Interactive learning in biology with PhotoCD and associated software

This paper describes the pioneering development of flexible‐learning courseware in the teaching and learning of cell biology using a novel optical disk‐based technology — PhotoCD — and its associated computer software. The use of this format in an educational context for the manipulation of, and interaction with, photographic images in electronic form is presented for the first time. Examples of courseware which use PhotoCD, image‐enhancement and image‐management software in biology education are given, and an evaluation by undergraduates in biology education (student teachers) of these teaching and learning strategies is presente

REGIONAL AND SECTORAL EFFECTS OF COMPETITION FOR WHEAT TRANSPORTATION

Crop Production/Industries,

An Historical Review of Electroconvulsive Therapy

The initial clinical trial of electroconvulsive therapy (ECT) was performed by Ugo Cerletti and Lucino Bini at the University of Rome in 1938. The following paper will examine both the developments which led to the first trial of ECT, and the use of ECT over th e subsequent fifty years. Hopefully, by investigating the historical aspects of the development and progression of ECT, a better understanding of this treatment modality can be attained

Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1.

In the human sodium glucose cotransporter (hSGLT1) cycle, the protein undergoes conformational changes where the sugar-binding site alternatively faces the external and internal surfaces. Functional site-directed fluorometry was used to probe the conformational changes at the sugar-binding site. Residues (Y290, T287, H83, and N78) were mutated to cysteines. The mutants were expressed in Xenopus laevis oocytes and tagged with environmentally sensitive fluorescent rhodamines [e.g., tetramethylrhodamine (TMR)-thiols]. The fluorescence intensity was recorded as the mutants were driven into different conformations using voltage jumps. Sugar binding and transport by the fluorophore-tagged mutants were blocked, but Na+ binding and the voltage-dependent conformational transitions were unaffected. Structural models indicated that external Na+ binding opened a large aqueous vestibule (600 Å3) leading to the sugar-binding site. The fluorescence of TMR covalently linked to Y290C, T287C, and H83C decreased as the mutant proteins were driven from the inward to the outward open Na+-bound conformation. The time courses of fluorescence changes (milliseconds) were close to the SGLT1 capacitive charge movements. The quench in rhodamine fluorescence indicated that the environment of the chromophores became more polar with opening of the external gates as the protein transitioned from the inward to outward facing state. Structural analyses showed an increase in polar side chains and a decrease in hydrophobic side chains lining the vestibule, and this was reflected in solvation of the chromophore. The results demonstrate the opening and closing of external gates in real time, with the accompanying changes of polarity of the sugar vestibule

Health and Social Welfare Needs of the Elderly: A Preliminary Study

In a period of shrinking fiscal resources it is especially important that budgetary decision-making processes be based upon empirical data relating to the actual health and social service needs of the elderly. The present study consisted of a comprehensive survey of the social service needs of a random sample of 75 normative elderly citizens drawn from a multi-ethnic population. The results provide a preliminary data-base for administrative and policy-making bodies to allocate scarce social service resources. In an era of shrinking fiscal resources and drastic cuts in the provision of human services, funding decisions and budgetary allotments are often made on the basis of special interest group pressures, arbitrary preference or in response to the latest fad \u27need\u27 which has caught the public interest. Obviously it is vital that the available resources allocated to community mental health and other social service needs be distributed on a more equitable and rational basis

Performance-based research assessment is narrowing and impoverishing the university in New Zealand, UK and Denmark.

Susan Wright, Bruce Curtis, Lisa Lucas and Susan Robertson provide a basic outline of their working paper on how performance-based research assessment frameworks in different countries operate and govern academic life. They find that assessment methods steer academic effort away from wider purposes of the university, enhance the powers of leaders, propagate unsubstantiated myths of meritocracy, and demand conformity. But the latest quest for ‘impact’ may actually in effect unmask these operations and diversify ‘what counts’ across contexts