Projecting the Past: Ancient Rome, Cinema and History

Brought vividly to life on screen, the myth of ancient Rome resonates through modern popular culture. Projecting the Past examines how the cinematic traditions of Hollywood and Italy have resurrected ancient Rome to address the concerns of the present. The book engages contemporary debates about the nature of the classical tradition, definitions of history, and the place of the past in historical film

UMA COVID-19_News_President Updates_A Message from President Wyke: UMA’s Safe Return Plan

Screenshot of University of Maine at Augusta\u27s news webpage with a communication from President Rebecca M. Wyke regarding the return to campus for the 2020 Fall Semester

UMA COVID-19_News_President Updates_UMA Preparatons and Planning for COVID-19

Screenshot of University of Maine at Augusta\u27s news webpage with a message from University of Maine at Augusta President Rebecca M. Wyke

UMA COVID-19_News_President Updates_Update from President Wyke on UMA’s Efforts Regarding COVID-19, March 19th

Screenshot of University of Maine at Augusta\u27s news webpage with a communication from President Rebecca M. Wyke regarding steps announced to take student support and other services online and asking the majority of employees to telecommute from home via our distance education network and capabilities

UMA COVID-19_News_President Updates_UMA is Ready for Students to Return from Spring Break

Screenshot of University of Maine at Augusta\u27s news webpage with a communication from President Rebecca M. Wyke regarding students returning from an extended Spring Beak

UMA COVID-19_News_President Updates_UMA’s Efforts Regarding COVID-19, March 16th

Screenshot of University of Maine at Augusta\u27s news webpage with a communication from President Rebecca M. Wyke regarding precautions the University took to slow the spread of COVID-19 and protect our community

UMA COVID-19_News_President Updates_Important Information for UMA Employees: UMS Workplace Policies and Guidance Regarding COVID-19

Screenshot of University of Maine at Augusta\u27s news webpage with a communication from President Rebecca M. Wyke regarding University of Maine System issued policies and guidelines regarding COVID-19

UMA COVID-19_News_President Updates_Decisions Regarding UMA’s 2020 Commencement Exercises

Screenshot of University of Maine at Augusta\u27s news webpage with a communication from President Rebecca M. Wyke regarding the postponement of commencement exercises to October 3, 2020 due to the COVID-19 pandemic

Cellular signalling pathways involved in muscle atrophy in cancer cachexia

Cancer cachexia encompases severe weight loss, characterised by the debilitating atrophy of adipose and skeletal muscle mass. Skeletal muscle proteolysis in cancer cachexia is mediated by a sulphated glycoprotein with a relative molecular mass of 24kDa, termed Proteolysis-Inducing Factor (PIF). PIF induced a significant increase in protein degradation, peaking at 4.2nM PIF (p<0.001), ‘chymotrypsin-like’ activity of the proteasome (p<0.001) and increased expression of components of the ATP-ubiquitin dependent proteolytic pathway. This was attenuated in vitro by pre-incubation with the PKC inhibitor calphostin C (100µM) and NF-kB the inhibitors SN50 (18µM), curcumin (50µM) and resveratrol (30µM), 2 hours prior to the addition of PIF. In vivo studies found the IKK inhibitor resveratrol (1mg/kg) to be successful in attenuating protein degradation (p<0.001) and upregulation of ubiquitin-dependent proteolysis in MAC16 tumour bearing mice. C2C12 myoblasts transfected with mutant IkBα and PKCα inserts did not elicit a PIF-induced response, suggesting the importance of the transcription factor NF-kB and PKC  involvement in PIF signal transduction. 15(S)-HETE acts as an intracellular mediator of PIF and exerts an effect through the activation of PKC and subsequently IKK, which phosphorylates IkBα and allows NF-kB to migrate to the nucleus. This effect was negated with the PKC inhibitor calphostin C (300nM). A commercially produced PIF receptor antibody was raised in rabbits immunised with a peptide containing the partial N-terminal sequence of the PIF receptor. The PIF receptor antibody was successful in attenuating the PIF-induced increase in skeletal muscle catabolism and protein degradation in vitro at 10µg/ml (p<0.001) and 3.47mg/kg in vivo (p<0.001). The data suggest great potential in the development of this antibody as a therapy against cancer cachexia