Lifetime Adherence to Physical Activity Recommendations and Fall Occurrence in Community-dwelling Older Adults: a Retrospective Cohort Study

Falling is a major health concern for community-dwelling older adults. Regular physical activity has been proposed to prevent falls. The aim of this study was to assess whether the achievement of the 2004 UK Department of Health physical activity recommendations over a lifetime had a protective effect against falling in older people. 313 community-dwelling older adults completed a questionnaire about lifetime physical activity and fall occurrence. There were significantly fewer falls in those who had led an active lifestyle compared to those who had not (χ2Yates=4.568, p=0.033), with a lower relative risk of fall occurrence for the active respondents (RR=0.671) compared to the inactive (RR=1.210). Of those who were sufficiently active in their early adulthood, the decade where there was the biggest decrease in remaining active enough was in the 60s. It is concluded that an active lifestyle may have decreased the likelihood of having a fall in older ag

c-Myc induced changes in higher order rDNA structure accompany growth factor stimulation of quiescent cells

Human c-Myc is believed to be a high level coordinator of protein synthesis capacity and cell growth rate, capable of activating transcription by all three nuclear RNA Polymerases. Direct activation of rDNA transcription by c-Myc is functionally conserved in rat cells, despite high divergence in non-coding rDNA sequences, suggesting that this coordinating role is likely to be a general within mammals. Upon re-feeding of starved cells, c-Myc activity enhances the efficiency of RNA Polymerase I and SL1/TIF-1B recruitment to the rDNA and rapidly induces higher order gene loop structures in rDNA chromatin that juxtapose upstream and downstream rDNA sequences. Furthermore c-Myc induced gene-loop formation in rDNA genes occurs independently of rDNA transcription, implying that it may be an early step in the re-programming of quiescent cells as they enter the growth cycle

Evaluating Context-Aware Applications Accessed Through Wearable Devices as Assistive Technology for Students with Disabilities

The purpose of these two single subject design studies was to evaluate the use of the wearable and context-aware technologies for college students with intellectual disability and autism as tools to increase independence and vocational skills. There is a compelling need for the development of tools and strategies that will facilitate independence, self-sufficiency, and address poor outcomes in adulthood for students with disabilities. Technology is considered to be a great equalizer for people with disabilities. The proliferation of new technologies allows access to real-time, contextually-based information as a means to compensate for limitations in cognitive functioning and decrease the complexity of prerequisite skills for successful use of previous technologies. Six students participated in two single-subject design studies; three students participate in Study I and three different students participated in Study II. The results of these studies are discussed in the context applying new technology applications to assist and improve individuals with intellectual disability and autism to self-manage technological supports to learn new skills, set reminders, and enhance independence. During Study I, students were successfully taught to use a wearable smartglasses device, which delivered digital auditory and visual information to complete three novel vocational tasks. The results indicated that all students learned all vocational task using the wearable device. Students also continued to use the device beyond the initial training phase to self-direct their learning and self-manage prompts for task completion as needed. During Study II, students were successfully taught to use a wearable smartwatch device to enter novel appointments for the coming week, as well as complete the tasks associated with each appointment. The results indicated that all students were able to self-operate the wearable device to enter appointments, attend all appointments on-time and complete all associated tasks