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Durable and ductile double-network material for dust control
Dust generation is a world-wide issue due to its serious deleterious effects on the environment, human health and safety, and the economy. Although various dust suppression methods have been used for decades, some critical drawbacks in state-of-the-art technology still remain unsolved, such as short-lasting, ground water impact, and prone to water. This work reports a soil stabilizer based on non-toxic material and forms a ductile and durable double-network in soil, namely “D3 soil stabilizer”, which not only improves soil mechanical toughness of surface soil but also suppresses dust generation. A copolymer comprising hydrophilic and hydrophobic components combined with enzyme-induced carbonate precipitation is utilized as an in-situ gelation binder to soil particle. The tunable hydrophobic-to-hydrophilic component ratio minimizes undesirable soil matrix expansion and mechanical strength loss upon experiencing wet-dry processes, while still retains good water affinity. We further demonstrated controllable treatment depth by fine-tuning precursor composition, which is essential to minimize environmental impact. The double-network morphology with carbonate precipitate embedded uniformly in polymer matrix is observed via microscopic imaging. The nature of outstanding ductility, high durability against water, and good long-term stability were supported by systematic unconfined compressive strength (UCS) measurements on treated soil, which show strong inter-particles binding, good retention of peak strength, increased strain at peak strength, and increased toughness after soil samples have experienced wet-dry processes
Fermion localization on asymmetric two-field thick branes
In this paper we investigate the localization of fermions on asymmetric thick
branes generated by two scalars and . In order to trap fermions on
the asymmetric branes with kink-like warp factors, the couplings with the
background scalars are introduced, where
is a function of and . We find that the coupling
do not support the localization of 4-dimensional
fermions on the branes. While, for the case
, which is the kink-fermion
coupling corresponding to one-scalar-generated brane scenarios, the zero mode
of left-handed fermions could be trapped on the branes under some conditions.Comment: v2: 11 pages, 4 figures, accepted by CQ
Persistence, extinction and spatio-temporal synchronization of SIRS cellular automata models
Spatially explicit models have been widely used in today's mathematical
ecology and epidemiology to study persistence and extinction of populations as
well as their spatial patterns. Here we extend the earlier work--static
dispersal between neighbouring individuals to mobility of individuals as well
as multi-patches environment. As is commonly found, the basic reproductive
ratio is maximized for the evolutionary stable strategy (ESS) on diseases'
persistence in mean-field theory. This has important implications, as it
implies that for a wide range of parameters that infection rate will tend
maximum. This is opposite with present results obtained in spatial explicit
models that infection rate is limited by upper bound. We observe the emergence
of trade-offs of extinction and persistence on the parameters of the infection
period and infection rate and show the extinction time having a linear
relationship with respect to system size. We further find that the higher
mobility can pronouncedly promote the persistence of spread of epidemics, i.e.,
the phase transition occurs from extinction domain to persistence domain, and
the spirals' wavelength increases as the mobility increasing and ultimately, it
will saturate at a certain value. Furthermore, for multi-patches case, we find
that the lower coupling strength leads to anti-phase oscillation of infected
fraction, while higher coupling strength corresponds to in-phase oscillation.Comment: 12page
Domain wall brane in squared curvature gravity
We suggest a thick braneworld model in the squared curvature gravity theory.
Despite the appearance of higher order derivatives, the localization of gravity
and various bulk matter fields is shown to be possible. The existence of the
normalizable gravitational zero mode indicates that our four-dimensional
gravity is reproduced. In order to localize the chiral fermions on the brane,
two types of coupling between the fermions and the brane forming scalar is
introduced. The first coupling leads us to a Schr\"odinger equation with a
volcano potential, and the other a P\"oschl-Teller potential. In both cases,
the zero mode exists only for the left-hand fermions. Several massive KK states
of the fermions can be trapped on the brane, either as resonant states or as
bound states.Comment: 18 pages, 5 figures and 1 table, references added, improved version
to be published in JHE
Effects of Multi-Surface Modification on Curie temperature of ferroelectric films
Within the framework of mean field theory, we study the effects of
multi-surface modification on Curie temperature of ferroelectric films using
the transverse Ising model. The general nonlinear equations for Curie
temperature of multi-surface ferroelectric films with arbitrary exchange
constants and transverse fields are derived by the transfer matrix method. As
an example, we consider a film consisting of top surface layers, bulk layers
and bottom surface layers. Two types of surface modifications, modifications of
a surface exchange constant and a surface transverse field are taken into
account. The dependence of Curie temperature on the surface layer numbers, bulk
layer numbers, surface exchange constants, surface transverse fields and bulk
transverse fields is discussed.Comment: 11 pages, 5 figure
A Path Algorithm for Constrained Estimation
Many least squares problems involve affine equality and inequality
constraints. Although there are variety of methods for solving such problems,
most statisticians find constrained estimation challenging. The current paper
proposes a new path following algorithm for quadratic programming based on
exact penalization. Similar penalties arise in regularization in model
selection. Classical penalty methods solve a sequence of unconstrained problems
that put greater and greater stress on meeting the constraints. In the limit as
the penalty constant tends to , one recovers the constrained solution.
