Propolis – beekeeping medicinal product

The paper presents the healing properties and biological activity of propolis, commonly known as bee glue. Propolis is a natural product collected by bees from buds of plants and bark of trees, then moistened with bee enzymes. Propolis is widely used for general treatment, skin affections, and as an anti-inflammatory agent for ulcers and hard-to-heal wounds. Propolis, due to its properties, is called an antibiotic of the 21st century

Celebrity endorsement "- as a tool to promote a telecommunications company. Case Study - company P4.

Poniższa praca zbudowana jest z czterech rozdziałów podzielonych na mniejsze podrozdziały w celu zachowania dokładnego i uporządkowanego procesu myślowego zachowującego ciąg przyczynowo - skutkowy. Pierwsze dwa poświęcone są podstawom teoretycznym dziedziny marketingu, zaś kolejne opisom praktycznego zastosowania koncepcji celebrity endorsement, a także jej realizacji w ramach strategii operatora Play. Pierwsze trzy części powstały w oparciu o wiedzę z literatury, natomiast czwarty wykorzystuje badania przeprowadzone przez firmę, jak też wiele innych badawczych materiałów wewnętrznych opracowanych przez organizację. Wychodząc od części teoretycznej, pierwszy rozdział zawiera wyjaśnienie podstaw, od których wywodzi się sama idea promocji i reklamy, a więc bada w szerokim zakresie to, czym jest marketing. Przybliża historię, jak ewaluował on od czasów powstania, tworzenia pierwszych koncepcji po definicję współczesnego nowoczesnego zarządzania strategią marketingową. Pozwala on zrozumieć rolę marketingu i umiejscowić ją w kontekście funkcjonowania przedsiębiorstw, zarówno historycznie, jak i współcześnie. Rozdział ten niesie wyjaśnienie jednego z kluczowych pojęć nadającego znaczenie tej pracy, czyli marketingu – mix – niejako trzonu wszystkich planów marketingowych. Rozdział drugi stanowi obszerną bazę wiedzy zawierająca objaśnienia dotyczące reklamy, jako narzędzia komunikacji z klientem. W ujęciu proporcjonalnym, przyjąć można, że połowa wagi tego rozdziału przypisana jest zagadnieniom związanym z teoretycznymi aspektami reklamy, takimi jak definicja i tło historyczne. Po prezentacji punktów wyjaśniających samą istotę reklamy, dalsza część skupia się na zagadnieniach dotyczących metod konstrukcji i funkcjonowania reklamy. Ponieważ reklama stanowi jeden z głównych problemów badawczych owej pracy, stąd tak wiele treści objaśniających zagadnienia, czym w istocie reklama jest i jakimi przymiotami się charakteryzuje. Trzecia część pracy przeznaczona jest na tytułowe pojęcie celebrity endorsement i na wszystkich zagadnieniach związanych z tą koncepcją. Naświetla ona postać osoby znanej: jej cechy, typy osób występujących reklamie, zasady doboru celebryty do reklamy, jak i metody ich oddziaływania na konsumenta. Rozdział ten daje też możliwość poznania zjawiska, w jaki sposób oddziałują one swym wizerunkiem na społeczeństwo.Ostatni moduł, stanowi niemal esencję całej pracy. Został on podzielony na pięć mniejszych segmentów, z których każdy ma zadanie przybliżyć potwierdzenie postawionej tezy. Pierwsza część to charakterystyka firmy P4 sp. z o. o.: jej historii powstania rozwoju, domeny i celów działania. Następnie przytoczony zostaje opis jej strategii marketingowej działań podejmowanych w strukturach marketingowych oraz ich ogólna definicja. . Mowa tutaj zarówno o działaniach z zakresu ATL, jaki i BTL. Następnie działania te przedstawione są bezpośrednio w przełożeniu na trwającą od 2012 roku komunikację multicelebrycką.This work is composed of four chapters divided into smaller sections to maintain an accurate and orderly thought process that preserves the sequence of cause - effect. The first two are devoted to theoretical foundations of marketing, and further descriptions of the practical application of the concept of celebrity endorsement, as well as its implementation within the operator's strategy Play. The first three parts are based on knowledge of literature, and the fourth utilizes research conducted by the company, as well as many other internal materials research developed by the organization.Starting from the theoretical part, the first chapter contains an explanation of the basics, from which is derived the idea of ​​promotion and advertising, and so explores a wide range of what it is marketing. Brings the story of how he evolved since the inception, creation of the first concept to the definition of contemporary modern management marketing strategy. It allows you to understand the role of marketing and place it in the context of the operation of enterprises, both historically and today. This section carries the explanation of one of the key concepts of transmitting the importance of this work, which is marketing - mix - kind of stem all marketing plans.Chapter two provides a comprehensive knowledge base containing an explanation of the advertising as a communication tool with customers. In proportional terms, it can be assumed that half the weight of this chapter is attributed to issues related to the theoretical aspects of advertising, such as the definition and historical background. After the presentation points explaining the essence of advertising, a further section focuses on issues relating to the methods of construction and operation of the advertising. Since advertising is one of the main problems of this research work, hence a lot of content explaining the issues, but in fact, advertising is and what qualities it has acquired.The third part of the work is devoted to the title concept of celebrity endorsement and on all issues related to the concept. It highlights the character of a famous person: its features, types of existing advertising rules of selecting a celebrity for advertising, as well as methods for their impact on the consumer. This section also gives the opportunity to explore the phenomenon, how they affect their image of society.The last module, is almost the essence of all work. It was divided into five smaller segments, each of which has the task to bring a confirmation of the thesis. The first part is characteristic of the company P4 Sp. Z oo: the history of the development, domains and objectives of the action. Then quoted is a description of its marketing strategy activities in marketing structures and their general definition. . It concerns both about the actions of ATL, what and BTL. Then these efforts directly translate to ongoing since 2012 multi celebrity communication

