Análise volumétrica do soma neuronal na amígdala medial póstero-ventral de ratos machos e fêmeas em diferentes fases do ciclo estrial

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El Eco de Santiago : diario independiente: Año I Número 31 - 1896 Abril 09

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Análise da atividade citotóxica e mutagênica do cloridrato de fluoxetina em saccharomyces cerevisiae

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Análise da atividade citotóxica e mutagênica do cloridrato de fluoxetina em saccharomyces cerevisiae

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Substância p em medula espinal lombar de rãs após secção de nervo periférico

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Substância p em medula espinal lombar de rãs após secção de nervo periférico

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Efeito da desnervação periférica sobre a imunorreatividade da substância P em medula espinhal de rãs

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Efeito da desnervação periférica sobre a imunorreatividade da substância P em medula espinhal de rãs

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Early handling, but not maternal separation, decreases emotional responses in two paradigms of fear without changes in mesolimbic dopamine

This study aimed at identifying the effects of neonatal handling (H) and maternal separation (MS) on two paradigms of fear, learned and innate, and on the tyrosine hydroxylase (TH) immunoreactive cells in adult life. Wistar rats were daily handled with a brief maternal separation, maternal separated for 3 h or left undisturbed during the first 10 days of life. Behavioural responses in the open-field (innate fear) and conditioned fear (learned fear) were evaluated. Moreover, a semi-quantitative analysis of TH immunoreactivity in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNpc) was performed using optical densitometry and confirmed by planar measurements of neuronal density. Early handling decreased behaviour responses of innate and learned fear in adult life, while maternal separation had no significant long-lasting effect on these responses compared to the non-handled group. The behavioural effects of early handling could not be explained by changes in the density of midbrain dopaminergic cells, which were not affected by handling or maternal separation