In the exact penalty method, squared penalties are replaced by absolute value
penalties, and the solution is recovered for a finite value of the penalty
constant. The exact path following method starts at the unconstrained solution
and follows the solution path as the penalty constant increases. In the
process, the solution path hits, slides along, and exits from the various
constraints. Path following in lasso penalized regression, in contrast, starts
with a large value of the penalty constant and works its way downward. In both
settings, inspection of the entire solution path is revealing. Just as with the
lasso and generalized lasso, it is possible to plot the effective degrees of
freedom along the solution path. For a strictly convex quadratic program, the
exact penalty algorithm can be framed entirely in terms of the sweep operator
of regression analysis. A few well chosen examples illustrate the mechanics and
potential of path following.Comment: 26 pages, 5 figure
Tensor Regression with Applications in Neuroimaging Data Analysis
Classical regression methods treat covariates as a vector and estimate a
corresponding vector of regression coefficients. Modern applications in medical
imaging generate covariates of more complex form such as multidimensional
arrays (tensors). Traditional statistical and computational methods are proving
insufficient for analysis of these high-throughput data due to their ultrahigh
dimensionality as well as complex structure. In this article, we propose a new
family of tensor regression models that efficiently exploit the special
structure of tensor covariates. Under this framework, ultrahigh dimensionality
is reduced to a manageable level, resulting in efficient estimation and
prediction. A fast and highly scalable estimation algorithm is proposed for
maximum likelihood estimation and its associated asymptotic properties are
studied. Effectiveness of the new methods is demonstrated on both synthetic and
real MRI imaging data.Comment: 27 pages, 4 figure
Knotting probabilities after a local strand passage in unknotted self-avoiding polygons
We investigate the knotting probability after a local strand passage is
performed in an unknotted self-avoiding polygon on the simple cubic lattice. We
assume that two polygon segments have already been brought close together for
the purpose of performing a strand passage, and model this using Theta-SAPs,
polygons that contain the pattern Theta at a fixed location. It is proved that
the number of n-edge Theta-SAPs grows exponentially (with n) at the same rate
as the total number of n-edge unknotted self-avoiding polygons, and that the
same holds for subsets of n-edge Theta-SAPs that yield a specific
after-strand-passage knot-type. Thus the probability of a given
after-strand-passage knot-type does not grow (or decay) exponentially with n,
and we conjecture that instead it approaches a knot-type dependent amplitude
ratio lying strictly between 0 and 1. This is supported by critical exponent
estimates obtained from a new maximum likelihood method for Theta-SAPs that are
generated by a composite (aka multiple) Markov Chain Monte Carlo BFACF
algorithm. We also give strong numerical evidence that the after-strand-passage
knotting probability depends on the local structure around the strand passage
site. Considering both the local structure and the crossing-sign at the strand
passage site, we observe that the more "compact" the local structure, the less
likely the after-strand-passage polygon is to be knotted. This trend is
consistent with results from other strand-passage models, however, we are the
first to note the influence of the crossing-sign information. Two measures of
"compactness" are used: the size of a smallest polygon that contains the
structure and the structure's "opening" angle. The opening angle definition is
consistent with one that is measurable from single molecule DNA experiments.Comment: 31 pages, 12 figures, submitted to Journal of Physics
A vine copula mixed effect model for trivariate meta-analysis of diagnostic test accuracy studies accounting for disease prevalence
A bivariate copula mixed model has been recently proposed to synthesize diagnostic test accuracy studies and it has been shown that it is superior to the standard generalized linear mixed model in this context. Here, we call trivariate vine copulas to extend the bivariate meta-analysis of diagnostic test accuracy studies by accounting for disease prevalence. Our vine copula mixed model includes the trivariate generalized linear mixed model as a special case and can also operate on the original scale of sensitivity, specificity, and disease prevalence. Our general methodology is illustrated by re-analyzing the data of two published meta-analyses. Our study suggests that there can be an improvement on trivariate generalized linear mixed model in fit to data and makes the argument for moving to vine copula random effects models especially because of their richness, including reflection asymmetric tail dependence, and computational feasibility despite their three dimensionality
Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics
The development of plasma biomarkers could facilitate early detection, risk assessment and therapeutic monitoring in Alzheimer's disease (AD). Alterations in ceramides and sphingomyelins have been postulated to play a role in amyloidogensis and inflammatory stress related neuronal apoptosis; however few studies have conducted a comprehensive analysis of the sphingolipidome in AD plasma using analytical platforms with accuracy, sensitivity and reproducibility.We prospectively analyzed plasma from 26 AD patients (mean MMSE 21) and 26 cognitively normal controls in a non-targeted approach using multi-dimensional mass spectrometry-based shotgun lipidomics to determine the levels of over 800 molecular species of lipids. These data were then correlated with diagnosis, apolipoprotein E4 genotype and cognitive performance. Plasma levels of species of sphingolipids were significantly altered in AD. Of the 33 sphingomyelin species tested, 8 molecular species, particularly those containing long aliphatic chains such as 22 and 24 carbon atoms, were significantly lower (p<0.05) in AD compared to controls. Levels of 2 ceramide species (N16:0 and N21:0) were significantly higher in AD (p<0.05) with a similar, but weaker, trend for 5 other species. Ratios of ceramide to sphingomyelin species containing identical fatty acyl chains differed significantly between AD patients and controls. MMSE scores were correlated with altered mass levels of both N20:2 SM and OH-N25:0 ceramides (p<0.004) though lipid abnormalities were observed in mild and moderate AD. Within AD subjects, there were also genotype specific differences.In this prospective study, we used a sensitive multimodality platform to identify and characterize an essentially uniform but opposite pattern of disruption in sphingomyelin and ceramide mass levels in AD plasma. Given the role of brain sphingolipids in neuronal function, our findings provide new insights into the AD sphingolipidome and the potential use of metabolomic signatures as peripheral biomarkers
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