Analysis of Vehicle Use Patterns during Military Field Exercises to Identify Potential Roads

Military training is an intensive land use and can cause negative environmental effects. Many studies conducted under Integrated Training Area Management (ITAM) for quantifying the impact resulted from the military training exercise found that off-road vehicular activities during training exercises cause the major impact to the training land. Vehicle land use patterns at a certain location affect the impact severity: concentrated and repeated traffic create more serious damage to the land compared to the dispersed offroad vehicle movements. Those areas heavily disturbed by off-road traffic may require a longer period of time or special treatments for the land to return to its pre-disturbed status. Based on the impact severity and the shape of the disturbed area, some areas can be considered as potential roads, defined as the roads newly formed by concentrated offroad traffic during the military training exercises, or the roads currently exist but have not been mapped. Potential roads need to be rehabilitated, have traffic dispersed to return the land to its natural status, or to be included in the established road construction and maintenance programs. As Global Positioning System (GPS) has been used for monitoring vehicles\u27 activities during military training exercises; it enables the analysis of vehicle movement patterns. The vehicle movement patterns are characterized as the percentage of vehicle travel every day, vehicles\u27 on and off road travel, the frequencies of vehicle\u27s off-road velocity and turning radius. GPS vehicle tracking data collected during an eight-day reconnaissance training exercises in Yakima Training Center (YTC) in October 2001 were analyzed for vehicle movement patterns. Comparison of the on-road and off-road movement patterns indicates that potential roads may exist on the locations where the concentrated traffic or a high speed movement occurred. Based on the analysis of the movement patterns, factors were extracted to characterize the special movement patterns that indicate the vehicles moved on a potential road. The YTC was divided into small study units, and a multicriteria method was developed to determine if a study unit is a portion of a potential road. The multicriteria method was evaluated by comparing the predictions to the site visit results on 34 selected road segments that met different criteria levels. Results show that locations met higher criteria levels have higher possibilities to be roads: the location met all five criteria has an approximately 91% possibility for road existence; those met four criteria has an approximately 55% possibility; and for those met criteria level two or three, there is an approximately 14% probability for road existence. The analysis of updated off-road shows the percentage of vehicle off-road movement drops from 20.0% to 15.8% after excluding the potential road moving data. As an alternative method, a neural network approach for identifying the potential roads was introduced and compared to the multicriteria method. The neural network method obtained an approximately 85% accuracy when tested by on-road grids, successfully identified the high-way segment as road, and predicted approximately 31% off-road grids as potential road grids. Results show that the neural network method, although emphasized in factors different from the multicriteria method, has approximately 78% accuracy for identifying the potential road locations. The prediction from the neural network method was found highly correlated to the one of the criterion: vehicles travel in different directions. Simplified methods were also developed to identify potential roads by investigating the GPS point density, vehicle velocity, and the number of passes within a study unit. A simple linear relationship was found between the number of passes and the possibility for road existence. Although using vehicle velocity for identifying the potential roads may not be the best choose, velocity is still considered as one of the most important features to characterize vehicle movements and to locate special movement patterns. Considering the discrete situation in the predicted potential road areas, a kernel smoothing technique was introduced and applied to smooth the results to improve the continuity of the potential roads. The application found the kernel smoothing technique was able to obtain continuous potential road grids by selecting reasonable bandwidth

Study on the mechanism of the overall evolution of Chinese students’ physical health testing system

Physical health test plays an important role in students’ physical health, since the reform and opening up, Chinese students’ physical health test has entered the track of benign development, experienced the reform in 1975, 2002, 2007, and the partial revision in 1982, 1990, 2014. With the continuous reform and revision of physical fi tness testing standards in the whole academic community, physical fi tness testing standards have become a research hotspot in recent years.This review will study the evolution of the history of physical fi tness testing system for Chinese students, infl uencing factors and existing problems

Heavy metal induced ecophysiological function alterations in the euhalophyte Suaeda salsa

