SPATIAL HETEROGENEITY, MOBILITY AND ACCESS: THE CASE OF RANGE MANAGEMENT IN THE SAHEL

In this paper, we develop and calibrate a spatial and intertemporal bioeconomic model of livestock production to the West African Sahel region. The model is then used to investigate the effects of land heterogeneity, range scale, and access rights on long term management of rangeland in the Sahel.Livestock Production/Industries,

Summary of DSN (Deep Space Network) reimbursable launch support

The Deep Space Network is providing ground support to space agencies of foreign governments as well as to NASA and other agencies of the Federal government which are involved in space activities. DSN funding for support of missions other than NASA are on either a cooperative or a reimbursable basis. Cooperative funding and support are accomplished in the same manner as NASA sponsored missions. Reimbursable launch funding and support methods are described

Inactivation of Mandelate Racemase by 3-Hydroxypyruvate Reveals a Potential Mechanistic Link between Enzyme Superfamilies

Mandelate racemase (MR), a member of the enolase superfamily, catalyzes the Mg2+-dependent interconversion of the enantiomers of mandelate. Several α-keto acids are modest competitive inhibitors of MR [e.g., mesoxalate (Ki = 1.8 ± 0.3 mM) and 3-fluoropyruvate (Ki = 1.3 ± 0.1 mM)], but, surprisingly, 3-hydroxypyruvate (3-HP) is an irreversible, time-dependent inhibitor (kinact/KI = 83 ± 8 M–1 s–1). Protection from inactivation by the competitive inhibitor benzohydroxamate, trypsinolysis and electrospray ionization tandem mass spectrometry analyses, and X-ray crystallographic studies reveal that 3-HP undergoes Schiff-base formation with Lys 166 at the active site, followed by formation of an aldehyde/enol(ate) adduct. Such a reaction is unprecedented in the enolase superfamily and may be a relic of an activity possessed by a promiscuous progenitor enzyme. The ability of MR to form and deprotonate a Schiff-base intermediate furnishes a previously unrecognized mechanistic link to other α/β-barrel enzymes utilizing Schiff-base chemistry and is in accord with the sequence- and structure-based hypothesis that members of the metal-dependent enolase superfamily and the Schiff-base-forming N-acetylneuraminate lyase superfamily and aldolases share a common ancestor

The Cantor Set, Trees, and Compact Metric Spaces

The Cantor Set is a famous topological set developed from an infinite process of starting with the interval [0,1] and, at each iteration, removing the middle third of the intervals remaining. Our goal is to determine some of the properties of this unintuitive set and to show that it is homeomorphic to any general compact metric space with similar properties. To do so, we show that the Cantor Set is topologically equivalent to a tree, a more familiar structure, and use this fact to establish a homeomorphism to the general compact metric space

Being Aristotelian: Using Virtue Ethics in an Applied Media Ethics Course

This essay explores the tendency of undergraduate media ethics students to do what Bernard Gert calls “morality by slogans” and their tendency to misuse Aristotle’s golden mean slogan. While not solving the dilemma of morality by slogans, the essay suggests some ways of rectifying the misuse of the golden mean and encouraging its more authentic application

The Herts and Minds study: feasibility of a randomised controlled trial of Mentalizationbased Treatment versus usual care to support the wellbeing of children in foster care

© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Background: There is a lack of well-designed randomized controlled trials (RCTs) to investigate the efficacy of psychological therapies for children in foster care with emotional and behavioural difficulties. Mentalization-based therapy (MBT) focuses on supporting the carer-child relationship by promoting reflective capacity. This study examined the feasibility and acceptability of an RCT of MBT, delivered in a family-format, for children who are in foster care in the UK. Method: Herts and Minds was a phase II, blinded feasibility RCT with follow-up of at 12 and 24 weeks post-randomisation. Participants were children (age 5-16) in foster care referred to a targeted mental health service, who had some level of difficulty as identified by the Strengths and Difficulties Questionnaire (SDQ). Aims were to assess: the feasibility of recruitment processes and study uptake; capacity to train mental health practitioners to deliver MBT to an acceptable level of treatment integrity; establish acceptability and credibility of MBT as an intervention for children in foster care; establish feasibility and acceptability to participants of conducting an RCT; and estimate the likely treatment efficacy effect size. Participants were randomly allocated to either MBT (n = 15) or Usual Clinical Care (UCC) (n = 21) individually or in sibling groups. A range of qualitative and quantitative data was gathered to assess feasibility. Results: Feasibility was established with regard to: capacity to recruit participants to a study; capacity to train mental health practitioners to deliver MBT to an acceptable level of treatment integrity; acceptability and credibility of MBT; and feasibility and acceptability to participants of conducting an RCT. A number of issues made it difficult to estimate a likely treatment efficacy effect size. Conclusion: With modifications, it is feasible to run an RCT of MBT for children in foster care. Both the therapy and research design were acceptable to participants, but modifications may be needed regarding both the timing of assessments and the identification of appropriate primary outcome measures. Given the lack of evidenced based therapies for this population, such a trial would be a significant contribution to the field. Findings may be useful for other groups planning clinical trials of psychological therapies for children in foster care. Trial registration: ISRCTN 90349442. The trial was retrospectively registered on 6 May 2016.Peer reviewedFinal Published versio

True Confessions of The New York Times: Making Moral Meaning from the Discourse of Flawed Iraq Coverage

On the morning of May 26, 2004, New York Times readers found a note from the paper’s editors on Page A10. The headline read “From the Editors – The Times and Iraq,” and the 1,000-word article that followed served as a disclosure that the Times had failed in its duty of both aggressive information gathering and careful reporting with a critical eye. Response to the note was fast and widespread as newspeople across the country commented on the paper’s public admission of its flawed coverage. The editors’ note, together with the responses it generated, provides a glimpse into the state of American journalism and the way those enmeshed in it understand and expect the practice to operate. Beyond serving a descriptive purpose, however, the texts of the note and the responses can be used to start a discourse in the normative realm, to offer suggestions for how our understanding of journalism perhaps ought to change to better reflect the reality of what is truly a human institution. This paper provides both a descriptive and normative analysis of two themes that emerge within the New York Times editors’ note and the subsequent responses that it prompted. First, the failure at the Times seems to add another notch to the credibility crisis in which U.S. journalism currently finds itself. The disclosure and responses reveal new concerns about the press and its performance. While the first trend illuminates problems, the second illustrates progress by demonstrating that the press, or at least one of its most important organizations, recognizes that it is a fallible, human institution and one that should – is perhaps even morally required to – communicate with is audiences about the process of newstelling. It is through precedent-setting cases like this one that journalists can step back, take a look at their practice, and then continue moving forward in a landscape that is constantly in flux