CEO Overconfidence, CEO Power, and Corporate Performance

Under the modern enterprise system, with the separation of ownership and control, executives are responsible for the daily operation of the enterprise. The personal characteristics of executives affect their behavioral tendencies and then affect the business choice and development direction of the enterprise, thus affecting corporate performance. Overconfidence, as a prominent representative of the irrational characteristics of executives, has been widely concerned by scholars. From the perspective of corporate governance, this paper discusses the impact of CEO overconfidence on corporate performance and adds CEO power as a moderating variable to analyze the impact of CEO power on the relation between the two, providing a reference for the development and improvement of the corporate governance system. This paper selects the listed companies covered by the US S&P 500 index from 2016 to 2021 as the research object, uses the change of CEO shareholding to measure CEO overconfidence, measures corporate performance with ROA, and sets up the empirical models. This paper uses Stata to conduct empirical analysis and draws the following conclusions. First, CEO overconfidence is negatively correlated with corporate performance. Second, CEO power positively moderates the negative correlation between the two. Finally, according to the research conclusion, this paper puts forward some recommendations, explains the shortcomings of the research, and prospects for the future research direction

A novel hand-eye calibration method of picking robot based on TOF camera

Aiming at the stability of hand-eye calibration in fruit picking scene, a simple hand-eye calibration method for picking robot based on optimization combined with TOF (Time of Flight) camera is proposed. This method needs to fix the TOF depth camera at actual and calculated coordinates of the peach the end of the robot, operate the robot to take pictures of the calibration board from different poses, and record the current photographing poses to ensure that each group of pictures is clear and complete, so as to use the TOF depth camera to image the calibration board. Obtain multiple sets of calibration board depth maps and corresponding point cloud data, that is, “eye” data. Through the circle center extraction and positioning algorithm, the circle center points on each group of calibration plates are extracted, and a circle center sorting method based on the vector angle and the center of mass coordinates is designed to solve the circle center caused by factors such as mirror distortion, uneven illumination and different photographing poses. And through the tool center point of the actuator, the coordinate value of the circle center point on the four corners of each group of calibration plates in the robot end coordinate system is located in turn, and the “hand” data is obtained. Combined with the SVD method, And according to the obtained point residuals, the weight coefficients of the marker points are redistributed, and the hand-eye parameters are iteratively optimized, which improves the accuracy and stability of the hand-eye calibration. the method proposed in this paper has a better ability to locate the gross error under the environment of large gross errors. In order to verify the feasibility of the hand-eye calibration method, the indoor picking experiment was simulated, and the peaches were identified and positioned by combining deep learning and 3D vision to verify the proposed hand-eye calibration method. The JAKA six-axis robot and TuYang depth camera are used to build the experimental platform. The experimental results show that the method is simple to operate, has good stability, and the calibration plate is easy to manufacture and low in cost. work accuracy requirements

Ku80 cooperates with CBP to promote COX-2 expression and tumor growth.

Cyclooxygenase-2 (COX-2) plays an important role in lung cancer development and progression. Using streptavidin-agarose pulldown and proteomics assay, we identified and validated Ku80, a dimer of Ku participating in the repair of broken DNA double strands, as a new binding protein of the COX-2 gene promoter. Overexpression of Ku80 up-regulated COX-2 promoter activation and COX-2 expression in lung cancer cells. Silencing of Ku80 by siRNA down-regulated COX-2 expression and inhibited tumor cell growth in vitro and in a xenograft mouse model. Ku80 knockdown suppressed phosphorylation of ERK, resulting in an inactivation of the MAPK pathway. Moreover, CBP, a transcription co-activator, interacted with and acetylated Ku80 to co-regulate the activation of COX-2 promoter. Overexpression of CBP increased Ku80 acetylation, thereby promoting COX-2 expression and cell growth. Suppression of CBP by a CBP-specific inhibitor or siRNA inhibited COX-2 expression as well as tumor cell growth. Tissue microarray immunohistochemical analysis of lung adenocarcinomas revealed a strong positive correlation between levels of Ku80 and COX-2 and clinicopathologic variables. Overexpression of Ku80 was associated with poor prognosis in patients with lung cancers. We conclude that Ku80 promotes COX-2 expression and tumor growth and is a potential therapeutic target in lung cancer

