Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10-11 to 5.0 × 10-21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10-6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation

On incentivizing caching for P2P-VoD systems

10.1109/INFCOMW.2012.6193481Proceedings - IEEE INFOCOM164-169PINF

A game theoretic analysis on incentive mechanisms for wireless ad hoc VoD systems

2012 10th International Symposium on Modeling and Optimization in Mobile, Ad Hoc and Wireless Networks, WiOpt 2012177-18

Distributed caching via rewarding: An incentive scheme design in p2p-vod systems

10.1109/TPDS.2013.94IEEE Transactions on Parallel and Distributed Systems253612-621ITDS

On incentivizing upload capacity in P2P-VoD systems: Design, analysis and evaluation

10.1016/j.comnet.2013.02.016Computer Networks5771674-1688CNET

Gas separations using ceramic membranes

Alcoa's commercial membrane with 40[Angstrom] pore diameter has been identified as one of the potential candidates for high temperature gas separations. This asymmetric multiple layer membrane have been well characterized and evaluated. It has excellent thermal stability and acceptably hydrothermal stability at [approximately]650[degree]C or above. Gas separations with this membrane follow Knudsen diffusion. Its selectivity is suitable for bulk separations, or for reduction/elimination of H[sub 2]S and NH[sub 3] via selective removal of hydrogen. An improved separation efficiency with this membrane is highly desirable for applications involving hydrogen separation, and the removal of trace contaminants, such as H[sub 2]S and NH[sub 3]. One of the effective avenues in improving the efficiency of the existing membrane is to narrow its pore size through surface modifications. Thus membranes with a smaller pore size can be readily available through minor modifications of the existing commercial product. In this paper focus is on the morphological characterization and performance evaluation of hydrogen-selective and zeolitic membranes developed from existing commercial membranes

Developmental transcriptome of resting cell formation in Mycobacterium smegmatis

10.1186/s12864-016-3190-4BMC Genomics17183