sj-docx-1-jdr-10.1177_00220345231207309 – Supplemental material for ASH2L, Core Subunit of H3K4 Methylation Complex, Regulates Amelogenesis

Supplemental material, sj-docx-1-jdr-10.1177_00220345231207309 for ASH2L, Core Subunit of H3K4 Methylation Complex, Regulates Amelogenesis by X. Zhu, Z. Ma, F. Xie and J. Wang in Journal of Dental Research</p

Exogenous niacin treatment increases NADPH oxidase in kiwifruit

<div><p>Abstract Kiwifruit are a popular fruit worldwide; however, plant growth is threatened by abiotic stresses such as drought and high temperatures. Niacin treatment in plants has been shown to increase NADPH levels, thus enhancing abiotic stresses tolerance. Here, we evaluate the effect of niacin solution spray treatment on NADPH levels in the kiwifruit cultivars Hayward and Xuxiang. We found that spray treatment with niacin solution promoted NADPH and NADP+ levels and decreased both O2·- production and H2O2 contents in leaves during a short period. In fruit, NADPH contents increased during early development, but decreased later. However, no effect on NADP+ levels has been observed throughout fruit development. In summary, this report suggests that niacin may be used to increase NADPH oxidases, thus increasing stress-tolerance in kiwifruit during encounter of short-term stressful conditions.</p></div

Association of off-the-job training with work performance and work-family conflict among physicians: A cross-sectional study in China

Objectives To determine whether experiences of off-the-job training in domestic (DT) and overseas study (OS) settings are associated with work performance and work-family conflict in physicians. Design, setting and participants We conducted a national cross-sectional survey in 77 public hospitals across seven provinces in China between July 2014 and April 2015. Participants were 3182 physicians. Exposure Participants were categorised into four groups: none, DT only, OS only and DT and OS. Primary outcome measures Work performance was assessed by work engagement, career attrition and patient-centred care. Work-family conflict was assessed by affecting care for family, feeling guilty towards family and receiving complaints from family. Results A total of 25.89% participants had experienced DT only, 8.71% OS only and 8.47% DT and OS. After adjustment for potential confounders, participants who had experiences of DT and OS compared with those with no training were more likely to report positive work performance (pride in work: OR=2.11, 95% CI: 1.43 to 3.10; enjoyment of work: OR=1.67, 95% CI: 1.11 to 2.51; turnover intention: OR=0.54, 95% CI: 0.38 to 0.77; early retirement: OR=0.63, 95% CI: 0.45 to 0.89; and exhaustion: OR=0.66, 95% CI: 0.45 to 0.98) and less work-family conflicts (feeling guilty towards family: OR=0.51, 95% CI: 0.35 to 0.74; and complaints from family: OR=0.66, 95% CI: 0.47 to 0.91). We found no obvious association between DT/OS experience with patient-centred care. Conclusions Physicians with DT and OS experiences are more likely to have better work performance and less work-family conflict than those without such experience. Physicians face increasing pressure to pursue continuing education and experience associated distress. Therefore, hospitals and government policy-makers should promote DT and OS

Defect Chemistry of Ceria Nanorods

Ceria nanorods were investigated using in situ Raman and FTIR spectroscopies for CO adsorption and subsequent reaction with water at 200 and 350 °C. The involvement of defects in ceria nanorods during CO adsorption and reaction with H₂O is dependent on the temperature. At 200 °C, most of the carbonate and formate species formed in CO do not involve the formation of defects, while at 350 °C all of the carbonates and formates formed can be correlated to the formation of defects (15% by formates and 85% by mono/bidentate carbonates). Finally, at 350 °C very stable polydentate carbonates are formed that do not induce defects and cannot be regenerated with water

Additional file 1: of DS1/OsEMF1 interacts with OsARF11 to control rice architecture by regulation of brassinosteroid signaling

Table S1 Comparison of agronomic traits between WT and ds1. Table S2 Primers used in mapping. Table S3 Primers used in real-time PCR and vector construction. Figure S1 Relative expression levels of cell wall synthesis-related genes (CESA6, IRX10L, GT8, UGA4e, and CSLF6) and cell expansion-related genes, Exp1, ExpA8, ExpA10, ExpA17, ExpA30, ExpB2, ExpB3, ExpB5, and ExpB12. Figure S2 Alignment amino acid sequences of DS1 and AtEMF1. (DOC 1088 kb

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation