Topological edge state transfer via topological adiabatic passage

The study of quantum state transfer has led to a variety of research efforts utilizing quantum simulators. By exploiting the tunability of the qubit frequency and qubit-qubit coupling, a superconducting qubit chain can simulate various topological band models. In our study, we demonstrate that a spin-up state can be transported along a topological qubit chain by modulating the coupling strengths and the qubit frequencies. We here propose another more straightforward approach to theoretically interpret this state transfer process. We show that the Hilebert space of the qubit chain can be restricted into the subspace of the only two edge states when investigating this process, and the Hamiltonian can degenerate to a two-state Landau-Zener (LZ) model. Therefore the state transfer process in this topological qubit chain is equivalent to the same process through the adiabatic passage of the LZ model. Further more, we show how to use this approach to generalize the state transfer process from one-qubit Fock state to two-qubit Bell state.Comment: arXiv admin note: substantial text overlap with arXiv:1711.0682

A Simple and Effective Baseline for Attentional Generative Adversarial Networks

Synthesising a text-to-image model of high-quality images by guiding the generative model through the Text description is an innovative and challenging task. In recent years, AttnGAN based on the Attention mechanism to guide GAN training has been proposed, SD-GAN, which adopts a self-distillation technique to improve the performance of the generator and the quality of image generation, and Stack-GAN++, which gradually improves the details and quality of the image by stacking multiple generators and discriminators. However, this series of improvements to GAN all have redundancy to a certain extent, which affects the generation performance and complexity to a certain extent. We use the popular simple and effective idea (1) to remove redundancy structure and improve the backbone network of AttnGAN. (2) to integrate and reconstruct multiple losses of DAMSM. Our improvements have significantly improved the model size and training efficiency while ensuring that the model's performance is unchanged and finally proposed our \textbf{SEAttnGAN}. Code is avalilable at https://github.com/jmyissb/SEAttnGAN.Comment: 12 pages, 3 figure

Efficacy and safety of bempedoic acid for prevention of cardiovascular events and diabetes: a systematic review and meta-analysis.

BACKGROUND: Bempedoic acid is an oral, once-daily, first-in-class drug being developed for the treatment of hyperlipidemia. However, evidence of bempedoic acid use for the prevention of cardiovascular events and diabetes is lacking. Thus, we aim to evaluate the benefit and safety of bempedoic acid use for the prevention of cardiovascular events and diabetes. METHODS: We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials with no language restriction from inception until March 3, 2020. Pairs of reviewers independently identified randomized controlled trials comparing the use of bempedoic acid with placebo or no treatment for primary prevention of cardiovascular events in statin-intolerant patients with hypercholesterolemia. The primary outcomes were major adverse cardiac events, and percent change in LDL-C. RESULTS: We identified 11 trials including a total of 4391 participants. Bempedoic acid use was associated with a reduction in composite cardiovascular outcome (RR 0.75, 95% CI 0.56-0.99; I CONCLUSIONS: Bempedoic acid in patients with hypercholesterolemia was associated with a lower risk of cardiovascular events and diabetes

Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion

AbstractThousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p. In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competing endogenous RNAs to affect the function of Claudin-4. Our results suggest that non-coding RNAs play important roles in the regulatory network of Claudin-4. As such, non-coding RNAs should be considered as potential biomarkers and therapeutic targets against gastric cancer.</jats:p

On the Linkage between the Extreme Drought and Pluvial Patterns in China and the Large-Scale Atmospheric Circulation

China is a nation that is affected by a multitude of natural disasters, including droughts and floods. In this paper, the variations of extreme drought and pluvial patterns and their relations to the large-scale atmospheric circulation have been analyzed based on monthly precipitation data from 483 stations during the period 1958–2010 in China. The results show the following: (1) the extreme drought and pluvial events in China increase significantly during that period. During 1959–1966 timeframe, more droughts occur in South China and more pluvial events are found in North China (DSC-PNC pattern); as for the period 1997–2003 (PSC-DNC pattern), the situation is the opposite. (2) There are good relationships among the extreme drought and pluvial events and the Western Pacific Subtropical High, meridional atmospheric moisture flux, atmospheric moisture content, and summer precipitation. (3) A cyclone atmospheric circulation anomaly occurs in North China, followed by an obvious negative height anomaly and a southern wind anomaly at 850 hPa and 500 hPa for the DSC-PNC pattern during the summer, and a massive ascending airflow from South China extends to North China at ~50∘N. As for the PSC-DNC pattern, the situation contrasts sharply with the DSC-PNC pattern

