Remote Sensing Rock Mechanics and Earthquake Thermal Infrared Anomalies

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Down-regulation of NRIP1 alleviates pyroptosis in human lens epithelial cells exposed to hydrogen peroxide by inhibiting NF-κB activation

Purpose: To investigate the role of nuclear receptor-interacting protein 1 (NRIP1) in oxidative stressinduced apoptosis and pyroptosis in cataract disease.Methods: Human lens epithelial cells (HLE-B3 cells) were exposed to hydrogen peroxide (H2O2). NRIP1 expression in hydrogen peroxide (H2O2)-treated HLE-B3 cells was determined by western blotting and quantitative reverse transcription polymerase chain reaction (qRT-PCR). CCK8 and EdU staining were used to assess cell viability. Flow cytometry and western blotting were used to assess pyroptosis.Results: NRIP1 was significantly up-regulated in HLE-B3 cells post-H2O2 incubation (p < 0.01). Hydrogen peroxide incubation reduced cell viability and proliferation of HLE-B3 cells, while NRIP1 knockdown enhanced cell viability and proliferation. NRIP1 silencing attenuated the H2O2-induced increase in NLRP3, N-terminal domain of gasdermin D, caspase-1, interleukin (IL)-1β, and IL-18 in HLEB3 cells, but suppressed the pyroptosis of H2O2-treated HLE-B3 cells. Hydrogen peroxide incubation down-regulated protein expression of cytoplasmic NF-κB and up-regulated nuclear NF-κB, while the expression of cytoplasmic NF-κB was increased and nuclear NF-κB was decreased in HLE-B3 cells by HLE-B3 interference.Conclusion: NRIP1 down-regulation represses apoptosis and pyroptosis of H2O2-treated human lens epithelial cells by inhibiting NF-κB activation, thus, providing a potential strategy to treat cataract disease

Progress in Analysis to Remote Sensed Thermal Abnormity with Fault Activity and Seismogenic Process

Research to the remote sensed thermal abnormity with fault activity and seismogenic process is a vital topic of the Earth observation and remote sensing application. It is presented that a systematic review on the international researches on the topic during the past 30 years, in the respects of remote sensing data applications, anomaly analysis methods, and mechanism understanding. Firstly, the outlines of remote sensing data applications are given including infrared brightness temperature, microwave brightness temperature, outgoing longwave radiation, and assimilated data from multiple earth observations. Secondly, three development phases are summarized as qualitative analysis based on visual interpretation, quantitative analysis based on image processing, and multi-parameter spatio-temporal correlation analysis. Thirdly, the theoretical hypotheses presented for the mechanism understanding are introduced including earth degassing, stress-induced heat, crustal rock battery conversion, latent heat release due to radon decay as well as multi-spheres coupling effect. Finally, three key directions of future research on this topic are proposed:anomaly recognizing by remote sensing monitoring and data analysis for typical tectonic activity areas; anomaly mechanism understanding based on earthquake-related earth system responses; spatio-temporal correlation analysis of air-based, space-based and ground-based stereoscopic observations

A Deviation-Time-Space-Thermal (DTS-T) Method for Global Earth Observation System of Systems (GEOSS)-Based Earthquake Anomaly Recognition: Criterions and Quantify Indices

The particular process of LCA (Lithosphere-Coversphere-Atmosphere) coupling referring to local tectonic structures and coversphere conditions is very important for understanding seismic anomaly from GEOSS (Global Earth Observation System of Systems). The LCA coupling based multiple-parameters analysis should be the foundation for earthquake prewarning. Three improved criterions: deviation notable enough, time quasi-synchronism, and space geo-adjacency, plus their quantify indices are defined for earthquake anomaly recognition, and applied to thermal parameters as a DTS-T (Deviation-Time-Space-Thermal) method. A normalized reliability index is preliminarily defined considering three quantify indices for deviation-time-space criterions. As an example, the DTS-T method is applied to the Ms 7.1 Yushu earthquake of 14 April 2010 in China. Furthermore, combining with the previous analysis of six recent significant earthquakes in the world, the statistical results regarding effective parameters, the occurrence of anomaly before the main shocks and a reliability index for each earthquake are introduced. It shows that the DTS-T method is reasonable and can be applied for routine monitoring and prewarning in the tectonic seismicity region

The Economic and Health Impacts of Subway Construction: Evidence from Beijing

Final ReportThis project aims to understand the large-scale transport infrastructure in the context of subway expansion in Beijing on traffic congestion, air pollution and ultimately on the wellbeing of the residents. The analysis produces estimates of the benefits from congestion relief and air quality from subway expansion and compare them with other transportation policies such as driving restriction and congestion pricing through their impacts on the housing market in Beijing.U.S. Department of Transportation 69A355174711