Point-contact tunneling spectroscopy measurement of Cux_xTiSe2_2: disorder-enhanced Coulomb effects

We performed point-contact spectroscopy tunneling measurements on Cu$_x$TiSe$_2$ bulk with $x=0.02$ and $0.06$ at temperatures ranging from $T=4-40$ K and observe a suppression in the density of states around zero-bias that we attribute to enhanced Coulomb interactions due to disorder. We find that the correlation gap associated with this suppression is related to the zero-temperature resistivity. We use our results to estimate the disorder-free transition temperature and find that the clean limit $T_{c0}$ is close to the experimentally observed $T_c$.Comment: 4 pages, 4 figure

Confining Flux Tubes in a Current Algebra Approach

We describe flux tubes and their interactions in a low energy sigma model induced by $SU({N_f}) \rightarrow SO({N_f})$ flavor symmetry breaking in $SO(N_c)$ QCD. Unlike standard QCD, this model allows gauge confinement to manifest itself in the low energy theory, which has unscreened spinor color sources and global $Z_2$ flux tubes. We construct the flux tubes and show how they mediate the confinement of spinor sources. We further examine the flux tubes' quantum stability, spectrum and interactions. We find that flux tubes are Alice strings, despite ambiguities in defining parallel transport. Furthermore, twisted loops of flux tube support skyrmion number, just as gauged Alice strings form loops that support monopole charge. This model, while phenomenologically nonviable, thus affords a perspective on both the dynamics of confinement and on subtleties which arise for global Alice strings.Comment: 29 pages (REVTEX) plus 6 figures, two corrections in the final section and added reference

Charge Violation and Alice Behavior in Global and Textured Strings

Spontaneous breaking of global symmetries can produce ``Alice'' strings: line defects which make unbroken symmetries multivalued, induce apparent charge violation via Aharonov-Bohm interactions, and form point defects when twisted into loops. We demonstrate this behavior for both divergent and textured global Alice strings. Both adiabatically scatter charged particles via effective Wilson lines. For textured Alice strings, such Wilson lines occur at all radii, and are multivalued only inside the string. This produces measurable effects, including path-dependent charge violation.Comment: 32 pages, 2 epsfigs, Revte

New Extinction and Mass Estimates from Optical Photometry of the Very Low Mass Brown Dwarf Companion CT Chamaeleontis B with the Magellan AO System

We used the Magellan adaptive optics (MagAO) system and its VisAO CCD camera to image the young low mass brown dwarf companion CT Chamaeleontis B for the first time at visible wavelengths. We detect it at r', i', z', and Ys. With our new photometry and Teff~2500 K derived from the shape its K-band spectrum, we find that CT Cha B has Av = 3.4+/-1.1 mag, and a mass of 14-24 Mj according to the DUSTY evolutionary tracks and its 1-5 Myr age. The overluminosity of our r' detection indicates that the companion has significant Halpha emission and a mass accretion rate ~6*10^-10 Msun/yr, similar to some substellar companions. Proper motion analysis shows that another point source within 2" of CT Cha A is not physical. This paper demonstrates how visible wavelength AO photometry (r', i', z', Ys) allows for a better estimate of extinction, luminosity, and mass accretion rate of young substellar companions.Comment: Accepted for publication in ApJ; 6 figure

New Extinction and Mass Estimates of the Low-mass Companion 1RXS 1609 B with the Magellan AO System: Evidence of an Inclined Dust Disk

We used the Magellan adaptive optics system to image the 11 Myr substellar companion 1RXS 1609 B at the bluest wavelengths to date (z' and Ys). Comparison with synthetic spectra yields a higher temperature than previous studies of $T_\mathrm{eff}=2000\pm100\mathrm{K}$ and significant dust extinction of $A_V=4.5^{+0.5}_{-0.7}$ mag. Mass estimates based on the DUSTY tracks gives 0.012-0.015 Msun, making the companion likely a low-mass brown dwarf surrounded by a dusty disk. Our study suggests that 1RXS 1609 B is one of the 25% of Upper Scorpius low-mass members harboring disks, and it may have formed like a star and not a planet out at 320 AU.Comment: 5 pages, 4 figures; accepted to ApJ

Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells.

Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renewal of mammalian cells. With site-specific integration for gene correction in cellular therapeutics, use of the OCT4 promoter may have advantages when expressing a suicide gene if pluripotency remains. However, the human OCT4 promoter region is 4 kb in size, limiting the capacity of therapeutic genes and other regulatory components for viral vectors, and decreasing the efficiency of homologous recombination. The purpose of this investigation was to characterize the functionality of a novel 967bp OCT4-short response element during pluripotency and to examine the OCT4 titer-dependent response during differentiation to human derivatives not expressing OCT4. Our findings demonstrate that the OCT4-short response element is active in pluripotency and this activity is in high correlation with transgene expression in vitro, and the OCT4-short response element is inactivated when pluripotent cells differentiate. These studies demonstrate that this shortened OCT4 regulatory element is functional and may be useful as part of an optimized safety component in a site-specific gene transferring system that could be used as an efficient and clinically applicable safety platform for gene transfer in cellular therapeutics

Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity

BACKGROUND: Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body. Signaling centers release morphogens that determine regional growth and tissue identity by regulating regional expression of transcription factors. Research on mouse cortex has identified several candidate morphogens that affect anteroposterior or mediolateral cortical regionalization as well as mitogenesis. Inbred strains of laboratory mice can be exploited to study cortical area map formation if there are significant phenotypic differences with which to correlate gene polymorphism or expression data. Here we describe differences in the cortical area map of two commonly used inbred strains of laboratory mice, C57BL/6J and DBA/2J. Complete cortical hemispheres from adult mice were dissected and stained for the cytochrome oxidase enzyme in order to measure histochemically defined cortical areas. RESULTS: C57BL/6J has the larger neocortex, relatively larger primary visual cortex (V1), but relatively smaller posterior medial barrel subfield of the primary somatosensory cortex (PMBSF). The sample of C57BL/6J and DBA/2J mice can be discriminated with 90% accuracy on the basis of these three size dimensions. CONCLUSION: C57BL/6J and DBA/2J have markedly different cortical area maps, suggesting that inbred strains harbor enough phenotypic variation to encourage a forward genetic approach to understanding cortical development, complementing other approaches