Education and Dementia in the Context of the Cognitive Reserve Hypothesis: A Systematic Review with Meta-Analyses and Qualitative Analyses

<div><h3>Background</h3><p>Cognitive reserve (CR) or brain reserve capacity explains why individuals with higher IQ, education, or occupational attainment have lower risks of developing dementia, Alzheimer’s disease (AD) or vascular dementia (VaD). The CR hypothesis postulates that CR reduces the prevalence and incidence of AD or VaD. It also hypothesizes that among those who have greater initial cognitive reserve (in contrast to those with less reserve) greater brain pathology occurs before the clinical symptoms of disease becomes manifest. Thus clinical disease onset triggers a faster decline in cognition and function, and increased mortality among those with initial greater cognitive reserve. Disease progression follows distinctly separate pathological and clinical paths. With education as a proxy we use meta-analyses and qualitative analyses to review the evidence for the CR hypothesis.</p> <h3>Methodology/Principal Findings</h3><p>We searched PubMed, PsycoINFO, EMBASE, HealthStar, and Scopus databases from January 1980 to June 2011 for observational studies with clear criteria for dementia, AD or VaD and education. One hundred and thirty-three articles with a variety of study designs met the inclusion criteria. Prevalence and incidence studies with odds ratios (ORs), relative risks or original data were included in the meta-analyses. Other studies were reviewed qualitatively. The studies covered 437,477 subjects. Prevalence and incidence studies with pooled ORs of 2.61 (95%CI 2.21–3.07) and 1.88 (95%CI 1.51–2.34) respectively, showed low education increased the risk of dementia. Heterogeneity and sensitivity tests confirmed the evidence. Generally, study characteristics had no effect on conclusions. Qualitative analyses also showed the protective effects of higher education on developing dementia and with clinical disease onset hastening a decline in cognition and function, and greater brain pathology.</p> <h3>Conclusion/Significance</h3><p>This systematic review and meta-analyses covering a wide range of observational studies and diverse settings provides robust support for the CR hypothesis. The CR hypothesis suggests several avenues for dementia prevention.</p> </div

Quantum phase transitional patterns in the SD-pair shell model

Patterns of shape-phase transition in the proton-neutron coupled systems are studied within the $SD$-pair shell model. The results show that some transitional patterns in the $SD$-pair shell model are similar to the $U(5)-SU(3)$, $U(5)-SO(6)$ transitions with signatures of the critical point symmetry of the interacting boson model.Comment: 13 pages, 7 figure

Study of QCD critical point using canonical ensemble method

The existence of the QCD critical point at non-zero baryon density is not only of great interest for experimental physics but also a challenge for the theory. We use lattice simulations based on the canonical ensemble method to explore the finite baryon density region and look for the critical point. We scan the phase diagram of QCD with three degenerate quark flavors using clover fermions with $m_\pi \approx 700{MeV}$ on $6^3\times4$ lattices. We measure the baryon chemical potential as we increase the density and we see the characteristic "S-shape" that signals the first order phase transition. We determine the phase boundary by Maxwell construction and report our preliminary results for the location of critical point.Comment: 2 pages, 2 figures - To appear in the conference proceedings for Quark Matter 2009, March 30 - April 4, Knoxville, Tennesse

Finite density phase transition of QCD with Nf=4N_f=4 and Nf=2N_f=2 using canonical ensemble method

In a progress toward searching for the QCD critical point, we study the finite density phase transition of $N_f = 4$ and 2 lattice QCD at finite temperature with the canonical ensemble approach. We develop a winding number expansion method to accurately project out the particle number from the fermion determinant which greatly extends the applicable range of baryon number sectors to make the study feasible. Our lattice simulation was carried out with the clover fermions and improved gauge action. For a given temperature, we calculate the baryon chemical potential from the canonical approach to look for the mixed phase as a signal for the first order phase transition. In the case of $N_f=4$, we observe an "S-shape" structure in the chemical potential-density plane due to the surface tension of the mixed phase in a finite volume which is a signal for the first order phase transition. We use the Maxwell construction to determine the phase boundaries for three temperatures below $T_c$. The intersecting point of the two extrapolated boundaries turns out to be at the expected first order transition point at $T_c$ with $\mu = 0$. This serves as a check for our method of identifying the critical point. We also studied the $N_f =2$ case, but do not see a signal of the mixed phase for temperature as low as 0.83 $T_c$.Comment: 28 pages, 11 figures,references added, final versio

