1,549 research outputs found
Cost‐effectiveness analysis of additional docetaxel for metastatic hormone‐sensitive prostate cancer treated with androgen‐deprivation therapy from a Chinese perspective
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139091/1/ecc12505_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139091/2/ecc12505.pd
Silicon Carbide-Based Hydrogen and Hydrocarbon Gas Detection
Hydrogen and hydrocarbon detection in aeronautical applications is important for reasons of safety and emissions control. The use of silicon carbide as a semiconductor in a metal-semiconductor or metal-insulator-semiconductor structure opens opportunities to measure hydrogen and hydrocarbons in high temperature environments beyond the capabilities of silicon-based devices. The purpose of this paper is to explore the response and stability of Pd-SiC Schottky diodes as gas sensors in the temperature range from 100 to 400 C. The effect of heat treating on the diode properties as measured at 100 C is explored. Subsequent operation at 400 C demonstrates the diodes' sensitivity to hydrogen and hydrocarbons. It is concluded that the Pd-SiC Schottky diode has potential as a hydrogen and hydrocarbon sensor over a wide range of temperatures but further studies are necessary to determine the diodes' long term stability
Improved antitumor response to isolated limb perfusion with tumor necrosis factor after upregulation of endothelial monocyte-activating polypeptide II in soft tissue sarcoma
BACKGROUND: Experiments with tumor necrosis factor alpha (TNF) in rodents
have shown that a high dose can lead to hemorrhagic necrosis in tumors.
Endothelial monocyte-activating polypeptide II (EMAP-II) is a novel
tumor-derived cytokine, and its expression increases the TNF-1 receptor on
tumor endothelium, enhances the induction of tissue factor on tumor
endothelial cells, and has an antiangiogenic effect. It has recently been
shown that in vivo sensitivity of tumor vasculature to TNF is determined
by tumor production of EMAP-II. METHODS: We measured the level of EMAP-II
in a TNF-resistant soft tissue sarcoma. We subsequently
stabile-transfected this cell line with a retroviral construct containing
the EMAP gene. In an extremity perfusion model in tumor-bearing rats, we
measured response rates to TNF therapy. RESULTS: Functional EMAP-II
production was increased after this transfection. Immunostaining of
paraffin-embedded tumor tissue sections in rats showed an overexpression
of human EMAP-II. Results of the TNF perfusions in rats suggest that this
tumor is more sensitive to TNF therapy. CONCLUSIONS: EMAP-II is produced
in various levels. One can increase the sensitivity of tumor for TNF
therapy in vivo by upregulating the EMAP-II production. This result leaves
an opportunity for enhanced TNF response of tumors in future settings
Approach to equilibrium for a class of random quantum models of infinite range
We consider random generalizations of a quantum model of infinite range
introduced by Emch and Radin. The generalization allows a neat extension from
the class of absolutely summable lattice potentials to the optimal class
of square summable potentials first considered by Khanin and Sinai and
generalised by van Enter and van Hemmen. The approach to equilibrium in the
case of a Gaussian distribution is proved to be faster than for a Bernoulli
distribution for both short-range and long-range lattice potentials. While
exponential decay to equilibrium is excluded in the nonrandom case, it is
proved to occur for both short and long range potentials for Gaussian
distributions, and for potentials of class in the Bernoulli case. Open
problems are discussed.Comment: 10 pages, no figures. This last version, to appear in J. Stat. Phys.,
corrects some minor errors and includes additional references and comments on
the relation to experiment
Lattice Study of the Massive Schwinger Model with a term under L\"uscher's "Admissibility" condition
We present a numerical study of the massive two-flavor QED in two dimensions
with the gauge action proposed by L\"uscher, which allows only ``admissible''
gauge fields. We find that the admissibility condition does not allow any
topology changes by the local updation in Hybrid Monte Carlo algorithm so that
the configurations in each topological sector can be generated separately. By
developing a new method to sum over different topological sectors, we
investigate vacuum effects. Combining with domain-wall fermion action,
we obtain the fermion mass dependence and dependence of the meson
masses, which are consistent with the analytic results by mass perturbation in
the continuum theory.Comment: 3 pages, Lattice2003(chiral
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