9 research outputs found
Temporal Asynchrony of Trophic Status Between Mainstream and Tributary Bay Within a Giant Dendritic Reservoir: The Role of Local-Scale Regulators
Limnologists have regarded temporal coherence (synchrony) as a powerful tool for identifying the relative importance of local-scale regulators and regional climatic drivers on lake ecosystems. Limnological studies on Asian reservoirs have emphasized that climate and hydrology under the influences of monsoon are dominant factors regulating seasonal patterns of lake trophic status; yet, little is known of synchrony or asynchrony of trophic status in the single reservoir ecosystem. Based on monthly monitoring data of chlorophyll a, transparency, nutrients, and nonvolatile suspended solids (NVSS) during 1-year period, the present study evaluated temporal coherence to test whether local-scale regulators disturb the seasonal dynamics of trophic state indices (TSI) in a giant dendritic reservoir, China (Three Gorges Reservoir, TGR). Reservoir-wide coherences for TSICHL, TSISD, and TSITP showed dramatic variations over spatial scale, indicating temporal asynchrony of trophic status. Following the concept of TSI differences, algal productivity in the mainstream of TGR and Xiangxi Bay except the upstream of the bay were always limited by nonalgal turbidity (TSICHL−TSISD <0) rather than nitrogen and phosphorus (TSICHL−TSITN <0 and TSICHL−TSITP <0). The coherence analysis for TSI differences showed that local processes of Xiangxi Bay were the main responsible for local asynchrony of nonalgal turbidity limitation levels. Regression analysis further proved that local temporal asynchrony for TSISD and nonalgal turbidity limitation levels were regulated by local dynamics of NVSS, rather than geographical distance. The implications of the present study are to emphasize that the results of trophic status obtained from a single environment (reservoir mainstream) cannot be extrapolated to other environments (tributary bay) in a way that would allow its use as a sentinel site
A proteomic profile of synoviocyte lesions microdissected from formalin-fixed paraffin-embedded synovial tissues of rheumatoid arthritis
A critical review of microplastic pollution in urban freshwater environments and legislative progress in China: Recommendations and insights
Freshwater systems are vitally important, supporting diversity and providing a range of ecosystem services. In China, rapid urbanization (over 800 million urban population) has led to multiple anthropogenic pressures that threaten urban freshwater environments. Microplastics (<5 mm) result from intensive production and use of plastic materials, but their effects in urban freshwater environments remain poorly understood. Rising concerns over the ecological effects of microplastics have resulted in increased attention being given to this contaminant in Chinese freshwater systems. Some studies provide quantitative data on contamination loads, but in general relevant knowledge in freshwater environment remains narrow in China, and lacking adequate understanding of threshold levels for detrimental effects. Notably, non-standardized sample collection and processing techniques for point and non-point sources have hindered comparisons of contamination loads and associated risk. Meanwhile, legislative frameworks for managing microplastics in China remain in their infancy. This manuscript critically reviews what is known of the nature and magnitude of microplastic pollution in Chinese freshwater environments, and summarizes relevant Chinese legislation. It provides recommendations for improving the legislative framework in China and identifies research gaps that need to be addressed to improve management and regulatory strategies for dealing with microplastic pollution in Chinese urban freshwater environments
κ-Carrageenan-derived carbon dots for highly selective and sensitive detection of Fe3+ and oxytetracycline
Protein kinase C-η controls CTLA-4–mediated regulatory T cell function
Regulatory T cells (T(reg) cells), which maintain immune homeostasis and self-tolerance, form an immunological synapse (IS) with antigen-presenting cells (APCs). However, signaling events at the T(reg) IS remain unknown. Here we show that protein kinase C-η (PKC-η) associated with CTLA-4 and was recruited to the T(reg) IS. PKC-η-deficient T(reg) cells displayed defective suppressive activity, including suppression of tumor immunity but not autoimmune colitis. Phosphoproteomic analysis revealed an association between CTLA-4-PKC-η and the GIT-PIX-PAK complex, an IS-localized focal adhesion complex. Defective activation of this complex in PKC-η-deficient T(reg) cells was associated with reduced CD86 depletion from APCs by T(reg) cells. These results reveal a novel CTLA-4-PKC-η signaling axis required for contact-dependent suppression, implicating this pathway as a potential cancer immunotherapy target