Gas-Solids Hydrodynamics in a CFB with 6 Cyclones and a Pang Leg

Solids volume fraction and particle velocity profiles were measured with a fiber optical probe in a cold circulating fluidized bed test rig with 6 parallel cyclones and a pant leg. Results in the pant leg zone, main bed zone and exit zone of the furnace are reported. The work also includes the influences of superficial gas velocity, secondary air rate and static bed height on the gas-solids hydrodynamics

Dissipation Dynamics and Dietary Risk Assessment of Four Fungicides as Preservatives in Pear

Fungicides, including thiophanate-methyl, tebuconazole, pyraclostrobin, and difenoconazole, have been widely used as preservatives to control fungal diseases during pear storage. However, the metabolic capability of pear for exogenous compounds decreases at lower storage temperatures, leading to an increase in the risk of exposure to chemical preservatives. In this work, a sensitive and stable ultraperformance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) analytical method was established to investigate the dissipation dynamics and dietary intake risk of four chemical preservatives in pears under different conditions. The mean recoveries of the preservatives in pear samples ranged from 73.2% to 117.1%, with relative standard deviations of 0.5–7.2%. The dissipation half-lives (T1/2) of thiophanate-methyl, tebuconazole, pyraclostrobin, and difenoconazole in pears were 7.2–21.1 d and 31.6–173.3 d at storage temperatures of 25 °C and 4 °C, respectively. The results of dietary risk evaluation showed that the intake risk of preservatives in commercial pears was acceptable. However, some pears from commercial supermarkets still contained preservatives at amounts that exceeded the maximum residue limit (MRL) set by the Chinese government. This work provides a guideline for the risk evaluation of fruit preservatives on human health

Dissipation Dynamics and Dietary Risk Assessment of Four Fungicides as Preservatives in Pear

Fungicides, including thiophanate-methyl, tebuconazole, pyraclostrobin, and difenoconazole, have been widely used as preservatives to control fungal diseases during pear storage. However, the metabolic capability of pear for exogenous compounds decreases at lower storage temperatures, leading to an increase in the risk of exposure to chemical preservatives. In this work, a sensitive and stable ultraperformance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) analytical method was established to investigate the dissipation dynamics and dietary intake risk of four chemical preservatives in pears under different conditions. The mean recoveries of the preservatives in pear samples ranged from 73.2% to 117.1%, with relative standard deviations of 0.5–7.2%. The dissipation half-lives (T1/2) of thiophanate-methyl, tebuconazole, pyraclostrobin, and difenoconazole in pears were 7.2–21.1 d and 31.6–173.3 d at storage temperatures of 25 °C and 4 °C, respectively. The results of dietary risk evaluation showed that the intake risk of preservatives in commercial pears was acceptable. However, some pears from commercial supermarkets still contained preservatives at amounts that exceeded the maximum residue limit (MRL) set by the Chinese government. This work provides a guideline for the risk evaluation of fruit preservatives on human health

Research on a Simulation Model of a Skywave Over-the-Horizon Radar Sea Echo Spectrum

The capability of a skywave over-the-horizon radar (SWR) to achieve the continuous observation of a wide range of ocean dynamics parameters via a single ionospheric reflection has been demonstrated by many scholars. In order to expand the method of SWR detection of ocean dynamics parameters, a simulation model of an SWR sea echo spectrum based on the Barrick sea surface scattering cross-section model (Barrick model) and 3D ray-tracing method, suitable for a narrow-beam, frequency-modulated continuous-wave radar system (FMCW), was established. Based on this model, we simulated ideal and contaminated SWR sea echo spectra, respectively with the 3D electron density data output by the International Reference Ionosphere (IRI) model. Then, we further analyzed the effects of the grazing incidence angle, scattering angle, scattering azimuth angle and fetch length on the sea surface scattering cross-sections, the retrieval precision of the sea surface wind direction, and the root-mean-square (RMS) wave height, using the simulation data calculated by the Barrick model. The results show that these angles and fetch length cause a small expansion and contraction of the scattering cross-section, and have no influence on the retrieval precision of the sea surface wind direction, but will affect the retrieval precision of the RMS wave height; the influence of the grazing incidence angle and scattering angle is ~2.5 times that of the scattering azimuth angle. The ideal SWR sea echo spectrum has small broadening, but the ionosphere phase contamination will cause serious broadening and shifting of the SWR sea echo spectrum, and the higher order nonlinear term has greater contamination

Table_2_PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis in gastric cancer.xlsx

Gastric cancer (GC) is a major health burden worldwide, but our understanding of GC is limited, and the prognosis is poor. Novel therapeutic strategies and biomarkers are urgently needed to improve GC patient outcomes. Previously, we identified PFDN2 as a novel key gene in gastric cancer based on its differential expression between cancer and normal tissues. However, the role and underlying mechanisms of PFDN2 in GC remain elusive. In this article, we demonstrated that PFDN2 is highly expressed in GC and that upregulation of PFDN2 is associated with the progression of GC. We further found that PFDN2 could promote cell cycle progression by promoting MYBL2 expression. Mechanistically, we demonstrated that PFDN2 could upregulate MYBL2 expression by facilitating the nuclear translocation of hnRNPD, and thus promoting MYBL2 transcriptional program. In conclusion, we found that PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis and may serve as a potential biomarker and therapeutic target for GC.</p

Table_1_PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis in gastric cancer.xlsx

Gastric cancer (GC) is a major health burden worldwide, but our understanding of GC is limited, and the prognosis is poor. Novel therapeutic strategies and biomarkers are urgently needed to improve GC patient outcomes. Previously, we identified PFDN2 as a novel key gene in gastric cancer based on its differential expression between cancer and normal tissues. However, the role and underlying mechanisms of PFDN2 in GC remain elusive. In this article, we demonstrated that PFDN2 is highly expressed in GC and that upregulation of PFDN2 is associated with the progression of GC. We further found that PFDN2 could promote cell cycle progression by promoting MYBL2 expression. Mechanistically, we demonstrated that PFDN2 could upregulate MYBL2 expression by facilitating the nuclear translocation of hnRNPD, and thus promoting MYBL2 transcriptional program. In conclusion, we found that PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis and may serve as a potential biomarker and therapeutic target for GC.</p