In situ loading and delivery of short single- And double-stranded dna by supramolecular organic frameworks

Short DNA represents an important class of biomacromolecules that are widely applied in gene therapy, editing, and modulation. However, the development of simple and reliable methods for their intracellular delivery remains a challenge. Herein, we describe that seven water-soluble, homogeneous supramolecular organic frameworks (SOFs) with a well-defined pore size and high stability in water that can accomplish in situ inclusion of single-stranded (ss) and double-stranded (ds) DNA (21, 23, and 58 nt) and effective intracellular delivery (including two noncancerous and six cancerous cell lines). Fluorescence quenching experiments for single and double endlabeled ss- and ds-DNA support that the DNA sequences can be completely enveloped by the SOFs. Confocal laser scanning microscopy and flow cytometry reveal that five of the SOFs exhibit excellent delivery efficiencies that, in most of the studied cases, outperform the commercial standard Lipo2000, even at low SOF-nucleic acid ratios. In addition to high delivery efficiencies, the watersoluble, self-assembled SOF carriers have a variety of advantages, including convenient preparation, high stability, and in situ DNA inclusion, which are all critical for practical applications in nucleic acid delivery

A model for ranking sentence pairs in parallel corpora

In this paper, the problem of ranking sentence pairs in parallel corpora was addressed for the first time. To solve this problem, a novel model was proposed. In this model, both syntax features and semantics features of sentence pairs are considered. Since most today's Statistical Machine Translation models depend on word alignment, features related to word alignment information are also included. Two experiments were carried out and the results showed that the model had promising performance

The association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma

Program no. 686postprin

Single Spin Asymmetry in Lepton Angular Distribution of Drell-Yan Processes

We study the single spin asymmetry in the lepton angular distribution of Drell-Yan processes in the frame work of collinear factorization. The asymmetry has been studied in the past and different results have been obtained. In our study we take an approach different than that used in the existing study. We explicitly calculate the transverse-spin dependent part of the differential cross-section with suitable parton states. Because the spin is transverse, one has to take multi-parton states for the purpose. Our result agrees with one of the existing results. A possible reason for the disagreement with others is discussed.Comment: Typos corrected. Conclusions unchange

Automatic extraction of Chinese terms

This paper presents a hybrid method of Chinese Term Extraction, combining statistical information with linguistic knowledge. In this paper, we propose the Local Reoccurrence Measure, which greatly improves the automatic term recognition, especially for new terms and other terms with low frequency. This measure can also be applied to term extraction of foreign language and other applications

Public views towards community health and hospital-based outpatient services and their utilisation in Zhejiang, China: a mixed methods study

published_or_final_versio

Deformation of the Fermi surface in the extended Hubbard model

The deformation of the Fermi surface induced by Coulomb interactions is investigated in the t-t'-Hubbard model. The interplay of the local U and extended V interactions is analyzed. It is found that exchange interactions V enhance small anisotropies producing deformations of the Fermi surface which break the point group symmetry of the square lattice at the Van Hove filling. This Pomeranchuck instability competes with ferromagnetism and is suppressed at a critical value of U(V). The interaction V renormalizes the t' parameter to smaller values what favours nesting. It also induces changes on the topology of the Fermi surface which can go from hole to electron-like what may explain recent ARPES experiments.Comment: 5 pages, 4 ps figure

香港地区重力固体潮和海潮负荷特征研究

Author name used in this publication: 孙和平Author name used in this publication: 许厚泽Author name used in this publication: 陈武Author name used in this publication: 陈晓东Author name used in this publication: 周江存Author name used in this publication: 刘明Author name used in this publication: 高山Title in Traditional Chinese: 香港地區重力固體潮和海潮負荷特征研究Journal title in Traditional Chinese: 地球物理學報2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Formation of P In defect in annealed liquid-encapsulated Czochralski InP

Fourier transform infrared spectroscopy measurements have been carried out on liquid-encapsulated Czochralski-grown undoped InP wafers, which reproducibly become semi-insulating upon annealing in an ambient of phosphorus at 800-900°C. The measurements reveal a high concentration of hydrogen complexes in the form V InH 4 existing in the material before annealing in agreement with recent experimental studies. It is argued that the dominant and essential process producing the semi-insulating behavior is the compensation produced by an EL 2-like deep donor phosphorus antisite defect, which is formed by the dissociation of the hydrogen complexes during the process of annealing. The deep donor compensates acceptors, the majority of which are shallow residual acceptor impurities and deep hydrogen associated V In and isolated V In levels, produced at the first stage of the dissociation of the V InH 4 complex. The high concentration of indium vacancies produced by the dissociation are the precursor of the EL 2-like phosphorus antisite. These results show the importance of hydrogen on the electrical properties of InP and indicate that this largely results from low formation energy of the complex V InH 4 in comparison with that of an isolated V In. © 1998 American Institute of Physics.published_or_final_versio