Heavy metal accumulation affects the physiological status of plants. Suaeda salsa L. is used to investigate the toxic effects of cadmium (Cd) and lead (Pb) either alone or mixtures under the static test conditions. Cd-Pb mixture exposure can decrease lignin content and weaken the increase. Mitochondrial calcium content significantly reduced at 30 µM Cd and Pb exposure. Cd-Pb mixture exposure can increase calcium content under the same concentration exposure. Soluble sugar levels noted a significant decrease in Cd, Pb and Cd-Pb mixture exposure. The accumulations of Cd, Pb in S. salsa were significantly increased with exposure time. Soluble protein (SP) in S. salsa at 30 µM concentration treatments decreased with exposure time. Heat shock protein 70 (HSP70) was enhanced lightly along with the increase of added Cd-Pb from 30 to 70 &3181;M and then decreased below the controls which present a synergistic effect. Heat shock protein 60 (HSP60) increased slightly with the increase of Cd-Pb from 30 to 110 µM, and then decreased hereafter and significantly inhibited at 150 ƒÊM (p<0.05). Moreover, Cd-Pb mixture exposure significantly increased the Rubisco activity under lower concentration and presented antagonistic effect. At the same time, the viability percent decreased as increase Cd-Pb concentration exposure (p0.05), it presents a dose-dependent manner. Mitochondrial cells treated with Cd-Pb exposure obviously reduced the reactive oxygen species (ROS) levels in mitochondrial cells.Key words: Suaeda salsa, heavy metal, ecophysiological function

Toxicological responses in alfalfa (Medicago sativa) under joint stress of cadmium and napropamide

Joint effects of Cd2+ and napropamide in seeds, roots or leaves of alfalfa were investigated under different treatments. It was shown that single stress of Cd2+ or napropamide decreased chlorophyll content after 30 days of treatment in different concentrations. The decrease in chlorophyll content became insignificant under joint stress of Cd2+ and napropamide. It can be concluded that the interaction of Cd2+ and napropamide would aggravate the toxic effects on chlorophyll synthesis in leaves of alfalfa. The joint effect of Cd2+ and napropamide was markedly significant (p < 0.05) on the change of SP content in leaves in all treatment. Moreover, Cd2+ and napropamide mixture exposure can increase lignin content and present synergistic effect. In a mixture treated with Cd2+ and napropamide, 52% decrease in β-carotene content contrasted with the control in young leaves. The contents of protein thiols and non-protein thiols in the roots of alfalfa were significantly increased by Cd2+ treatment in all treatment levels. In contrast, increasing napropamide supply did not have any significant effect on the protein thiols and non-protein thiols content. The Cd2+ induced accumulation of O2•- in seeds could be increased by treatment with different Cd2+ concentration. Production of H2O2 and O2•- was also higher in the napropamide treatments than in the control. The addition of napropamide significantly increased the H2O2 and O2•- level in the seeds of alfalfa.Key words: Alfalfa, joint stress, cadmium, napropamide

Advances in fatty acid metabolism reprogramming of lung cancer

Lung cancer is the most common malignant tumor and the leading cause of cancer-related mortality. Although the development of targeted therapy and immunotherapy has significantly improved the efficacy and prognosis of lung cancer patients, the overall 5-year survival rate is still lower than 20%. Therefore, in-depth exploration of the pathogenesis of lung cancer has important clinical significance for the development of new diagnosis and treatment strategies and further improvement of patient survival. Metabolic reprogramming is a crucial way for tumors to maintain malignant biological behavior. Previous studies have shown that fatty acid metabolism reprogramming has profound effects on tumorigenesis and progression of lung cancer, suggesting that targeting lung cancer fatty acid metabolism might be an important direction for the development of new anti-tumor regimens. This paper, focusing on the reprogramming of fatty acid metabolism, reviewed the relationship between fatty acid metabolism and lung cancer progression from the aspects of the key protein molecules involved in each procedure of fatty acid metabolism (including uptake, synthesis, storage and decomposition), and discussed the application status and challenges of anti-tumor therapy targeting fatty acid metabolism, expecting to provide clues and insights for the development of novel treatment regimen for lung cancer

