Notoginseng root enhances healing in imiquimod-induced psoriasis mice model via anti-inflammatory and antiproliferative properties

Purpose: To evaluate the beneficial effect of Panax notoginseng (PN) gel against imiquimod-induced psoriasis in a mice model.Methods: Psoriasis was induced by topical application of imiquimod cream (5 %) on the shaved skin of mice for 7 days. PN group received PN gel (1 %) twice a day with imiquimod cream (5 %) once a day for one week. The effect of PN gel was estimated by scoring skin thickness, scaling and erythema. Reverse transcription polymerase chain reaction (RT-PCR) was used for the determination of the expressions of inflammatory mediators in skin tissues of mice. Moreover, the severity of inflammation was determined by histopathological and immunohistochemical assessment of skin tissues.Results: The severity of inflammation and the expressions of inflammatory mediators were significantly reduced in PN gel-treated group, relative to the negative control group. Treatment with PN gel attenuated the histopathology of skin tissue in the imiquimod-induced psoriatic mice, and significantly decreased the level of intercellular adhesion molecule (ICAM-1), when compared to the negative control group.Conclusion: These results show that PN gel attenuates psoriasis in imiquimod-induced psoriasis mice model by decreasing skin inflammation. Thus, PN gel may be suitable for the management of psoriasis.Keywords: Psoriasis, Panax notoginseng, Inflammatory mediators, Imiquimod, Intercellular Adhesion Molecule-

Measurement of the Degree of Coordination in Regard to Carbon Emissions, Economic Development, and Environmental Protection in China

Driven by economic development, the dramatic increase in carbon emissions has led to global warming and a series of environmental problems. The question of how to ensure harmonized coordination between economic development, carbon emissions and environmental protection has become increasingly important. The conflicts between the use of energy and emission reductions in China have become more intense. It is an inevitable requirement for China’s sustainable development to promote a low-carbon circular economy and the simultaneous and coordinated development of carbon emissions, the economy and the environment. The present study took 30 provinces (municipalities and autonomous regions directly under the Central Government) as the research objects (Tibet, Hong Kong, Macau, and Taiwan are not included in the study due to the lack of relevant data), and applied quantitative analysis methods, such as three-stage data envelopment analysis (DEA) models, coupling coordination degree models and spatial analysis models, to construct a measurement index system. On the basis of the measurement of its carbon emission efficiency, the level of China’s coordination degree in regard to carbon emissions, economic development, and environmental protection at both spatial and temporal dimensions was analyzed comprehensively in order to reveal its temporal and spatial characteristics. The conclusions are as follows: (1) China’s overall carbon emission efficiency displayed a gradual upward trend, although the overall level was not that high. Therefore, there is still much scope for further improvement. (2) The level of China’s coordination degree in regard to carbon emissions, economic development, and environmental protection showed a steady yet rising trend. All provinces reached different levels of coordination development, and there was no province that displayed a disorderly declining trend. However, the number of provinces that reached or went beyond the intermediate level of coordination development was quite limited. (3) The level of China’s coordination degree in regard to carbon emissions, economic development, and environmental protection displayed obvious spatial aggregation patterns at the provincial level, showing an apparent spatial dependence and heterogeneity. Over time, the level of spatial aggregation patterns in regard to coordination degree tended to weaken. Overall, the values were high in the eastern region and low in the western region, decreasing from the eastern coastal zone towards the western inland zone, thus demonstrating a contrasting east-west spatial distribution pattern

C 60 modified single-walled carbon nanotubes

Abstract Single-walled carbon nanotubes (SWNTs) can react with C 60 through simple solid-phase mechanochemical reaction at room temperature under nitrogen atmosphere to produce C 60 modified SWNTs

Construire un générateur de scénarios économiques risque neutre

Random lasing in a lotus leaf, with a wide tunable spectrum from planar liquid waveguide gain channels is described. The lotus leaf shows multiple scattering from the micro-papilla and nanoscale coralloid tomentum on its surface. The Fraunhofer diffraction pattern demonstrates excellent coherence and directionality for our random laser. The emission spectrum wavelength can be tuned by changing the pump position due to the random distribution of the micro/nano-scale features on the lotus leaf. Potential applications of the random laser include probing micro/nano-scale structural alterations, optical biosensors on chips, and developing a multi-color random laser