Protein Evolution in Yeast Transcription Factor Subnetworks

When averaged over the full yeast protein–protein interaction and transcriptional regulatory networks, protein hubs with many interaction partners or regulators tend to evolve significantly more slowly due to increased negative selection. However, genome-wide analysis of protein evolution in the subnetworks of associations involving yeast transcription factors (TFs) reveals that TF hubs do not tend to evolve significantly more slowly than TF non-hubs. This result holds for all four major types of TF hubs: interaction hubs, regulatory in-degree and out-degree hubs, as well as co-regulatory hubs that jointly regulate target genes with many TFs. Furthermore, TF regulatory in-degree hubs tend to evolve significantly more quickly than TF non-hubs. Most importantly, the correlations between evolutionary rate (KA/KS) and degrees for TFs are significantly more positive than those for generic proteins within the same global protein–protein interaction and transcriptional regulatory networks. Compared to generic protein hubs, TF hubs operate at a higher level in the hierarchical structure of cellular networks, and hence experience additional evolutionary forces (relaxed negative selection or positive selection through network rewiring). The striking difference between the evolution of TF hubs and generic protein hubs demonstrates that components within the same global network can be governed by distinct organizational and evolutionary principles.National Natural Science Foundation of China (10801131, 10631070); National Science Foundation (DGE-0654108); Pharmaceutical Research and Manufacturers of America Foundation (Research Starter Grant in Informatics); K. C. Wong Education Foundatio

Tentative evidence of spatially extended GeV emission from SS433/W50

We analyze 10 years of Fermi-LAT data towards the SS433/W50 region. With the latest source catalog and diffuse background models, the gamma-ray excess from SS433/W50 is detected with a significance of 6{\sigma} in the photon energy range of 500 MeV - 10 GeV. Our analysis indicates that an extended flat disk morphology is preferred over a point-source description, suggesting that the GeV emission region is much larger than that of the TeV emission detected by HAWC. The size of the GeV emission is instead consistent with the extent of the radio nebula W50, a supernova remnant being distorted by the jets, so we suggest that the GeV emission may originate from this supernova remnant. The spectral result of the GeV emission is also consistent with an supernova remnant origin. We also derive the GeV flux upper limits on the TeV emission region, which put moderate constrains on the leptonic models to explain the multiwavelength data.Comment: 7 pages, 4 figures, accepted for publication in A&