Clay mineralogy indicates a mildly warm and humid living environment for the Miocene hominoid from the Zhaotong Basin, Yunnan, China

Global and regional environmental changes have influenced the evolutionary processes of hominoid primates, particularly during the Miocene. Recently, a new Lufengpithecus cf. lufengensis hominoid fossil with a late Miocene age of ~6.2 Ma was discovered in the Shuitangba (STB) section of the Zhaotong Basin in Yunnan on the southeast margin of the Tibetan Plateau. To understand the relationship between paleoclimate and hominoid evolution, we have studied sedimentary, clay mineralogy and geochemical proxies for the late Miocene STB section (~16 m thick; ca. 6.7–6.0 Ma). Our results show that Lufengpithecus cf. lufengensis lived in a mildly warm and humid climate in a lacustrine or swamp environment. Comparing mid to late Miocene records from hominoid sites in Yunnan, Siwalik in Pakistan, and tropical Africa we find that ecological shifts from forest to grassland in Siwalik are much later than in tropical Africa, consistent with the disappearance of hominoid fossils. However, no significant vegetation changes are found in Yunnan during the late Miocene, which we suggest is the result of uplift of the Tibetan plateau combined with the Asian monsoon geographically and climatically isolating these regions. The resultant warm and humid conditions in southeastern China offered an important refuge for Miocene hominoids

Insights into innate immune cell evasion by Chlamydia trachomatis

Chlamydia trachomatis, is a kind of obligate intracellular pathogen. The removal of C. trachomatis relies primarily on specific cellular immunity. It is currently considered that CD4+ Th1 cytokine responses are the major protective immunity against C. trachomatis infection and reinfection rather than CD8+ T cells. The non-specific immunity (innate immunity) also plays an important role in the infection process. To survive inside the cells, the first process that C. trachomatis faces is the innate immune response. As the “sentry” of the body, mast cells attempt to engulf and remove C. trachomatis. Dendritic cells present antigen of C. trachomatis to the “commanders” (T cells) through MHC-I and MHC-II. IFN-γ produced by activated T cells and natural killer cells (NK) further activates macrophages. They form the body’s “combat troops” and produce immunity against C. trachomatis in the tissues and blood. In addition, the role of eosinophils, basophils, innate lymphoid cells (ILCs), natural killer T (NKT) cells, γδT cells and B-1 cells should not be underestimated in the infection of C. trachomatis. The protective role of innate immunity is insufficient, and sexually transmitted diseases (STDs) caused by C. trachomatis infections tend to be insidious and recalcitrant. As a consequence, C. trachomatis has developed a unique evasion mechanism that triggers inflammatory immunopathology and acts as a bridge to protective to pathological adaptive immunity. This review focuses on the recent advances in how C. trachomatis evades various innate immune cells, which contributes to vaccine development and our understanding of the pathophysiologic consequences of C. trachomatis infection

Case Report: Replacement of PD-1 inhibitors with PD-L1 inhibitors in the treatment of squamous non-small-cell lung carcinoma

BackgroundImmune checkpoint inhibitor (ICI)-associated cardiotoxicity is a relatively uncommon immune-related adverse effects (irAEs) with a high mortality rate. There are few recommendations for the replacement of different immune checkpoint inhibitors in domestic and international reports.Case presentationWe report a case of a patient with squamous non-small cell lung carcinoma (squamous NSCLC) who developed cardiotoxicity after being treated with a programmed death-1 (PD-1) inhibitor and then changed to a PD-L1 inhibitor to continue the treatment. A significant benefit was observed after four cycles of immunotherapy, and no further cardiotoxicity occurred after the treatment was started.ConclusionThis case demonstrates that myocardial damage induced by tislelizumab (PD-1 inhibitor) can be improved after switching to sugemalimab (PD-L1 inhibitor) and that antitumor immunotherapy is effective. This result may have important implications for optimizing immunotherapy management regimens in cancer patients