The effects of topical triptolide in an animal model of contact dermatitis

published_or_final_versio

Increased apoptotic blood neutrophils and macrophages and decreased clearance of apoptotic neutrophils in systemic lupus erythematosus

published_or_final_versio

Health warning: might contain multiple personalities - the problem of homonyms in Thomson Reuters Essential Science Indicators

Author name ambiguity is a crucial problem in any type of bibliometric analysis. It arises when several authors share the same name, but also when one author expresses their name in different ways. This article focuses on the former, also called the “namesake” problem. In particular, we assess the extent to which this compromises the Thomson Reuters Essential Science Indicators (ESI) ranking of the top 1% most cited authors worldwide. We show that three demographic characteristics that should be unrelated to research productivity – name origin, uniqueness of one’s family name, and the number of initials used in publishing – in fact have a very strong influence on it. In contrast to what could be expected from Web of Science publication data, researchers with Asian names – and in particular Chinese and Korean names – appear to be far more productive than researchers with Western names. Furthermore, for any country, academics with common names and fewer initials also appear to be more productive than their more uniquely named counterparts. However, this appearance of high productivity is caused purely by the fact that these “academic superstars” are in fact composites of many individual academics with the same name. We thus argue that it is high time that Thomson Reuters starts taking name disambiguation in general, and non-Anglophone names in particular, more seriously

Flavonoid intake and the risk of age-related cataract in China’s Heilongjiang Province

Background/Objectives: Epidemiological evidence suggests that diets rich in flavonoids may reduce the risk of developing age-related cataract (ARC). Flavonoids are widely distributed in foods of plant origin and the objective of this study was to evaluate retrospectively the association between the intakes of the five flavonoid subclasses and the risk of ARC.  Subjects/Methods: A population-based case-control study (249 cases and 66 controls) was carried out in Heilongjiang province, which is located in the Northeast of China, and where intakes and availability of fresh vegetables and fruits can be limited. Dietary data gathered by food-frequency questionnaire (FFQ) were used to calculate flavonoid intake. Adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated by logistic regression.  Results: No linear associations between risk of developing ARC and intakes of total dietary flavonoids, anthocyanidins, flavon-3-ol, flavanone, total flavones or total flavonols were found, but quercetin and isorhamnetin intake was inversely associated with ARC risk (OR 11.78, 95% CI: 1.62-85.84, P<0.05, and OR 6.99, 95% CI:1.12-43.44, P<0.05, quartile 4 vs quartile 1, respectively).  Conclusion: As quercetin is contained in many plant foods and isorhamnetin is only contained in very few foods, we concluded that higher quercetin intake may be an important dietary factor in the reduction of risk of age-related cataract

Growth of Continuous Monolayer Graphene with Millimeter-sized Domains Using Industrially Safe Conditions.

We demonstrate the growth of continuous monolayer graphene films with millimeter-sized domains on Cu foils under intrinsically safe, atmospheric pressure growth conditions, suitable for application in roll-to-roll reactors. Previous attempts to grow large domains in graphene have been limited to isolated graphene single crystals rather than as part of an industrially useable continuous film. With both appropriate pre-treatment of the Cu and optimization of the CH4 supply, we show that it is possible to grow continuous films of monolayer graphene with millimeter scale domains within 80 min by chemical vapour deposition. The films are grown under industrially safe conditions, i.e., the flammable gases (H2 and CH4) are diluted to well below their lower explosive limit. The high quality, spatial uniformity, and low density of domain boundaries are demonstrated by charge carrier mobility measurements, scanning electron microscope, electron diffraction study, and Raman mapping. The hole mobility reaches as high as ~5,7002 m(2) V(-1) s(-1) in ambient conditions. The growth process of such high-quality graphene with a low H2 concentration and short growth times widens the possibility of industrial mass production

Effects of triptolide, an active ingredient of trypterygium Wilfordii Hook F (Thunder God Vine, a traditional Chinese herb), on rheumatoid synovial fibroblast function

published_or_final_versio