The Autoimmune pituitary inflammation

Autoimmune Hypophysitis (AH) is often refereed in the literature as lymphocytic pituitary inflammation. It is the most common form of rare, chronic inflammation states affecting this gland. In most cases it has autoimmune character. Symptoms of pituitary inflammation are mostly headaches, dysfunction of anterior and/or posterior pituitary lobe and visual disturbances. Diagnostics is extremely difficult and inflammation itself is probably diagnosed too rare. Autoimmune Hypophysitis coexist with other autoimmune endocrinopathies. The golden standard in Autoimmune Hypophysitis diagnosis is biopsy and magnetic resonance imaging (MRI) is also used. In relation to rare occurrence of the  Autoimmune Hypophysitis, varied clinical picture and lack of standardized research on large group of patients there are no described standards of conduct with those patients.Autoimmune Hypophysitis (AH) is often refereed in the literature as lymphocytic pituitary inflammation. It is the most common form of rare, chronic inflammation states affecting this gland. In most cases it has autoimmune character. Symptoms of pituitary inflammation are mostly headaches, dysfunction of anterior and/or posterior pituitary lobe and visual disturbances. Diagnostics is extremely difficult and inflammation itself is probably diagnosed too rare. Autoimmune Hypophysitis coexist with other autoimmune endocrinopathies. The golden standard in Autoimmune Hypophysitis diagnosis is biopsy and magnetic resonance imaging (MRI) is also used. In relation to rare occurrence of the Autoimmune Hypophysitis, varied clinical picture and lack of standardized research on large group of patients there are no described standards of conduct with those patients

Protocol of the study: the effectiveness of pleuran in the treatment of acute gastroenteritis in children—a randomised, placebo-controlled, double-blind trial (EPTAGE)

Introduction Acute gastroenteritis is one of the most common causes of children’s morbidity and mortality globally. Oral or intravenous rehydration was proven effective in reducing the mortality rates in acute gastroenteritis, although it does not affect the course of the disease. Attempts to identify new therapeutic methods effective in reducing the symptoms of diarrhoea are of interest. Pleuran’s potential immunomodulatory effect in acute gastrointestinal infection relies on the stimulation of innate immunity. The effectiveness of pleuran (β-(1,3/1,6)-d-glucan) administration to treat acute infectious diarrhoea remains unknown. This study evaluates the efficacy of pleuran in reducing diarrhoea duration and the severity of acute gastroenteritis symptoms in children.Methods and analysis Our study is a randomised, double-blind, placebo-controlled superiority trial with two parallel groups and a 1:1 allocation ratio. A total of 120 children aged 2–10 years hospitalised or requiring a visit to the emergency department because of acute gastroenteritis will be randomly assigned to receive either pleuran oral suspension in the experimental group or matching placebo in the control group. The primary outcome measure will be the duration of diarrhoea. We will analyse the results in both intention-to-treat and per-protocol approaches.Ethics and dissemination The Bioethics Committee of The Medical University of Warsaw approved the study protocol (approval number: KB/45/2018). Written informed consent of the patients’ caregivers participating in the study will be obligatory. The results of this study will be published in a medical journal, regardless of whether they confirm or deny the research hypothesis.Trial registration number NCT03988257; Pre-results

POSSIBILITY OF AL-CU COMPOSITE MANUFACTURING FROM FINE METAL FRACTIONS BY RECYCLING PROCESS

Plastic consolidation of highly fragmented materials is a cost-effective way to recover aluminum alloys. In this process, metal in the form of chips, powders, or ribbons omits the melting step that is typical for conventional scrap recycling; by that, it significantly reduces both energy expenses and material losses. By reducing the number of operations, the cost of labor and expenditures on environmental protection can be decreased. In addition, the solid bonding of metals in highly dispersed forms allows us to create heterogeneous structures that could be difficult to obtain in traditional processes. In the present study, the influence of the addition of Cu powder (99.7 wt.%) on the bonding quality of aluminum powder (99.7 wt.%) during hot extrusion is being examined. The examined materials contained aluminum powder with the addition of 5 wt.% of Cu powder. The mixture of these powders were cold compacted to produce an 80-mm-long charge for the extrusion process. Plastic consolidation was conducted at three different temperatures: 300°, 350°, and 400°C. As a result, rods 8 mm in diameter were obtained. Mechanical tests combined with microstructure observations and electrical conductivity tests were performed for the as-extruded materials