March to July, 2008. The photometric precision achieves about 4 mmag at i = 7.5 and 20 mmag at i = 12 within a 30 s exposure time. These light curves are analyzed using Lomb--Scargle, Phase Dispersion Minimization, and Box Least Squares methods to search for periodic signals. False positives may appear as a variable signature caused by contaminating stars and the observation mode of CSTAR. Therefore the period and position of each variable candidate are checked to eliminate false positives. Eclipsing binaries are removed by visual inspection, frequency spectrum analysis and locally linear embedding technique. We identify 53 eclipsing binaries in the field of view of CSTAR, containing 24 detached binaries, 8 semi-detached binaries, 18 contact binaries, and 3 ellipsoidal variables. To derive the parameters of these binaries, we use the Eclipsing Binaries via Artificial Intelligence (EBAI) method. The primary and the secondary eclipse timing variations (ETVs) for semi-detached and contact systems are analyzed. Correlated primary and secondary ETVs confirmed by false alarm tests may indicate an unseen perturbing companion. Through ETV analysis, we identify two triple systems (CSTAR J084612.64-883342.9 and CSTAR J220502.55-895206.7). The orbital parameters of the third body in CSTAR J220502.55-895206.7 are derived using a simple dynamical model.Comment: 41 pages, 12 figures; published online in ApJ

The First Release of the CSTAR Point Source Catalog from Dome A, Antarctica

In 2008 January the 24th Chinese expedition team successfully deployed the Chinese Small Telescope ARray (CSTAR) to DomeA, the highest point on the Antarctic plateau. CSTAR consists of four 14.5cm optical telescopes, each with a different filter (g, r, i and open) and has a 4.5degree x 4.5degree field of view (FOV). It operates robotically as part of the Plateau Observatory, PLATO, with each telescope taking an image every 30 seconds throughout the year whenever it is dark. During 2008, CSTAR #1 performed almost flawlessly, acquiring more than 0.3 million i-band images for a total integration time of 1728 hours during 158 days of observations. For each image taken under good sky conditions, more than 10,000 sources down to 16 mag could be detected. We performed aperture photometry on all the sources in the field to create the catalog described herein. Since CSTAR has a fixed pointing centered on the South Celestial Pole (Dec =-90 degree), all the sources within the FOV of CSTAR were monitored continuously for several months. The photometric catalog can be used for studying any variability in these sources, and for the discovery of transient sources such as supernovae, gamma-ray bursts and minor planets.Comment: 1 latex file and 9 figures The paper is accepted by PAS

The effects of ECMO on neurological function recovery of critical patients: A double-edged sword

Extracorporeal membrane oxygenation (ECMO) played an important role in the treatment of patients with critical care such as cardiac arrest (CA) and acute respiratory distress syndrome. ECMO is gradually showing its advantages in terms of speed and effectiveness of circulatory support, as it provides adequate cerebral blood flow (CBF) to the patient and ensures the perfusion of organs. ECMO enhances patient survival and improves their neurological prognosis. However, ECMO-related brain complications are also important because of the high risk of death and the associated poor outcomes. We summarized the reported complications related to ECMO for patients with CA, such as north–south syndrome, hypoxic–ischemic brain injury, cerebral ischemia–reperfusion injury, impaired intracranial vascular autoregulation, embolic stroke, intracranial hemorrhage, and brain death. The exact mechanism of ECMO on the role of brain function is unclear. Here we review the pathophysiological mechanisms associated with ECMO in the protection of neurologic function in recent years, as well as the ECMO-related complications in brain and the means to improve it, to provide ideas for the treatment of brain function protection in CA patients

Planetary transit candidates in the CSTAR field: analysis of the 2008 data

The Chinese Small Telescope ARray (CSTAR) is a group of four identical, fully automated, static 14.5 cm telescopes. CSTAR is located at Dome A, Antarctica and covers 20 deg2 of sky around the South Celestial Pole. The installation is designed to provide high-cadence photometry for the purpose of monitoring the quality of the astronomical observing conditions at Dome A and detecting transiting exoplanets. CSTAR has been operational since 2008, and has taken a rich and high-precision photometric data set of 10,690 stars. In the first observing season, we obtained 291,911 qualified science frames with 20 s integrations in the i band. Photometric precision reaches 4 mmag at 20 s cadence at i = 7.5 and is 20 mmag at i = 12. Using robust detection methods, 10 promising exoplanet candidates were found. Four of these were found to be giants using spectroscopic follow-up. All of these transit candidates are presented here along with the discussion of their detailed properties as well as the follow-up observations

