A efetividade da Ivermectina® na atenuação de vírus de RNA: uma alternativa para enfrentar o SARS-CoV-2 / The effectiveness of Ivermectin® in mitigating the RNA virus: an alternative to attack SARS-CoV-2

A organização Mundial de Saúde (OMS) declarou, em março de 2020, um quadro pandêmico causado pela rápida disseminação e proliferação do agente infeccioso conhecido como SARS-CoV-2. Mais de seis milhões de pessoas em todos os continentes foram infectadas, e apesar dos esforços da comunidade científica, segue incerto quais fármacos possuem melhor efeito no controle e prognostico do COVID-19. Desta forma, essa pesquisa caracterizada como uma revisão integrativa, descritiva, transversal, buscou investigar a efetividade da Ivermectina® em vírus de RNA, e seu possível uso no enfrentamento ao SARS-CoV-2. As plataformas PubMed e BVS foram as que forneceram dados que compuseram a amostra. Filtros de periodização e critérios de inclusão e exclusão delimitaram o escopo do estudo. Aplicado os filtros e feita a coleta de dados, dez artigos demonstraram capacidade de responder as perguntas propostas. A Ivermectina® demonstrou eficácia antiviral no combate a vírus de RNA e SARS-CoV-2. No entanto, permanece incerto a dosagem e periodização para uso da mesma. Se faz necessário uma rápida disseminação de estudo clínicos e publicações científicas no que concerne a esse parâmetro

The impact of the COVID-19 pandemic in Brazil: a study in tertiary dental care

Abstract The pandemic caused by coronavirus has resonated throughout different levels of health care in Brazil and, in this context, the present research aimed to evaluate this impact on tertiary dental care provided by the Unified Health System (SUS). Therefore, an ecological study was conducted with data obtained from the Hospital Information System processed by the Portal of the Department of Informatics of SUS. The sample consisted of patients of all sexes and age groups, whose Hospital Admission Authorizations (AIHs) were approved for dental tertiary care procedures from January 2015 to December 2020. Descriptive analyses and the ANOVA test with a significance level set at p < 0.05 were used. When the annual mean numbers of AIHs approved were evaluated, findings showed that on an average, the Southeast region authorized a higher number of procedures (p-value < 0.001), however, in the pandemic year (2020), a reduction of approximately 24.5% of these hospitalizations occurred throughout Brazil, with the Midwest being the region most affected (32.12%). A percentage increase occurred in the Surgical Treatment of Oral sinus/Oral nasal Fistula (16.1%), in addition to a significant decrease in performing procedures for Resection of Mouth Lesion (33.4%). In the pandemic year, there was a reduction of 14% in expenditures related to hospital services and 23.26% related to professional services. It was concluded that the data presented demonstrated a significant reduction in AIHs for tertiary dental care in the pandemic year

Physicochemical characterization of a new raw material obtained from leaves of Syzygium cumini (L.) Skeel (Myrtaceae)

The aim of this study was to determine the physicochemical characteristics of leaves of Syzygium cumini L. Skeels plant and characterize the extract of this plant by analytical techniques. Pharmacopeial methods of physicochemical analysis were used, including morphological characterization of the particle, thermal analysis, infrared spectroscopy and X-ray diffraction. The plant drug was presented as a coarse powder, within the appropriate Brazilian Pharmacopoeia parameters. The X-ray diffraction, optical microscopy and scanning electron microscopy suggested that the extract particles are amorphous and have irregular shapes, so that clusters of different sizes and morphologies are displayed. Thermal decomposition of the organic components in the sample started in a step that occurred between 151.64 and 209.27 A degrees C with mass loss of 9.08 %, followed by another step with more significant mass loss (28.16 %). The infrared spectrum, in turn, showed many functional groups of compounds present in the lyophilized extract in different absorption bands. The results showed that the analytical techniques allowed us to characterize the physicochemical properties of the plant leaves, which may be useful in the production of new herbal medicines.The aim of this study was to determine the physicochemical characteristics of leaves of Syzygium cumini L. Skeels plant and characterize the extract of this plant by analytical techniques. Pharmacopeial methods of physicochemical analysis were used, including morphological characterization of the particle, thermal analysis, infrared spectroscopy and X-ray diffraction. The plant drug was presented as a coarse powder, within the appropriate Brazilian Pharmacopoeia parameters. The X-ray diffraction, optical microscopy and scanning electron microscopy suggested that the extract particles are amorphous and have irregular shapes, so that clusters of different sizes and morphologies are displayed. Thermal decomposition of the organic components in the sample started in a step that occurred between 151.64 and 209.27 A degrees C with mass loss of 9.08 %, followed by another step with more significant mass loss (28.16 %). The infrared spectrum, in turn, showed many functional groups of compounds present in the lyophilized extract in different absorption bands. The results showed that the analytical techniques allowed us to characterize the physicochemical properties of the plant leaves, which may be useful in the production of new herbal medicines12721137114