A lesson from the past and some hope for the future : the history academy and the schools, 1880-2007

Published in The history teacher, volume 41, number 2, pages 151-162Ye

The closing gates of democracy : frontier anxiety before the official end of the frontier

Published in American studies, volume 32, number 1, pages 49-66

The view from Philadelphia

Essay on the Atlas of the New West, published in Pacific historical review, volume 67, number 3, pages 382-39

Global West, American frontier

Published in Pacific historical review, volume 78, number 1, pages 1-26From article, "The author is a member of the history department at the University of Nevada, Las Vegas. This was his presidential address at the annual meeting of the Pacific Coast Branch, American Historical Association, in Pasadena, California, August 9, 2008. This article questions the common assumption that nineteenth-century audiences in America and around the world viewed the American western frontier as an exceptional place, like no other place on earth. Through examination of travel writings by Americans and Europeans who placed the West into a broader global context of developing regions and conquered colonies, we see that nineteenth-century audiences were commonly presented with a globally contextualized West. The article also seeks to broaden the emphasis in post-colonial scholarship on travel writers as agents of empire who commodified, exoticized, and objectified the colonized peoples and places they visited, by suggesting that travel writers were also often among the most virulent critics of empire and its consequences for the colonized.

Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation.

Autophagy is a conserved intracellular degradation pathway essential for protein homeostasis, survival and development. Defects in autophagic pathways have been connected to a variety of human diseases, including cancer and neurodegeneration. In the process of macroautophagy, cytoplasmic cargo is enclosed in a double-membrane structure and fused to the lysosome to allow for digestion and recycling of material. Autophagosome formation is primed by the ULK complex, which enables the downstream production of PI(3)P, a key lipid signalling molecule, on the phagophore membrane. The PI(3)P is generated by the PI3 kinase (PI3K) complex, consisting of the core components VPS34, VPS15 and Beclin 1. Beclin 1 is a central player in autophagy and constitutes a molecular platform for the regulation of autophagosome formation and maturation. Post-translational modifications of Beclin 1 affect its stability, interactions and ability to regulate PI3K activity, providing the cell with a plethora of strategies to fine-tune the levels of autophagy. Being such an important regulator, Beclin 1 is a potential target for therapeutic intervention and interfering with the post-translational regulation of Beclin 1 could be one way of manipulating the levels of autophagy. In this review, we provide an overview of the known post-translational modifications of Beclin 1 that govern its role in autophagy and how these modifications are maintained by input from several upstream signalling pathways. ▓

Movement and adjustment in twentieth-century Western writing

Published in Pacific historical review, volume 72, number 3, pages 393-404Western American literature in the twentieth century has effectively mirrored life in the region. The West has for centuries seen more geographic movement, and accompanying cultural adjustment, than other American regions. These themes of movement and adjustment have dominated western writing. Literary historians’ frameworks for categorizing and analyzing this writing have emphasized a tidy process of organic development in western writing, from “frontier fiction” to more mature “regional writing,” or from frontier to regional to post- regional literature. Such models underestimate the degree to which movement and adjustment continued to shape western writing in the twentieth century and tend to separate literature produced by white Europeans from that of other cultural groups. This essay suggests that the more fluid movement and adjustment model can better illuminate the connections between ostensibly separate cultural literary streams

Arabidopsis At5g39790 encodes a chloroplast-localized, carbohydrate-binding, coiled-coil domain-containing putative scaffold protein

<p>Abstract</p> <p>Background</p> <p>Starch accumulation and degradation in chloroplasts is accomplished by a suite of over 30 enzymes. Recent work has emphasized the importance of multi-protein complexes amongst the metabolic enzymes, and the action of associated non-enzymatic regulatory proteins. Arabidopsis At5g39790 encodes a protein of unknown function whose sequence was previously demonstrated to contain a putative carbohydrate-binding domain.</p> <p>Results</p> <p>We here show that At5g39790 is chloroplast-localized, and binds starch, with a preference for amylose. The protein persists in starch binding under conditions of pH, redox and Mg⁺²concentrations characteristic of both the day and night chloroplast cycles. Bioinformatic analysis demonstrates a diurnal pattern of gene expression, with an accumulation of transcript during the light cycle and decline during the dark cycle. A corresponding diurnal pattern of change in protein levels in leaves is also observed. Sequence analysis shows that At5g39790 has a strongly-predicted coiled-coil domain. Similar analysis of the set of starch metabolic enzymes shows that several have strong to moderate coiled-coil potential. Gene expression analysis shows strongly correlated patterns of co-expression between At5g39790 and several starch metabolic enzymes.</p> <p>Conclusion</p> <p>We propose that At5g39790 is a regulatory scaffold protein, persistently binding the starch granule, where it is positioned to interact by its coiled-coil domain with several potential starch metabolic enzyme binding-partners.</p