88 research outputs found

    Two new species of Bisetocreagris Ćurčić, 1983 (Pseudoscorpiones: Neobisiidae) from China

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    Two new Bisetocreagris species belonging to the family Neobisiidae are described from China: Bisetocreagris yangae sp. n. from Anhui Province and Bisetocreagris parva sp. n. from Zhejiang Province. Detailed diagnoses, descriptions and illustrations of the two new species are presented

    Evaluation of Plasma Extracellular Vesicle MicroRNA Signatures for Lung Adenocarcinoma and Granuloma With Monte-Carlo Feature Selection Method

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    Extracellular Vesicle (EV) is a compilation of secreted vesicles, including micro vesicles, large oncosomes, and exosomes. It can be used in non-invasive diagnosis. MicroRNAs (miRNAs) processed by exosomes can be detected by liquid biopsy. To objectively evaluate the discriminative ability of miRNAs from whole plasma, EV and EV-free plasma, we analyzed the miRNA expression profiles in whole plasma, EV and EV-free plasma of 10 lung adenocarcinoma and 9 granuloma patients. With Monte-Carlo feature selection method, the top discriminative miRNAs in whole plasma, EV and EV-free plasma were identified, and they were quite different. Using the Repeated Incremental Pruning to Produce Error Reduction (RIPPER) method, we learned the classification rules: in whole plasma, granuloma patients did not express hsa-miR-223-3p while the lung adenocarcinoma patients expressed hsa-miR-223-3p; in EV, the hsa-miR-23b-3p was highly expressed in granuloma patients but not lung adenocarcinoma patients; in EV-free plasma, hsa-miR-376a-3p was expressed in granuloma patients but barely expressed in lung adenocarcinoma patients. For prediction performance, whole plasma had the highest weighted accuracy and EV outperformed EV-free plasma. Our results suggested that EV can be used as lung cancer biomarker. However, since it is less stable and not easy to detect, there are still technological difficulties to overcome

    Description of three new Bisetocreagris species (Pseudoscorpiones: Neobisiidae) from Southern China

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    Three new Bisetocreagris species are described from southern China: Bisetocreagris shunhuangensis sp. n. from Hunan Province, B. wangi sp. n. and B. gaoi sp. n. from Guizhou Province. Detailed diagnoses, descriptions and illustrations of the three new species are presented
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