CEO Overconfidence, CEO Power, and Corporate Performance

Under the modern enterprise system, with the separation of ownership and control, executives are responsible for the daily operation of the enterprise. The personal characteristics of executives affect their behavioral tendencies and then affect the business choice and development direction of the enterprise, thus affecting corporate performance. Overconfidence, as a prominent representative of the irrational characteristics of executives, has been widely concerned by scholars. From the perspective of corporate governance, this paper discusses the impact of CEO overconfidence on corporate performance and adds CEO power as a moderating variable to analyze the impact of CEO power on the relation between the two, providing a reference for the development and improvement of the corporate governance system. This paper selects the listed companies covered by the US S&P 500 index from 2016 to 2021 as the research object, uses the change of CEO shareholding to measure CEO overconfidence, measures corporate performance with ROA, and sets up the empirical models. This paper uses Stata to conduct empirical analysis and draws the following conclusions. First, CEO overconfidence is negatively correlated with corporate performance. Second, CEO power positively moderates the negative correlation between the two. Finally, according to the research conclusion, this paper puts forward some recommendations, explains the shortcomings of the research, and prospects for the future research direction

SOX9 Inhibits the Progression of Osteonecrosis of the Femoral Head via the Activation of the Wnt/Beta-Catenin Pathway

Background: In this study, we aimed to explore whether the SRY-box transcription factor 9 (SOX9) can play protective roles against the occurrence and development of osteonecrosis of the femoral head (ONFH) by regulating the proliferation, apoptosis, and osteogenic differentiation of human bone marrow stromal cells (hBMSCs) via the Wnt/β-catenin pathway. Methods: We used 1600 mg of glucocorticoid (GC) to induce hBMSCs to establish an ONFH cell model and performed various experiments. Reverse transcription-quantitative polymerase chain reaction and western blotting assays were used to determine the expression levels of SOX9 and osteoblast markers, such as the RUNX family transcription factor 2 (RUNX2), alkaline phosphatase (ALP), osterix, Wnt3a, and β-catenin. An ALP detection kit was used to measure the ALP activity. Flow cytometry and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays were performed to determine the cell viability. Results: GC treatment decreased the expression levels of RUNX2, ALP, and osterix, suppressed ALP activity, and inhibited SOX9 expression. SOX9 overexpression promoted GC-induced cell proliferation and decreased cell apoptosis. Additionally, hBMSCs were transfected with SOX9-small interfering RNA in GC treatment, and SOX9 knockdown was found to suppress the osteogenic differentiation of cells and decrease their viability. Conclusion: Our results revealed that SOX9 is related to the Wnt/β-catenin pathway in ONFH. Moreover, SOX9 participated in ONFH development by activating the Wnt/β-catenin pathway

Major effect of transcytosis on nano drug delivery to pancreatic cancer

We demonstrated that activated transcytosis is a major mechanism to complement the classic enhanced permeability and retention effect in pancreatic cancer. This was achieved by using an iRGD peptide that triggers transcytosis pathway at the tumor site. Co-administration of unconjugated iRGD substantially improved the effect of the chemotherapeutics delivering nanocarrier, and resulted in survival improvement in mice. Since the iRGD effect is commensurate with neuropilin-1 expression on tumor vasculature, it is necessary to contemplate a personalized approach to implement this technology

