Enhanced optical alignment of a digital micro mirror device through Bayesian adaptive exploration

As the use of Digital Micro Mirror Devices (DMDs) becomes more prevalent in optics research, the ability to precisely locate the Fourier “footprint” of an image beam at the Fourier plane becomes a pressing need. In this approach, Bayesian adaptive exploration techniques were employed to characterize the size and position of the beam on a DMD located at the Fourier plane. It couples a Bayesian inference engine with an inquiry engine to implement the search. The inquiry engine explores the DMD by engaging mirrors and recording light intensity values based on the maximization of the expected information gain. Using the data collected from this exploration, the Bayesian inference engine updates the posterior probability describing the beam’s characteristics. The process is iterated until the beam is located to within the desired precision. This methodology not only locates the center and radius of the beam with remarkable precision but accomplishes the task in far less time than a brute force search. The employed approach has applications to system alignment for both Fourier processing and coded aperture design

Welfare versus punishment?: The careers of young offenders with a background in public care.

Young people with a background in public care are over-represented in the criminal justice system. The subject of the thesis concerns the relationship between these two systems. The main focus of this qualitative piece of research is an analysis of the cases of thirty young people who have had experience of both systems. Conducted on the site of a Welsh Social Services Youth Justice Team that - during the course of the fieldwork - was reconfigured as a Youth Offending Team, the research was guided by three related questions. Firstly, what was the nature of the relationship between the public care system and the criminal justice system? Secondly, how did such discourses as 'welfare' and 'punishment' influence what happened to young people with care backgrounds in the youth justice system? Thirdly, how did the youth justice reforms of the 1997-2001 Labour government impact on practice at ground level? These questions were addressed by a combination of methods: semi-structured interviews with young people, parents and practitioners; focus groups with professional staff; observation; and analysis of case files and other agency documents. The analysis identified a number of social and institutional processes that criminalised children in public care and accelerated their 'progress' through the criminal justice system

Road and bridge construction across gypsum karst in England

Gypsum karst problems in the Permian and Triassic sequences of England have caused difficult conditions for bridge and road construction. In Northern England, the Ripon Bypass crosses Permian strata affected by active gypsum karst and severe subsidence problems. Here, the initial borehole site investigation for the road was supplemented by resistivity tomography studies. The roadway was reinforced with two layers of tensile membrane material within the earth embankment. This will prevent dangerous catastrophic collapse, but will allow sagging to show where problems exist. The River Ure Bridge was constructed across an area of subsidence pipes filled with alluvial deposits. It was built with extra strength, larger than normal foundations. If one pier fails, the bridge is designed for adjacent arches to span the gap without collapse. The bridge piers are also fitted with electronic load monitoring to warn of failure. In the Midlands area of England, road construction over Triassic gypsum has required a phase of ground improvement on the Derby Southern Bypass. Here, the gypsum caps a hill where it was formerly mined; it dips through a karstic dissolution zone into an area of complete dissolution and collapse. The road and an associated flyover were built across these ground conditions. A major grouting program before the earthworks began treated the cavities in the mine workings and the cavernous margin of the gypsum mass. Within the karstic dissolution zone, gypsum blocks and cavities along the route were identified by conductivity and resistivity geophysical surveys, excavated and backfilled. In the areas of complete dissolution and collapse, the road foundation was strengthened with vibrated stone columns and a reinforced concrete road deck was used

Empathic and Self-Regulatory Processes Governing Doping Behavior

Evidence associating doping behavior with moral disengagement (MD) has accumulated over recent years. However, to date, research examining links between MD and doping has not considered key theoretically grounded influences and outcomes of MD. As such, there is a need for quantitative research in relevant populations that purposefully examines the explanatory pathways through which MD is thought to operate. Toward this end, the current study examined a conceptually grounded model of doping behavior that incorporated empathy, doping self-regulatory efficacy (SRE), doping MD, anticipated guilt and self-reported doping/doping susceptibility. Participants were specifically recruited to represent four key physical-activity contexts and consisted of team- (n = 195) and individual- (n = 169) sport athletes and hardcore- (n = 125) and corporate- (n = 121) gym exercisers representing both genders (nmale = 371; nfemale = 239); self-reported lifetime prevalence of doping across the sample was 13.6%. Each participant completed questionnaires assessing the aforementioned variables. Structural equation modeling indicated strong support for all study hypotheses. Specifically, we established: (a) empathy and doping SRE negatively predicted reported doping; (b) the predictive effects of empathy and doping SRE on reported doping were mediated by doping MD and anticipated guilt; (c) doping MD positively predicted reported doping; (d) the predictive effects of doping MD on reported doping were partially mediated by anticipated guilt. Substituting self-reported doping for doping susceptibility, multisample analyses then demonstrated these predictive effects were largely invariant between males and females and across the four physical-activity contexts represented. These findings extend current knowledge on a number of levels, and in doing so aid our understanding of key psychosocial processes that may govern doping behavior across key physical-activity contexts

Visual responses in the lateral geniculate evoked by Cx36-independent rod pathways

AbstractEmerging evidence indicates rods can communicate with retinal ganglion cells (RGCs) via pathways that do not involve gap-junctions. Here we investigated the significance of such pathways for central visual responses, using mice lacking a key gap junction protein (Cx36−/−) and carrying a mutation that disrupts cone phototransduction (Gnat2cpfl3). Electrophysiological recordings spanning the lateral geniculate revealed rod-mediated ON and OFF visual responses in virtually every cell from all major anatomical sub-compartments of this nucleus. Hence, we demonstrate that one or more classes of RGC receive input from Cx36-independent rod pathways and drive extensive ON and OFF responses across the visual thalamus

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

© 2008 Henry et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Measurement resources for dissemination and implementation research in health

BACKGROUND: A 2-day consensus working meeting, hosted by the United States National Institutes of Health and the Veterans Administration, focused on issues related to dissemination and implementation (D&I) research in measurement and reporting. Meeting participants included 23 researchers, practitioners, and decision makers from the USA and Canada who concluded that the field would greatly benefit from measurement resources to enhance the ease, harmonization, and rigor of D&I evaluation efforts. This paper describes the findings from an environmental scan and literature review of resources for D&I measures. FINDINGS: We identified a total of 17 resources, including four web-based repositories and 12 static reviews or tools that attempted to synthesize and evaluate existing measures for D&I research. Thirteen resources came from the health discipline, and 11 were populated from database reviews. Ten focused on quantitative measures, and all were generated as a resource for researchers. Fourteen were organized according to an established D&I theory or framework, with the number of constructs and measures ranging from 1 to more than 450. Measure metadata was quite variable with only six providing information on the psychometric properties of measures. CONCLUSIONS: Additional guidance on the development and use of measures are needed. A number of approaches, resources, and critical areas for future work are discussed. Researchers and stakeholders are encouraged to take advantage of a number of funding mechanisms supporting this type of work. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13012-016-0401-y) contains supplementary material, which is available to authorized users