Which is better for gastric cancer patients, perioperative or adjuvant chemotherapy: a meta-analysis

meta-analysis of chemotherapy adverse effects. (A) Nausea and vomit, (B) gastrointestinal problem, (C) liver toxicity, (D) neurologic effects, (E) leukopenia, (F) thrombocytopenia, (G) neutropenia. (TIF 507 kb

Kinetic Analysis of Bio-Oil Aging by Using Pattern Search Method

Bio-oil derived from fast pyrolysis of lignocellulosic biomass is unstable, and aging would occur during its storage, handling, and transportation. The kinetic analysis of bio-oil aging is fundamental for the investigation of bio-oil aging mechanisms and the utilization of bio-oil as biofuels, biomaterials or biochemicals. The aging kinetic experiments of bio-oil from poplar wood pyrolysis were conducted at different aging temperatures of 303, 333, 353, and 363 K for different specified periods of time in capped glass vessels. The traditional method with two separate fittings was employed to fit experimental data, and the results indicated that the obtained kinetic parameters could not fit the experimental data well. An advanced approach for kinetic modeling of bio-oil aging has been developed by simultaneously processing experimental data at different aging temperatures and using the pattern search method. The aging kinetic model with the optimized parameters predicted the aging kinetic experimental data of the bio-oil sample very well for different aging temperatures

Evaluation of TRMM Multisatellite Precipitation Analysis in the Yangtze River Basin with a Typical Monsoon Climate

Satellite-based precipitation products are expected to offer an alternative to ground-based rainfall estimates in the present and the foreseeable future. In this paper, we evaluate the performance of TRMM 3B42 precipitation products in the Yangtze River basin for the period of 2003~2010. The results are as follows: (1) the performance of RTV7 (V7) products is generally better than that of RTV6 (V6) in the Yangtze River basin, and the percentage of best performance (bias ranging within −10%~10%) for the annual mean precipitation increases from 21.72% (54.79%) to 36.70% (59.85%) as the RTV6 (V6) improved to the RTV7 (V7); (2) the TMPA products have better performance in the wet period than that in the dry period in the Yangtze River basin; (3) the performance of TMPA precipitation has been affected by the elevation and a downward trend can be found with the increasing elevation in the Yangtze River basin. The average CC between the V7 and observed precipitation in July decreases from 0.71 to 0.40 with the elevation of gauge stations increasing from 500 m below to 4000 m above in the Yangtze River basin. More attention should be paid to the influence of complex climate and topography

Association between Vitamin D supplementation and mortality in critically ill patients: A systematic review and meta-analysis of randomized clinical trials.

BACKGROUND: Observational studies suggest that low 25-hydroxyvitamin D status is common and has been associated with higher mortality in critically ill patients. This study aim to investigate whether vitamin D supplementation is associated with lower mortality in critically ill patients. METHOD: We searched Medline, Embase, and Cochrane databases from inception to January 12, 2020, without language restrictions, for randomized controlled trials comparing the effect of vitamin D supplementation with placebo in critically ill patients. Two authors independently performed data extraction and assessed study quality. The primary outcome was all-cause mortality at the longest follow-up. RESULT: We identified nine trials with a total of 2066 patients. Vitamin D supplementation was not associated with reduced all-cause mortality at the longest follow-up (RR 0.90, 95% CI 0.74 to 1.09, I2 = 20%), at 30 days (RR 0.81, 95% CI 0.56 to 1.15), at 90 days (RR 1.15, 95% CI 0.92 to 1.44), and at 180 days (RR 0.82, 95% CI 0.65 to 1.03). Results were similar in the sensitivity analysis. The sample size met the optimum size in trial sequential analysis. Similarly, supplemental vitamin D was not associated with length of ICU stay, hospital stay, or mechanical ventilation. CONCLUSION: Vitamin D supplement was not associated with reduced all-cause mortality in critically ill patients. SYSTEMATIC REVIEW REGISTRATION: Open Science Framework https://osf.io/bgsjq