Branchenübergreifendes Benchmarking von variantenreichen Produktportfolios auf Basis von Produktstrukturen

Für die Messung von Prozessabläufen wie der Beschaffung (Supply Chain), der Arbeitsvorbereitung und der Produktion werden spezifische Unternehmenskennzahlen genutzt. Diese Key Performance Indicator (kurz: KPI) bilden häufig jedoch ausschließlich finanzielle Aspekte für eine unternehmensinterne Überwachung ab und berücksichtigen nicht den Entwicklungsprozess. Alternative Ansätze verwenden aus dem Expertenwissen der Mitarbeiter zusammengetragene Informationen, die durch ihre Subjektivität die Reproduzierbarkeit erschweren. In Abgrenzung zu bestehenden Konzepten wird in diesem Beitrag die Effizienz-Bewertung von variantenreichen Produktportfolios auf Basis der Produktstrukturen sämtlicher realisierter Erzeugnisvarianten beschrieben. [... aus Punkt 2

Counterfeit and substandard test of the antimalarial tablet Riamet® by means of Raman hyperspectral multicomponent analysis

The fight against counterfeit pharmaceuticals is a global issue of utmost importance, as failed medication results in millions of deaths every year. Particularly affected are antimalarial tablets. A very important issue is the identification of substandard tablets that do not contain the nominal amounts of the active pharmaceutical ingredient (API), and the differentiation between genuine products and products without any active ingredient or with a false active ingredient. This work presents a novel approach based on fiber-array based Raman hyperspectral imaging to qualify and quantify the antimalarial APIs lumefantrine and artemether directly and non-invasively in a tablet in a time-efficient way. The investigations were carried out with the antimalarial tablet Riamet® and self-made model tablets, which were used as examples of counterfeits and substandard. Partial least-squares regression modeling and density functional theory calculations were carried out for quantification of lumefantrine and artemether and for spectral band assignment. The most prominent differentiating vibrational signatures of the APIs were presented

Comprehensive Patent Data of the German Democratic Republic 1949-1990—Technical Report and Dataset Overview

This paper documents the generation and the content of the Comprehensive Patent Database (CPDB) of the German Democratic Republic (GDR) (1949-1990), Version 1.1, which is freely available at GESIS https://doi.org/10.7802/2423. The database contains all patents granted in the GDR and published by the Office of Inventions and Patents (AfEP, later: German Patent and Trade Mark Office/DPMA) in the period between 1 January 1939 (application before but granted in the GDR) and 29 June 2006 (application in but granted after the GDR). The core database covers the years 1950 to 1990 and contains 24 variables with manually cleaned and processed information on a total of 261,822 unique patents of the GDR. The data was collected and prepared for the purpose of research on innovation activity in the GDR