Does Population Mobility Contribute to Urbanization Convergence? Empirical Evidence from Three Major Urban Agglomerations in China

Population mobility accelerates urbanization convergence and mitigates the negative impact of the spatial agglomeration effect on urbanization convergence, which is the most important conclusion in this paper. Taking 38 cities in China’s three urban agglomerations (the Yangtze River Delta, the Pearl River Delta, and the Beijing–Tianjin–Hebei region) from 2005 to 2016 as research subjects, the study first shows that there is a large gap in the level of urbanization between the three major urban agglomerations, but the gap has been constantly narrowed and presents a trend of absolute convergence and conditional convergence. Furthermore, without adding a population mobility variable, the combination of the diffusion effect of high-urbanization cities and the high growth rate of low-urbanization cities causes the inter-regional urbanization level to be continuously convergent in the Yangtze River Delta region; however, the combination of the agglomeration effect of high-urbanization cities and the high growth rate of low-urbanization cities causes the inter-regional urbanization to be divergent in the Pearl River Delta and the Beijing–Tianjin–Hebei region. Under the influence of population mobility, the “catch-up” effect in low-urbanization regions is greater than the agglomeration effect in high-urbanization regions, which promotes the continuous convergence of inter-regional urbanization

Vibration Response Analysis of Overhead System Regarding Train-Track-Bridge Dynamic Interaction

Based on the paucity of studies on the analysis of the coupled vibration response of the train-track-overhead System, in this article, finite element software ABAQUS was integrated with multi-body dynamics software, Universal Mechanism (UM), to construct a joint simulation model of the train-track overhead system under a railway line, with the focus on the investigation of the influence of different track irregularity levels, speeds and damping coefficients on the coupled vibration response of the vehicle-track-overhead system. The findings demonstrate that the response of the train body is sensitive to track irregularity, which primarily impacts the safety index of train operation. The results also suggest that the level of track irregularity should be rigorously regulated above AAR5 during construction. The train-track-overhead system functions well and satisfies the overhead system’s design requirements when the train travels through the reinforced line at a speed of no more than 60 km/h. When the train speed is 100 km/h, the vertical acceleration exceeds the limit for the “I” overhead system. There is a possibility of excessive lateral acceleration of the train body and excessive lateral force of the wheel and rail when the train speed is greater than 60 km/h, which endangers the safety of the driver. While it has little effect on the mid-span and vertical displacements, the damping factor of the bridge has a substantial impact on the vertical acceleration and mid-span acceleration of the vertical and horizontal beams. The study’s findings provide useful guidance

Vibration Response Analysis of Overhead System Regarding Train-Track-Bridge Dynamic Interaction

Based on the paucity of studies on the analysis of the coupled vibration response of the train-track-overhead System, in this article, finite element software ABAQUS was integrated with multi-body dynamics software, Universal Mechanism (UM), to construct a joint simulation model of the train-track overhead system under a railway line, with the focus on the investigation of the influence of different track irregularity levels, speeds and damping coefficients on the coupled vibration response of the vehicle-track-overhead system. The findings demonstrate that the response of the train body is sensitive to track irregularity, which primarily impacts the safety index of train operation. The results also suggest that the level of track irregularity should be rigorously regulated above AAR5 during construction. The train-track-overhead system functions well and satisfies the overhead system’s design requirements when the train travels through the reinforced line at a speed of no more than 60 km/h. When the train speed is 100 km/h, the vertical acceleration exceeds the limit for the “I” overhead system. There is a possibility of excessive lateral acceleration of the train body and excessive lateral force of the wheel and rail when the train speed is greater than 60 km/h, which endangers the safety of the driver. While it has little effect on the mid-span and vertical displacements, the damping factor of the bridge has a substantial impact on the vertical acceleration and mid-span acceleration of the vertical and horizontal beams. The study’s findings provide useful guidance