Robust Tickets Can Transfer Better: Drawing More Transferable Subnetworks in Transfer Learning

Transfer learning leverages feature representations of deep neural networks (DNNs) pretrained on source tasks with rich data to empower effective finetuning on downstream tasks. However, the pretrained models are often prohibitively large for delivering generalizable representations, which limits their deployment on edge devices with constrained resources. To close this gap, we propose a new transfer learning pipeline, which leverages our finding that robust tickets can transfer better, i.e., subnetworks drawn with properly induced adversarial robustness can win better transferability over vanilla lottery ticket subnetworks. Extensive experiments and ablation studies validate that our proposed transfer learning pipeline can achieve enhanced accuracy-sparsity trade-offs across both diverse downstream tasks and sparsity patterns, further enriching the lottery ticket hypothesis.Comment: Accepted by DAC 202

NetDistiller: Empowering Tiny Deep Learning via In-Situ Distillation

Boosting the task accuracy of tiny neural networks (TNNs) has become a fundamental challenge for enabling the deployments of TNNs on edge devices which are constrained by strict limitations in terms of memory, computation, bandwidth, and power supply. To this end, we propose a framework called NetDistiller to boost the achievable accuracy of TNNs by treating them as sub-networks of a weight-sharing teacher constructed by expanding the number of channels of the TNN. Specifically, the target TNN model is jointly trained with the weight-sharing teacher model via (1) gradient surgery to tackle the gradient conflicts between them and (2) uncertainty-aware distillation to mitigate the overfitting of the teacher model. Extensive experiments across diverse tasks validate NetDistiller's effectiveness in boosting TNNs' achievable accuracy over state-of-the-art methods. Our code is available at https://github.com/GATECH-EIC/NetDistiller

Castling-ViT: Compressing Self-Attention via Switching Towards Linear-Angular Attention During Vision Transformer Inference

Vision Transformers (ViTs) have shown impressive performance but still require a high computation cost as compared to convolutional neural networks (CNNs), one reason is that ViTs' attention measures global similarities and thus has a quadratic complexity with the number of input tokens. Existing efficient ViTs adopt local attention (e.g., Swin) or linear attention (e.g., Performer), which sacrifice ViTs' capabilities of capturing either global or local context. In this work, we ask an important research question: Can ViTs learn both global and local context while being more efficient during inference? To this end, we propose a framework called Castling-ViT, which trains ViTs using both linear-angular attention and masked softmax-based quadratic attention, but then switches to having only linear angular attention during ViT inference. Our Castling-ViT leverages angular kernels to measure the similarities between queries and keys via spectral angles. And we further simplify it with two techniques: (1) a novel linear-angular attention mechanism: we decompose the angular kernels into linear terms and high-order residuals, and only keep the linear terms; and (2) we adopt two parameterized modules to approximate high-order residuals: a depthwise convolution and an auxiliary masked softmax attention to help learn both global and local information, where the masks for softmax attention are regularized to gradually become zeros and thus incur no overhead during ViT inference. Extensive experiments and ablation studies on three tasks consistently validate the effectiveness of the proposed Castling-ViT, e.g., achieving up to a 1.8% higher accuracy or 40% MACs reduction on ImageNet classification and 1.2 higher mAP on COCO detection under comparable FLOPs, as compared to ViTs with vanilla softmax-based attentions.Comment: CVPR 202

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Social Relationships, Inflammation, and Cognitive Function among Older Mexican Americans

Social relationships may be a protective factor for cognitive decline. Elevated levels of inflammatory biomarkers are associated with cognitive decline. We aim to estimate the effect of social relationships (family support and local ties in particular) on cognitive function (measured by Modified Mini Mental State Exam and the Spanish and English Verbal Learning Test) and investigate whether the elevated level of inflammatory biomarkers mediates this effect among 1,374 Hispanic participants from the Sacramento Area Latino Study on Aging (1998–2007). The total effects of social relationship measures on follow-up cognitive functions were assessed. A mediation analysis (potential outcome framework) was applied to decompose direct and indirect effects. The results were compatible with a protective effect of family support on cognitive function with a larger effect estimated in earlier follow-up time. The null 95% CI of indirect effect estimates suggest there is limited mediation through inflammatory biomarkers within this study sample