200 research outputs found
Transport in the Laughlin quasiparticle interferometer: Evidence for topological protection in an anyonic qubit
We report experiments on temperature and Hall voltage bias dependence of the
superperiodic conductance oscillations in the novel Laughlin quasiparticle
interferometer, where quasiparticles of the 1/3 fractional quantum Hall fluid
execute a closed path around an island of the 2/5 fluid. The amplitude of the
oscillations fits well the quantum-coherent thermal dephasing dependence
predicted for a two point-contact chiral edge channel interferometer in the
full experimental temperature range 10.2<T<141 mK. The temperature dependence
observed in the interferometer is clearly distinct from the behavior in
single-particle resonant tunneling and Coulomb blockade devices. The 5h/e flux
superperiod, originating in the anyonic statistical interaction of Laughlin
quasiparticles, persists to a relatively high T~140 mK. This temperature is
only an order of magnitude less than the 2/5 quantum Hall gap. Such protection
of quantum logic by the topological order of fractional quantum Hall fluids is
expected to facilitate fault-tolerant quantum computation with anyons.Comment: 13 pages, 10 figure
HDAC inhibitors in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors. Although
clinical advances in AML have been made, especially in young patients, long-term disease-free
survival remains poor, making this disease an unmet therapeutic challenge. Epigenetic alterations
and mutations in epigenetic regulators contribute to the pathogenesis of AML, supporting the
rationale for the use of epigenetic drugs in patients with AML. While hypomethylating agents have
already been approved in AML, the use of other epigenetic inhibitors, such as histone deacetylases
(HDAC) inhibitors (HDACi), is under clinical development. HDACi such as Panobinostat, Vorinostat,
and Tricostatin A have been shown to promote cell death, autophagy, apoptosis, or growth arrest in
preclinical AML models, yet these inhibitors do not seem to be effective as monotherapies, but rather
in combination with other drugs. In this review, we discuss the rationale for the use of different
HDACi in patients with AML, the results of preclinical studies, and the results obtained in clinical
trials. Although so far the results with HDACi in clinical trials in AML have been modest, there are
some encouraging data from treatment with the HDACi Pracinostat in combination with DNA
demethylating agents
Analysis of Shot Noise at Finite Temperatures in Fractional Quantum Hall Edge States
We investigate shot noise at {\it finite temperatures} induced by the
quasi-particle tunneling between fractional quantum Hall (FQH) edge states. The
resulting Fano factor has the peak structure at a certain bias voltage. Such a
structure indicates that quasi-particles are weakly {\it glued} due to thermal
fluctuation. We show that the effect makes it possible to probe the difference
of statistics between FQH states where quasi-particles have the
same unit charge.Finally we propose a way to indirectly obtain statistical
angle in hierarchical FQH states.Comment: 5 pages, 3 figure
Adding flavor to the gravity dual of non-commutative gauge theories
We study the addition of flavor degrees of freedom to the supergravity dual
of the non-commutative deformation of the maximally supersymmetric gauge
theories. By considering D7 flavor branes in the probe approximation and
studying their fluctuations we extract the spectrum of scalar and vector mesons
as a function of the non-commutativity. We find that the spectrum for very
large non-commutative parameter is equal to the one in the commutative theory,
while for some intermediate values of the non-commutativity some of the modes
disappear from the discrete spectrum. We also study the semiclassical dynamics
of rotating open strings attached to the D7-brane, which correspond to mesons
with large spin. Under the effect of the non-commutativity the open strings get
tilted. However, at small(large) distances they display the same Regge-like
(Coulombic) behaviour as in the commutative theory. We also consider the
addition of D5-flavor branes to the non-commutative deformation of the N=1
supersymmetric Maldacena-Nunez background.Comment: 50 pages, 9 figures, LaTeX; v2: minor improvements, references added;
v3: typos correcte
Full Counting Statistics of Multiple Andreev Reflections in incoherent diffusive superconducting junctions
We present a theory for the full distribution of current fluctuations in
incoherent diffusive superconducting junctions, subjected to a voltage bias.
This theory of full counting statistics of incoherent multiple Andreev
reflections is valid for arbitrary applied voltage. We present a detailed
discussion of the properties of the first four cumulants as well as the low and
high voltage regimes of the full counting statistics. The work is an extension
of the results of Pilgram and the author, Phys. Rev. Lett. 94, 086806 (2005).Comment: Included in special issue Spin Physics of Superconducting
heterostructures of Applied Physics A: Materials Science & Processin
Anyonic interferometry and protected memories in atomic spin lattices
Strongly correlated quantum systems can exhibit exotic behavior called
topological order which is characterized by non-local correlations that depend
on the system topology. Such systems can exhibit remarkable phenomena such as
quasi-particles with anyonic statistics and have been proposed as candidates
for naturally fault-tolerant quantum computation. Despite these remarkable
properties, anyons have never been observed in nature directly. Here we
describe how to unambiguously detect and characterize such states in recently
proposed spin lattice realizations using ultra-cold atoms or molecules trapped
in an optical lattice. We propose an experimentally feasible technique to
access non-local degrees of freedom by performing global operations on trapped
spins mediated by an optical cavity mode. We show how to reliably read and
write topologically protected quantum memory using an atomic or photonic qubit.
