Mass analysis addition to the Differential Ion Flux Probe (DIFP) study

The objective of this study is to develop a technique to measure the characteristics of space plasmas under highly disturbed conditions; e.g., non-Maxwellian plasmas with strong drifting populations and plasmas contaminated by spacecraft outgassing. The approach, conducted in conjunction with current MSFC activities, is to extend the capabilities of the Differential Ion Flux Probe (DIFP) to include a high throughput mass measurement that does not require either high voltage or contamination sensitive devices such as channeltron electron multipliers or microchannel plates. This will significantly reduce the complexity and expense of instrument fabrication, testing, and integration of flight hardware compared to classical mass analyzers. The feasibility of the enhanced DIFP has been verified by using breadboard test models in a controlled plasma environment. The ability to manipulate particles through the instrument regardless of incident angle, energy, or ionic component has been amply demonstrated. The energy analysis mode is differential and leads directly to a time-of-flight mass measurement. With the new design, the DIFP will separate multiple ion streams and analyze each stream independently for ion flux intensity, velocity (including direction of motion), mass, and temperature (or energy distribution). In particular, such an instrument will be invaluable on follow-on electrodynamic TSS missions and, possibly, for environmental monitoring on the space station

The emissions of broadband electrostatic noise in the near vicinity of the shuttle orbiter

Measurements of the Space Shuttle environment from the STS-3 and Spacelab 2 missions indicate the presence of oblique ion streams and broadband electrostatic noise. A two-dimensional theoretical model is applied to study a possible causal relationship between the ion streams and the broadband noise; especially in terms of the ion acoustic wave and ion-ion wave modes. This model predicts the generation of waves with frequencies ranging from the ion cyclotron frequency up to values greater than the ion plasma frequency, with the maximum growth rate occurring in the 10 kHz range. These results are consistent with the observational data from the STS-3 mission. The model also shows that these two wave modes can co-exist only when the wave vectors of the two wave modes are nearly perpendicular. The parametric dependence of the wave instabilities on the plasma parameters, e.g. Nb/Ne, Te/Ti and the inclination of the wave propagation vector, is also studied.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26531/1/0000070.pd

Intercomparison among plasma wake models for plasmaspheric and ionospheric conditions

Intercomparisons are made among the angular distributions of ions in the wake of a body moving through a space plasma as computed from three different expressions (models). Both subsonic and supersonic relative flows are considered in order to examine the wake current depletion ratios under conditions realistic for the topside ionosphere and plasmasphere. Results of these comparisons demonstrate the importance of including the thermal flux at low Mach numbers and of taking into account the angular acceptance of ion detectors in making theory-experiment comparisons. Gradients in the angular variations of the fluxes are found to be steeper near the wake-ambient interface than closer to the maximum rarefaction region of all models, although quantitatively there is considerable variation among the models. From examining the variations of the wake depletion ratio parametrically with Mach number and normalized potential over ranges characteristic of the plasmasphere and topside ionosphere, we find considerable variation with both parameters, with sensitivity to normalized potential increasing dramatically with Mach number. Overall, however, the Mach number variation appears to be the more significant over this range of parameters.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26496/1/0000032.pd

Plasma Physics

Contains research objectives and reports on three research projects.United States Atomic Energy Commission AT(30-1)-1842

Satellite particle collection during active states of the Tethered Satellite System (TSS)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76723/1/AIAA-1996-2298-205.pd

The Frequency of Active and Quiescent Galaxies with Companions: Implications for the Feeding of the Nucleus

We analyze the idea that nuclear activity, either AGN or star formation, can be triggered by interactions, studying the percentage of active, HII and quiescent galaxies with companions. Our sample was selected from the Palomar survey, and avoids selection biases faced by previous studies. The comparison between the local galaxy density distributions showed that in most cases there is no statistically significant difference among galaxies of different activity types. The comparison of the percentage of galaxies with nearby companions showed that there is a higher percentage of LINERs, transition, and absorption line galaxies with companions than Seyferts and HII galaxies. However, we find that when we consider only galaxies of similar morphological types (ellipticals or spirals), there is no difference in the percentage of galaxies with companions among different activity types, indicating that the former result was due to the morphology-density effect. Also, only small differences are found when we consider galaxies with similar Halpha luminosities. The comparison between HII galaxies of different Halpha luminosities shows that there is a significantly higher percentage of galaxies with companions among the higher luminosity HII galaxies, indicating that interactions increase the amount of circumnuclear star formation, in agreement with previous results. The fact that we find that galaxies of different activity types have the same percentage of companions, suggests that interactions between galaxies is not a necessary condition to trigger the nuclear activity in AGNs. We compare our results with previous ones and discuss their implications. (abridged)Comment: 30 pages, including 6 figures and 3 tables. To appear in The Astronomical Journal, November issu

Diagnostic accuracy of the Abbott ID NOW SARS-CoV-2 rapid test for the triage of acute medical admissions

