An Inconspicuous Six-Coordinate Neutral Dy-III Single-Ion Magnet with Remarkable Magnetic Anisotropy and Stability

10.1021/acs.inorgchem.0c00616INORGANIC CHEMISTRY59107158-716

Establishment and validation of a predictive nomogram model for non-small cell lung cancer patients with chronic hepatitis B viral infection

Abstract Background This study aimed to establish an effective predictive nomogram for non-small cell lung cancer (NSCLC) patients with chronic hepatitis B viral (HBV) infection. Methods The nomogram was based on a retrospective study of 230 NSCLC patients with chronic HBV infection. The predictive accuracy and discriminative ability of the nomogram were determined by a concordance index (C-index), calibration plot and decision curve analysis and were compared with the current tumor, node, and metastasis (TNM) staging system. Results Independent factors derived from Kaplan–Meier analysis of the primary cohort to predict overall survival (OS) were all assembled into a Cox proportional hazards regression model to build the nomogram model. The final model included age, tumor size, TNM stage, treatment, apolipoprotein A-I, apolipoprotein B, glutamyl transpeptidase and lactate dehydrogenase. The calibration curve for the probability of OS showed that the nomogram-based predictions were in good agreement with the actual observations. The C-index of the model for predicting OS had a superior discrimination power compared with the TNM staging system [0.780 (95% CI 0.733–0.827) vs. 0.693 (95% CI 0.640–0.746), P  20.0). Conclusion The proposed nomogram model resulted in more accurate prognostic prediction for NSCLC patients with chronic HBV infection

Bromine-bridged Dy2 single-molecule magnet: magnetic anisotropy driven by cis/trans stereoisomers

International audienceWe report the first bromine-bridged dinuclear [Dy(CyPO)(μ-Br)(Br)]·2CH single-molecule magnet with an effective energy barrier of 684 K and magnetic hysteresis below 3 K. The asymmetric Dy centres present two unique stereoisomeric octahedral coordination environments depending on the cis/trans disposition of the CyPO ligands, leading to the orthogonality of the easy magnetic axes that annihilates the dipolar interactions

High temperature quantum tunnelling of magnetization and thousand kelvin anisotropy barrier in a Dy(2) single-molecule magnet

International audienceWe report here a dinuclear DyIII iodine-bridged single-molecule magnet self-assembled by cis/trans coordination chemistry that displays a large anisotropy barrier of ca. 1300 K and a hysteresis opening temperature of 16 K. High temperature quantum tunnelling of magnetization is observed up to 56 K in zero-field and explained by the combination of the large anisotropy barrier and the local transverse field at the trans site. The results provide a model for thorough understanding of the effect of electronic structure on the magnetic behavior of lanthanide complexes

Charge redistribution enhanced oxygen reduction of carbon-based electrocatalyst

The surface charge distribution is regarded as a key factor affecting the electrocatalytic performance. Herein, we report a strategy to regulate the surface charge distribution in carbon-based electrocatalyst to enhance its activity and stability in oxygen reduction reaction (ORR). The sample obtained in a sealed reactor N,S co-doped carbon encapsulate Co9S8 nanoparticles (Co9S8@CNS-S) exhibits excellent ORR performance. X-ray photoelectron spectroscopy, kelvin probe force microscopy and density functional theory simulation were used to investigate the mechanism of performance improvement. The enhanced ORR activity was due to the exposed more positive charge of surface carbon atoms by N, S elements doping synergistic with Co9S8 nanoparticles (NPs). The improved ORR stability was attributed to the carbon layer combination with Co9S8 NPs which greatly suppresses the generation of H2O2, thus avoiding the erosion of H2O2 on carbon layer during electrocatalysis. This work provides a strategy to regulate electrocatalyst surface charge distribution to achieve active and stable ORR electrocatalyst.The financial support from the National Natural Science Foundation of China (No. 22173072, 21676216, 21973074, 22273073), Innovation Capability Support Program of Shaanxi Province (No. 2022TD-32) and Preferential Funding Project for Scientific and Technological Activities of Overseas Chinese in Shaanxi Province (No. 2021008) are gratefully acknowledged

NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

BRCA1 mutation carriers have higher chances of developing triple-negative breast cancer (TNBC). Here, the authors use the Sleeping Beauty mutagenesis system in Brca1 deficient mice and identify 169 putative driver genes, of which NOTCH1 accelerates TNBC formation through promoting epithelial-mesenchymal transition and cell cycle progression