Furthermore, our technique can be used to probe statistics and dynamics of
anyonic excitations.Comment: 14 pages, 6 figure
Holographic flavor on the Higgs branch
In this paper we study the holographic dual, in several spacetime dimensions,
of the Higgs branch of gauge theories with fundamental matter. These theories
contain defects of various codimensionalities, where the matter fields are
located. In the holographic description the matter is added by considering
flavor brane probes in the supergravity backgrounds generated by color branes,
while the Higgs branch is obtained when the color and flavor branes recombine
with each other. We show that, generically, the holographic dual of the Higgs
phase is realized by means of the addition of extra flux on the flavor branes
and by choosing their appropriate embedding in the background geometry. This
suggests a dielectric interpretation in terms of the color branes, whose vacuum
solutions precisely match the F- and D-flatness conditions obtained on the
field theory side. We further compute the meson mass spectra in several cases
and show that when the defect added has codimension greater than zero it
becomes continuous and gapless.Comment: 59 pages, 1 figure;v2: references adde
Recurrent Modification of a Conserved Cis-Regulatory Element Underlies Fruit Fly Pigmentation Diversity
The development of morphological traits occurs through the collective action of networks of genes connected at the level of gene expression. As any node in a network may be a target of evolutionary change, the recurrent targeting of the same node would indicate that the path of evolution is biased for the relevant trait and network. Although examples of parallel evolution have implicated recurrent modification of the same gene and cis-regulatory element (CRE), little is known about the mutational and molecular paths of parallel CRE evolution. In Drosophila melanogaster fruit flies, the Bric-à-brac (Bab) transcription factors control the development of a suite of sexually dimorphic traits on the posterior abdomen. Female-specific Bab expression is regulated by the dimorphic element, a CRE that possesses direct inputs from body plan (ABD-B) and sex-determination (DSX) transcription factors. Here, we find that the recurrent evolutionary modification of this CRE underlies both intraspecific and interspecific variation in female pigmentation in the melanogaster species group. By reconstructing the sequence and regulatory activity of the ancestral Drosophila melanogaster dimorphic element, we demonstrate that a handful of mutations were sufficient to create independent CRE alleles with differing activities. Moreover, intraspecific and interspecific dimorphic element evolution proceeded with little to no alterations to the known body plan and sex-determination regulatory linkages. Collectively, our findings represent an example where the paths of evolution appear biased to a specific CRE, and drastic changes in function were accompanied by deep conservation of key regulatory linkages. © 2013 Rogers et al
Moduli Spaces of Cold Holographic Matter
We use holography to study (3+1)-dimensional N=4 supersymmetric Yang-Mills
theory with gauge group SU(Nc), in the large-Nc and large-coupling limits,
coupled to a single massless (n+1)-dimensional hypermultiplet in the
fundamental representation of SU(Nc), with n=3,2,1. In particular, we study
zero-temperature states with a nonzero baryon number charge density, which we
call holographic matter. We demonstrate that a moduli space of such states
exists in these theories, specifically a Higgs branch parameterized by the
expectation values of scalar operators bilinear in the hypermultiplet scalars.
At a generic point on the Higgs branch, the R-symmetry and gauge group are
spontaneously broken to subgroups. Our holographic calculation consists of
introducing a single probe Dp-brane into AdS5 times S^5, with p=2n+1=7,5,3,
introducing an electric flux of the Dp-brane worldvolume U(1) gauge field, and
then obtaining explicit solutions for the worldvolume fields dual to the scalar
operators that parameterize the Higgs branch. In all three cases, we can
express these solutions as non-singular self-dual U(1) instantons in a
four-dimensional space with a metric determined by the electric flux. We
speculate on the possibility that the existence of Higgs branches may point the
way to a counting of the microstates producing a nonzero entropy in holographic
matter. Additionally, we speculate on the possible classification of
zero-temperature, nonzero-density states described holographically by probe
D-branes with worldvolume electric flux.Comment: 56 pages, 8 PDF images, 4 figure
Holographic flavor in theories with eight supercharges
We review the holographic duals of gauge theories with eight supercharges
obtained by adding very few flavors to pure supersymmetric Yang-Mills with
sixteen supercharges. Assuming a brane-probe limit, the gravity duals are
engineered in terms of probe branes (the so-called flavor brane) in the
background of the color branes. Both types of branes intersect on a given
subspace in which the matter is confined. The gauge theory dual is thus the
corresponding flavoring of the gauge theory with sixteen supercharges. Those
theories have in general a non-trivial phase structure; which is also captured
in a beautiful way by the gravity dual. Along the lines of the gauge/gravity
duality, we review also some of the results on the meson spectrum in the
different phases of the theories.Comment: Invited review submitted to IJMP
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