Development of a model-based optimal control strategy of Centrifugal Chiller System

2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Optimal control of multi-zone vav air-conditioning system

2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

4-1BB Ligand Signaling to T Cells Limits T Cell Activation

4-1BB ligand (4-1BBL) and its receptor, 4-1BB, are both induced on T cells after activation, but little is known about the role of 4-1BBL. In this study we show that 4-1BBL can transmit signals that limit T cell effector activity under tolerogenic conditions. Cross-linking 4-1BBL inhibited IL-2 production in vitro, primarily with suboptimal TCR stimulation. Furthermore, naive 4-1BBL-deficient OT-II transgenic T cells displayed a greater conversion to effector T cells in vivo when responding to soluble OVA peptide in wild-type hosts, whereas development of Foxp3(+) regulatory T cells was not altered. A greater number of effector T cells also differentiated from naive wild-type OT-II T cells when transferred into 4-1BB-deficient hosts, suggesting that APC-derived 4-1BB is likely to trigger 4-1BBL. Indeed, effector T cells that could not express 4-1BBL accumulated in larger numbers in vitro when stimulated with 4-1BB-expressing mesenteric lymph node dendritic cells. 4-1BBL was expressed on T cells when Ag presentation was limiting, and 4-1BBL was aberrantly expressed at very high levels on T cells that could not express 4-1BB. Trans-ligation, Ab capture, and endocytosis experiments additionally showed that T cell-intrinsic 4-1BB regulated internalization of membrane 4-1BBL, implying that the strong induction of 4-1BB on T cells may counteract the suppressive function of 4-1BBL by limiting its availability. These data suggest that 4-1BBL expressed on T cells can restrain effector T cell development, creating a more favorable regulatory T cell to effector cell balance under tolerogenic conditions, and this may be particularly active in mucosal barrier tissues where 4-1BB-expressing regulatory dendritic cells present Ag.X11149Ysciescopu

Microwave On-Chip Bandpass Filter Based on Hybrid Coupling Technique

© 2018 IEEE. In this paper, a novel on-chip circuit design approach is proposed using hybrid coupling technique. Taking advantage of this technique, a microwave bandpass filter (BPF) is proposed as a design example for proof of concept. Based on stub-loaded stepped-impedance transmission lines and folded stepped-impedance meander line from different metal layers, the proposed BPF can generate three transmission zeros (TZs) and two transmission poles (TPs), which are excited through the hybrid mutual couplings between the inductive and capacitive metals. To understand the principle of this configuration, an equivalent LC-circuit model is presented and simplified, of which the TZs and TPs of the proposed BPF are estimated by the extracted transfer function. The calculated results exhibit good agreements with the simulated and measured ones. In addition, the bandwidth and center frequency of the proposed BPF can be tuned flexibly. Finally, to further demonstrate the feasibility of this approach in practice, the structure is implemented and fabricated in a commercial 0.13- μm SiGe (Bi)-CMOS technology. The measurement results show that the proposed BPF, whose chip size is 0.39 mm × 0.45 mm (excluding the test pads), can realize a wide bandwidth from 19.7 to 33.2 GHz with a return loss of 15.8 dB and insertion loss of 3.8 dB at the center frequency of 26.5 GHz

Research and development in HVAC system diagnosis

2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Adaptive optimal control of seawater cooling system in centralized air-conditioning system

2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Takotsubo cardiomyopathy and sepsis: a systematic review

Takotsubo cardiomyopathy (TTC) is characterized by a systolic dysfunction localized in the apical and medial aspect of the left ventricle. It is usually related to physical or emotional stress. Recent evidence highlighting the role of infection led us to analyze the links between TTC and sepsis. A systematic review of the literature was undertaken to assess any trends in clinical findings, diagnosis, and outcomes in such patients. We identified 23 selected papers reporting a total of 26 patients, having sepsis, in whom TTC occurred. For each case, we collected data identifying population characteristics, source of sepsis, clinical disease description, and the results of cardiovascular investigations. The majority of patients were females (n = 16), mean age was 62.8 (14.0 standard deviation) years, and clinical outcome was favorable in 92.3% of the cases once the management of sepsis was initiated. A better understanding of the mechanisms of sepsis-associated TTC may generate novel strategies to treat the complications of this cardiomyopathy and may even help predict and prevent its occurrence

Extracting time-frequency feature of single-channel vastus medialis EMG signals for knee exercise pattern recognition

© 2017 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The EMG signal indicates the electrophysiological response to daily living of activities, particularly to lower-limb knee exercises. Literature reports have shown numerous benefits of the Wavelet analysis in EMG feature extraction for pattern recognition. However, its application to typical knee exercises when using only a single EMG channel is limited. In this study, three types of knee exercises, i.e., flexion of the leg up (standing), hip extension from a sitting position (sitting) and gait (walking) are investigated from 14 healthy untrained subjects, while EMG signals from the muscle group of vastus medialis and the goniometer on the knee joint of the detected leg are synchronously monitored and recorded. Four types of lower-limb motions including standing, sitting, stance phase of walking, and swing phase of walking, are segmented. The Wavelet Transform (WT) based Singular Value Decomposition (SVD) approach is proposed for the classification of four lower-limb motions using a single-channel EMG signal from the muscle group of vastus medialis. Based on lower-limb motions from all subjects, the combination of five-level wavelet decomposition and SVD is used to comprise the feature vector. The Support Vector Machine (SVM) is then configured to build a multiple-subject classifier for which the subject independent accuracy will be given across all subjects for the classification of four types of lower-limb motions. In order to effectively indicate the classification performance, EMG features from time-domain (e.g., Mean Absolute Value (MAV), Root-Mean-Square (RMS), integrated EMG (iEMG), Zero Crossing (ZC)) and frequency-domain (e.g., Mean Frequency (MNF) and Median Frequency (MDF)) are also used to classify lower-limb motions. The five-fold cross validation is performed and it repeats fifty times in order to acquire the robust subject independent accuracy. Results show that the proposed WT-based SVD approach has the classification accuracy of 91.85% ±0.88% which outperforms other feature models

Experimental study on sensor fault detection and diagnosis and estimation of centrifugal chiller system

2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Adaptive Transmission Planning: Implementing a New Paradigm for Managing Economic Risks in Grid Expansion

The problem of whether, where, when, and what types of transmission facilities to build in terms of minimizing costs and maximizing net economic benefits has been a challenge for the power industry from the beginning-ever since Thomas Edison debated whether to create longer dc distribution lines (with their high losses) or build new power stations in expanding his urban markets. Today?s planning decisions are far more complex, as grids cover the continent and new transmission, generation, and demand-side technologies emerge