Monitoring and analysis of blasting vibration in tunnel excavation of nuclear power plant

Vibration monitoring of blasting excavation of drainage tunnel in Lufeng Nuclear Power Plant is carried out and the data of blasting vibration is analyzed in this paper. The results show that: (1) The vertical vibration velocity of the rock mass is greater than the horizontal radial and horizontal tangential vibration velocity (2) The blasting vibration velocity of rock mass decreases with distance, which is affected by rock structure and explosive quantity. The monitoring research in this paper has guiding significance for vibration prediction and control in tunnel blasting excavation

Anti-obesity effect of an isoflavone fatty acid ester on obese mice induced by high fat diet and its potential mechanism

<p>Abstract</p> <p>Background</p> <p>The novel compound <b>1a </b>is one of the isoflavone fatty acid esters. In order to investigate the anti-obesity effect of compound <b>1a </b>and its potential mechanism of influence in adipocyte differentiation, Obese male C57BL/6J mice induced by high-fat diet (HFD) and rat preadipocytes (3T3-L1 cell) were used.</p> <p>Methods</p> <p>After 4-week HFD induction, the obese model was made successfully. After treatment with compound <b>1a</b>, mice plasma biochemistry parameters were analyzed. In addition, mice hepatic tissue slice was observed. In <it>in vitro </it>research, 3T3-L1 cell differentiation by Oil-Red-O staining and adipocyte apoptosis was detected by flow cytometry.</p> <p>Results</p> <p>The <it>in vivo </it>results implied that compound <b>1a </b>significantly decreased the body weight, white adipose tissue weight of obesity mice(p < 0.05), reduced leptin and TG in plasma(p < 0.05), elevated HDL-C in serum(p < 0.05). The <it>in vitro </it>results suggested that compound <b>1a </b>could significantly suppress the adipocyte viability and lipid accumulation in the differentiation of preadipocyte, and induce apoptosis in both preadipocytes and mature adipocytes(p < 0.05).</p> <p>Conclusion</p> <p>Compound <b>1a </b>regulates serum lipid profiles, decreases adipose tissue mass and body weight gain by inducing adipocyte apoptosis in high fat diet induced mice. Thus, it may be used to treat obese patients with hypercholesterolemia and hypertriglyceridemia.</p

1H-Pyrrole-2-carboxylic acid

In the title compound, C5H5NO2, the pyrrole ring and its carboxyl substituent are close to coplanar, with a dihedral angle of 11.7 (3)° between the planes. In the crystal structure, adjacent mol­ecules are linked by pairs of O—H⋯O hydrogen bonds to form inversion dimers. Additional N—H⋯O hydrogen bonds link these dimers into chains extending along the a axis

1-Ethyl-1H,6H-pyrrolo[2,3-c]azepine-4,8(5H,7H)-dione

The title compound, C10H12N2O2, was synthesized by cyclization of 3-(1-ethyl­pyrrole-2-carboxamido)propanoic acid in the presence of polyphospho­ric acid and diphospho­rus pentoxide. In the crystal structure, adjacent mol­ecules are linked by N—H⋯O hydrogen bonds, forming chains extending along the b axis

Methyl 3-[(1-butyl-1H-indol-3-yl)carbonyl­amino]propionate

In the title mol­ecule, C17H22N2O3, the mean plane of the terminal (C=O)OMe fragment and the indole plane form a dihedral angle of 78.94 (3)°. Inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into chains extended along the c axis. The crystal packing exhibits π–π inter­actions, indicated by the short distance of 3.472 (2) Å between the centroids of the five-membered heterocycles of neighbouring mol­ecules

Methyl (1H-pyrrol-2-ylcarbonyl­amino)acetate

In the crystal structure of the title compound, C8H10N2O3, mol­ecules are linked by N—H⋯O hydrogen bonds, forming ribbons of centrosymmetric dimers extending along the c axis

The Holistic Effects of Acupuncture Treatment

Traditional Chinese Medicine (TCM), as a complex medical science which reflects philosophical principles and embodies large dialectical thought, is used to place the human body into a large system for observation. Acupuncture as a vital part of TCM, has been practiced to treat various diseases and symptoms. However, acupuncture is also facing severe challenges resulted from insufficient modern scientific research. Nowadays, the holistic effects of acupuncture can be researched by some modern approaches, such as the systems biology and fMRI technique. It is believed that having a better understand will greatly promote acupuncture research and be beneficial to scientization and modernization of acupuncture

The development and evaluation of individualized templates to assist transoral C2 articular mass or transpedicular screw placement in TARP-IV procedures: adult cadaver specimen study

OBJECTIVES: The transoral atlantoaxial reduction plate system treats irreducible atlantoaxial dislocation from transoral atlantoaxial reduction plate-I to transoral atlantoaxial reduction plate-III. However, this system has demonstrated problems associated with screw loosening, atlantoaxial fixation and concealed or manifest neurovascular injuries. This study sought to design a set of individualized templates to improve the accuracy of anterior C2 screw placement in the transoral atlantoaxial reduction plate-IV procedure. METHODS: A set of individualized templates was designed according to thin-slice computed tomography data obtained from 10 human cadavers. The templates contained cubic modules and drill guides to facilitate transoral atlantoaxial reduction plate positioning and anterior C2 screw placement. We performed 2 stages of cadaveric experiments with 2 cadavers in stage one and 8 in stage two. Finally, guided C2 screw placement was evaluated by reading postoperative computed tomography images and comparing the planned and inserted screw trajectories. RESULTS: There were two cortical breaching screws in stage one and three in stage two, but only the cortical breaching screws in stage one were ranked critical. In stage two, the planned entry points and the transverse angles of the anterior C2 screws could be simulated, whereas the declination angles could not be simulated due to intraoperative blockage of the drill bit and screwdriver by the upper teeth. CONCLUSIONS: It was feasible to use individualized templates to guide transoral C2 screw placement. Thus, these drill templates combined with transoral atlantoaxial reduction plate-IV, may improve the accuracy of transoral C2 screw placement and reduce related neurovascular complications