Background: Decisions to isolate patients at risk of having coronavirus disease 2019 (COVID-19) in the emergency department (ED) must be rapid and accurate to ensure prompt treatment and maintain patient flow whilst minimising nosocomial spread. Reverse transcription polymerase chain reaction (RT-PCR) assays are too slow to achieve this, and near-patient testing is being used increasingly to facilitate triage. The ID NOW severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) assay is an isothermal nucleic acid amplification near-patient test which targets the RNA-dependent RNA-polymerase gene. Aim: To assess the diagnostic performance of ID NOW as a COVID-19 triage tool for medical admissions from the ED of a large acute hospital. Methods: All adult acute medical admissions from the ED between 31st March and 31st July 2021 with valid ID NOW and RT-PCR results were included. The diagnostic accuracy of ID NOW [sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV)] was calculated against the laboratory reference standard. Discrepant results were explored further using cycle threshold values and clinical data. Findings: Two percent (124/6050) of medical admissions were SARS-CoV-2 positive on RT-PCR. Compared with PCR, ID NOW had sensitivity and specificity of 83.1% [95% confidence interval (CI) 75.4–88.7] and 99.5% (95% CI 99.3–99.6), respectively. PPV and NPV were 76.9% (95% CI 69.0–83.2) and 99.6% (95% CI 99.5–99.8), respectively. The median time from arrival in the ED to ID NOW result was 59 min. Conclusion: ID NOW provides a rapid and reliable adjunct for the safe triage of patients with COVID-19, and can work effectively when integrated into an ED triage algorithm

Evidence of Andreev bound states as a hallmark of the FFLO phase in κ\kappa-(BEDT-TTF)2_2Cu(NCS)2_2

Superconductivity is a quantum phenomena arising, in its simplest form, from pairing of fermions with opposite spin into a state with zero net momentum. Whether superconductivity can occur in fermionic systems with unequal number of two species distinguished by spin, atomic hyperfine states, flavor, presents an important open question in condensed matter, cold atoms, and quantum chromodynamics, physics. In the former case the imbalance between spin-up and spin-down electrons forming the Cooper pairs is indyced by the magnetic field. Nearly fifty years ago Fulde, Ferrell, Larkin and Ovchinnikov (FFLO) proposed that such imbalanced system can lead to exotic superconductivity in which pairs acquire finite momentum. The finite pair momentum leads to spatially inhomogeneous state consisting of of a periodic alternation of "normal" and "superconducting" regions. Here, we report nuclear magnetic resonance (NMR) measurements providing microscopic evidence for the existence of this new superconducting state through the observation of spin-polarized quasiparticles forming so-called Andreev bound states.Comment: 6 pages, 5 fig

An evaluation of seasonal variations in footwear worn by adults with inflammatory arthritis: a cross-sectional observational study using a web-based survey

Background: Foot problems are common in adults with inflammatory arthritis and therapeutic footwear can be effective in managing arthritic foot problems. Accessing appropriate footwear has been identified as a major barrier, resulting in poor adherence to treatment plans involving footwear. Indeed, previous New Zealand based studies found that many people with rheumatoid arthritis and gout wore inappropriate footwear. However, these studies were conducted in a single teaching hospital during the New Zealand summer therefore the findings may not be representative of footwear styles worn elsewhere in New Zealand, or reflect the potential influence of seasonal climate changes. The aim of the study was to evaluate seasonal variations in footwear habits of people with inflammatory arthritic conditions in New Zealand. Methods: A cross-sectional study design using a web-based survey. The survey questions were designed to elicit demographic and clinical information, features of importance when choosing footwear and seasonal footwear habits, including questions related to the provision of therapeutic footwear/orthoses and footwear experiences. Results: One-hundred and ninety-seven participants responded who were predominantly women of European descent, aged between 46–65 years old, from the North Island of New Zealand. The majority of participants identified with having either rheumatoid arthritis (35%) and/or osteoarthritis (57%) and 68% reported established disease (>5 years duration). 18% of participants had been issued with therapeutic footwear. Walking and athletic shoes were the most frequently reported footwear type worn regardless of the time of year. In the summer, 42% reported wearing sandals most often. Comfort, fit and support were reported most frequently as the footwear features of greatest importance. Many participants reported difficulties with footwear (63%), getting hot feet in the summer (63%) and the need for a sandal which could accommodate a supportive insole (73%). Conclusions: Athletic and walking shoes were the most popular style of footwear reported regardless of seasonal variation. During the summer season people with inflammatory arthritis may wear sandals more frequently in order to accommodate disease-related foot deformity. Healthcare professionals and researchers should consider seasonal variation when recommending appropriate footwear, or conducting footwear studies in people with inflammatory arthritis, to reduce non-adherence to prescribed footwear

In vivo clearance of surfactant lipids during acute pulmonary inflammation.

BACKGROUND: A decrease in pulmonary surfactant has been suggested to contribute to the lung dysfunction associated with pulmonary inflammation. A number of studies have implicated surfactant clearance as a possible mechanism for altered pool sizes. The objective of the current study was to specifically investigate the mechanisms of surfactant clearance in a rodent model of acute pulmonary inflammation. METHODS: Inflammation was induced by intrapulmonary instillation of lipopolysaccharide (LPS: 100 μg/kg). Lipid clearance was assessed at 18 and 72 hours post-LPS instillation by intratracheal administration of radiolabel surfactant-like liposomes 2 hours prior to isolation and analysis of inflammatory cells and type II cells. RESULTS: At both 18 and 72 hours after LPS instillation there was significantly less radioactivity recovered in the lavage fluid compared to respective control groups (p < 0.05). At both time points, the number of cells recovered by lavage and their associated radioactivity was greater compared to control groups (p < 0.01). There was no difference in recovery of radioactivity by isolated type II cells or other cells obtained from enzymatic digestion of lung tissue. CONCLUSION: These results show that increased clearance of surfactant lipids in our model of acute pulmonary inflammation is primarily due to the inflammatory cells recruited to the airspace and not increased uptake by alveolar type II cells