Major effect of transcytosis on nano drug delivery to pancreatic cancer

We demonstrated that activated transcytosis is a major mechanism to complement the classic enhanced permeability and retention effect in pancreatic cancer. This was achieved by using an iRGD peptide that triggers transcytosis pathway at the tumor site. Co-administration of unconjugated iRGD substantially improved the effect of the chemotherapeutics delivering nanocarrier, and resulted in survival improvement in mice. Since the iRGD effect is commensurate with neuropilin-1 expression on tumor vasculature, it is necessary to contemplate a personalized approach to implement this technology

Audio Denoising Coprocessor Based on RISC-V Custom Instruction Set Extension

As a typical active noise control algorithm, Filtered-x Least Mean Square (FxLMS) is widely used in the field of audio denoising. In this study, an audio denoising coprocessor based on Retrenched Injunction System Computer-V (RISC-V), a custom instruction set extension was designed and a software and hardware co-design was adopted; based on the traditional pure hardware implementation, the accelerator optimization design was carried out, and the accelerator was connected to the RISC-V core in the form of coprocessor. Meanwhile, the corresponding custom instructions were designed, the compiling environment was established, and the library function of coprocessor acceleration instructions was established by embedded inline assembly. Finally, the active noise control (ANC) system was built and tested based on Hbird E203-Core, and the test data were collected through an audio analyzer. The results showed that the audio denoising algorithm can be realized by combining a heterogeneous System on Chip (SoC) with a hardware accelerator, and the denoising effect was approximately 8 dB. The number of instructions consumed by testing custom instructions for specific operations was reduced by approximately 60%, and the operation acceleration effect was significant

Accurate Real-Time Laser Spot Locating Based on Template Correlation in Intersatellite Laser Communications

In intersatellite laser communications, the centroiding accuracy of a laser spot is crucial for maintaining steady communication links. However, the systematic error introduced by discrete sampling restricts further improvement of centroiding accuracy when choosing algorithms that are widely used in engineering. Additionally, the ultrahigh computational complexity and multiple-step iterations of the Gaussian fitting (GF) algorithm are unsuitable for real-time implementation, even though the algorithm can achieve the highest centroiding accuracy. In this study, we propose a laser spot centroiding algorithm based on template correlation to simultaneously satisfy the requirements of real-time performance and accuracy. The proposed algorithm evaluates the central location of a laser spot by obtaining the index of the maximum Pearson correlation coefficient (PCC). Simulations performed under different conditions reveal that the proposed algorithm is robust against the interference of background noise and the bad pixels. Moreover, experimental verification is performed based on the implementation on a Field-Programmable Gate Array (FPGA) in real-time, meanwhile its accuracy is on the same level as that of the GF algorithm and better than those of other widely-used algorithms. Therefore, the proposed algorithm is suitable for accurate real-time locating of laser spots in engineering applications of the intersatellite laser communications

Processable polyimide resins and their composites for long-term application at 300 ℃

A series of processable and high-temperature resistant polyimide resins terminated with 4-phenylethynyl phthalic anhydride were synthesized by PMR (for in situ polymerization of monomer reactants) using isopropyl alcohol as esterifying agent. The resin solution stored at room temperature for sixteen weeks has no solid precipitation, and the viscosity of the solution does not change significantly, which shows good storage stability at room temperature. The minimum melt viscosity of the imide oligomers is less than 300 Pa·s, which is suitable for compression moulding or autoclaved process. The cured polyimides exhibit extremely high glass transition temperatures (Tg) up to 462℃. The flexural strength and modulus of T300/PMR-PE-2 carbon fiber composite are 963 MPa and 53 GPa, respectively. The inter-laminar shear strength of the composite is 56 MPa. Moreover, the composite can maintain no lower than 66% of their room temperature mechanical properties at 300℃. After isothermal aging in air atmosphere for 500 h at 300℃, the mass loss of the composite is only 0.96%, meanwhile, the composite retention rate maintains 72% of its room temperature flexural strength and 98% of its room temperature inter-laminar shear strength, which demonstrates its excellent thermal-oxidative aging resistance