Electroconvulsive therapy for agitation in schizophrenia: Meta-analysis of randomized controlled trials

Background: Agitation poses a significant challenge in the treatment of schizophrenia. Electroconvulsive therapy (ECT) is a fast, effective and safe treatment for a variety of psychiatric disorders, but no meta-analysis of ECT treatment for agitation in schizophrenia has yet been reported. Aims: To systematically evaluate the efficacy and safety of ECT alone or ECT-antipsychotics (APs) combination for agitation in schizophrenia. Methods: Systematic literature search of randomized controlled trials (RCTs) was performed. Two independent evaluators selected studies, extracted data about outcomes and safety with available data, conducted quality assessment and data synthesis. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) was used to judge the level of the overall evidence of main outcomes. Results: Seven RCTs from China, including ECT alone (4 RCTs with 5 treatment arms, n=240) and ECT-APs combination (3 RCTs, n=240), were identified. Participants in the studies were on average 34.3(4.5) years of age and lasted an average of 4.3(3.1) weeks of treatment duration. All 7 RCTs were non-blinded, and were rated as low quality based on Jadad scale. Meta-analysis of the pooled sample found no significant difference in the improvement of the agitation sub-score of the Positive and Negative Syndrome Scale (PANSS) when ECT alone (weighted mean difference=-0.90, (95% confidence interval (CI): -2.91, 1.11), p=0.38) or ECT-APs combination (WMD=-1.34, (95%CI: -4.07, 1.39), p=0.33) compared with APs monotherapy. However, ECT alone was superior to APs monotherapy regarding PANSS total score (WMD=-7.13, I2=0%, p=0.004) and its excitement sub-score (WMD=-1.97, pI2=0%, p=0.004) and its excitement sub-score at 7 and 14 days (WMD=-1.97 to -1.92, p=0.002 to 0.0001) after ECT. The ECT-APs combination was superior to APs monotherapy with respect to the PANSS total score at treatment endpoint (WMD=-10.40, p=0.03) and 7 days (WMD=-5.01, p=0.02). Headache ( number-needed-to-harm (NNH)=3, 95%CI=2-4) was more frequent in the ECT alone group compared to AP monotherapy. According to the GRADE approach, the evidence levels of main outcomes were rated as ‘‘very low’’ (37.5%) and “low” (50%). Conclusion: Pooling of the data based on 7 RCTs from China found no advantage of ECT alone or ECT-APs combination in the treatment of agitation related outcomes in schizophrenia patients. However, ECT alone or ECT-APs combination were associated with significant reduction in the PANSS total score. High-quality RCTs are needed to confirm the current interpretations. Review registration number: CRD4201400668

Optimization of long cycle emission reduction paths for new-type power system considering electric-thermal coupling

The carbon factor is the core driving force behind the low-carbon transformation of the power system. The study of Emission Reduction Paths (ERPs) has become a key issue for the New-type Power System to achieve clean and low-carbon goals. In order to measure the relationship between ERP and the economy, this paper considers the retirement requirements of coal-fired power units and emission reduction requirements on a long cycle planning scale, and constructs a multi-scenario planning model that considers electric-thermal coupling, enabling the determination of installed capacity for power and heat sources each year. The effectiveness of the proposed model was verified using an improved IEEE-39 bus power system. A case study was conducted to analyze the economic performance of the system based on the selected ERP set. The results showed that under the rear acceleration’s ERP, the system could achieve optimal economic performance based on the selected ERP set

Quantifying the Impact of Next-Generation Modes of Delivery

Project Name: Quantifying the Impact of Next Generation Modes of DeliveryIn the last two years, a new delivery paradigm has emerged for transporting goods on the socalled last mile to households, pioneered by such services as Google Shopping Express, Amazon Prime, Instacart, and Walmart To Go, among many others. Such services reduce the need for households to travel because one can simply order products online and have them delivered quickly to one\u2019s doorstep. However, it is not yet understood (or, more specifically, quantified) to what degree such services result in social benefits vis-a-vis congestion and carbon emissions